GB1467880A - Dialysis apparatus with selective chemical activity - Google Patents
Dialysis apparatus with selective chemical activityInfo
- Publication number
- GB1467880A GB1467880A GB2985174A GB2985174A GB1467880A GB 1467880 A GB1467880 A GB 1467880A GB 2985174 A GB2985174 A GB 2985174A GB 2985174 A GB2985174 A GB 2985174A GB 1467880 A GB1467880 A GB 1467880A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dialysate
- dialysis
- adsorbent
- dialysis membrane
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000502 dialysis Methods 0.000 title abstract 7
- 239000000126 substance Substances 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 239000012528 membrane Substances 0.000 abstract 5
- 239000003463 adsorbent Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000001143 conditioned effect Effects 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229910001928 zirconium oxide Inorganic materials 0.000 abstract 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 abstract 1
- LEHFSLREWWMLPU-UHFFFAOYSA-B zirconium(4+);tetraphosphate Chemical compound [Zr+4].[Zr+4].[Zr+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LEHFSLREWWMLPU-UHFFFAOYSA-B 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1692—Detection of blood traces in dialysate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/32—Controlling or regulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/10—Spiral-wound membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
- B01D67/00933—Chemical modification by addition of a layer chemically bonded to the membrane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/10—Supported membranes; Membrane supports
- B01D69/105—Support pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0496—Urine
- A61M2202/0498—Urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/22—Cooling or heating elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/90—Additional auxiliary systems integrated with the module or apparatus
- B01D2313/903—Integrated control or detection device
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Water Supply & Treatment (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
1467880 Dialysis apparatus V H HYDEN 5 July 1974 [5 July 1973] 29851/74 Heading B1X [Also in Division C3] Dialysis apparatus, such as an artificial kidney, with selective chemical activity, which includes a semipermeable dialysis membrane forming a partition between the liquid to be dialysed and a dialysate, the dialysis membrane being selected to permit the passage of substances with molecular weights of at least 2500, a first surface of the dialysis membrane facing the dialysed liquid, a second surface facing the dialysate, at least one of its surface being coated with at least one selectively chemically active substance insolubilised on the surface and at least one selectively acting adsorbent being provided in the circuit of the dialysate. The chemically active substance may be an enzyme or other protein, or an antibiotic. The dialysis membrane may be in the form of a flattened tube, with a spacing member having an open structure carrying an adsorbent and the membrane and spacing member wound helically together. The adsorbent may consist of pre-conditioned zirconium phosphate and/or zirconium oxide, optionally in combination with active carbon.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7309501A SE373752B (en) | 1973-07-05 | 1973-07-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1467880A true GB1467880A (en) | 1977-03-23 |
Family
ID=20317987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2985174A Expired GB1467880A (en) | 1973-07-05 | 1974-07-05 | Dialysis apparatus with selective chemical activity |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS5726801B2 (en) |
AT (1) | AT353943B (en) |
CA (1) | CA1067830A (en) |
CH (1) | CH597889A5 (en) |
DE (1) | DE2430171C2 (en) |
FR (1) | FR2235721B1 (en) |
GB (1) | GB1467880A (en) |
IT (1) | IT1015537B (en) |
NL (1) | NL167330C (en) |
SE (1) | SE373752B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002043859A3 (en) * | 2000-11-28 | 2003-01-16 | Renal Solutions Inc | Cartridges useful in cleaning dialysis solutions |
US6878283B2 (en) | 2001-11-28 | 2005-04-12 | Renal Solutions, Inc. | Filter cartridge assemblies and methods for filtering fluids |
US7033498B2 (en) | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2532883C2 (en) * | 1975-07-23 | 1983-03-24 | Hans-Peter Dr. 6906 Leimen Geisen | Method and device for the selective extraction of a reaction partner of an immune reaction from the flowing blood of living organisms |
JPS5340691A (en) * | 1976-04-01 | 1978-04-13 | Korufu Fuaundeeshiyon Za | Method and apparatus for removing impurities from fluids |
JPS54126679A (en) * | 1978-03-24 | 1979-10-02 | Kuraray Co Ltd | Membrane type fluid treating device |
ATE16456T1 (en) * | 1979-06-11 | 1985-11-15 | Gambro Lundia Ab | DEVICE FOR REMOVING SUBSTANCES FROM A LIQUID. |
DE3270740D1 (en) * | 1981-06-29 | 1986-05-28 | Clara Ambrus | Apparatus for removing heavy metal ions from blood |
US9713666B2 (en) | 2013-01-09 | 2017-07-25 | Medtronic, Inc. | Recirculating dialysate fluid circuit for blood measurement |
US9974896B2 (en) * | 2014-06-24 | 2018-05-22 | Medtronic, Inc. | Method of zirconium phosphate recharging |
US10159957B2 (en) | 2013-11-26 | 2018-12-25 | Medtronic, Inc. | Zirconium phosphate recharging customization |
US9884145B2 (en) | 2013-11-26 | 2018-02-06 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
US10064986B2 (en) | 2013-11-26 | 2018-09-04 | Medtronic, Inc. | Recharger for recharging zirconium phosphate and zirconium oxide modules |
US10537875B2 (en) | 2013-11-26 | 2020-01-21 | Medtronic, Inc. | Precision recharging of sorbent materials using patient and session data |
US10052612B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate recharging method and apparatus |
US10052624B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate and zirconium oxide recharging flow paths |
US10099214B2 (en) | 2013-11-26 | 2018-10-16 | Medtronic, Inc. | Zirconium phosphate and zirconium oxide recharger control logic and operational process algorithms |
US10099215B2 (en) | 2013-11-26 | 2018-10-16 | Medtronic, Inc. | Management of recharger effluent pH |
WO2015199768A1 (en) | 2014-06-24 | 2015-12-30 | Medtronic, Inc. | Stacked sorbent assembly |
WO2015199766A1 (en) | 2014-06-24 | 2015-12-30 | Medtronic, Inc. | Modular dialysate regeneration assembly |
US10981148B2 (en) | 2016-11-29 | 2021-04-20 | Medtronic, Inc. | Zirconium oxide module conditioning |
US11167070B2 (en) | 2017-01-30 | 2021-11-09 | Medtronic, Inc. | Ganged modular recharging system |
US10960381B2 (en) | 2017-06-15 | 2021-03-30 | Medtronic, Inc. | Zirconium phosphate disinfection recharging and conditioning |
US11213616B2 (en) | 2018-08-24 | 2022-01-04 | Medtronic, Inc. | Recharge solution for zirconium phosphate |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2720879A (en) * | 1950-08-01 | 1955-10-18 | Gasca Albin | Dialysis apparatus |
US2756206A (en) * | 1953-07-14 | 1956-07-24 | Gobel Charles | Dialyzer |
DE1064199B (en) * | 1956-05-04 | 1959-08-27 | Dr Bruno Watschinger | Artificial kidney |
US3441142A (en) * | 1966-07-21 | 1969-04-29 | Dow Chemical Co | Nonthrombogenic plastic membranes |
GB1189458A (en) * | 1967-09-27 | 1970-04-29 | Nat Res Dev | Improvements in or relating to dialysers |
US3669880A (en) * | 1969-06-30 | 1972-06-13 | Cci Aerospace Corp | Recirculation dialysate system for use with an artificial kidney machine |
BE759911A (en) * | 1969-12-05 | 1971-05-17 | Worthington Biochem Corp | ACTIVE ENZYMATIC PRODUCTS |
US3709367A (en) * | 1970-04-08 | 1973-01-09 | Baxter Laboratories Inc | Support structure for membrane diffusion devices |
US3843446A (en) * | 1971-04-20 | 1974-10-22 | Research Corp | Preparation of enzymatically active membranes |
-
1973
- 1973-07-05 SE SE7309501A patent/SE373752B/xx unknown
-
1974
- 1974-06-13 CH CH810574A patent/CH597889A5/xx not_active IP Right Cessation
- 1974-06-18 AT AT503074A patent/AT353943B/en not_active IP Right Cessation
- 1974-06-21 CA CA203,072A patent/CA1067830A/en not_active Expired
- 1974-06-24 DE DE2430171A patent/DE2430171C2/en not_active Expired
- 1974-06-28 IT IT24603/74A patent/IT1015537B/en active
- 1974-07-03 JP JP7547374A patent/JPS5726801B2/ja not_active Expired
- 1974-07-04 FR FR7423304A patent/FR2235721B1/fr not_active Expired
- 1974-07-05 GB GB2985174A patent/GB1467880A/en not_active Expired
-
1975
- 1975-01-02 NL NL7500007.A patent/NL167330C/en not_active IP Right Cessation
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002043859A3 (en) * | 2000-11-28 | 2003-01-16 | Renal Solutions Inc | Cartridges useful in cleaning dialysis solutions |
US6627164B1 (en) | 2000-11-28 | 2003-09-30 | Renal Solutions, Inc. | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
US6818196B2 (en) | 2000-11-28 | 2004-11-16 | Renal Solutions, Inc. | Zirconium phosphate and method of making the same |
US7033498B2 (en) | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
US7101519B2 (en) | 2000-11-28 | 2006-09-05 | Renal Solutions, Inc. | Zirconium basic carbonate and methods of making the same |
CN102602992A (en) * | 2000-11-28 | 2012-07-25 | 雷纳尔溶液公司 | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
CN102602992B (en) * | 2000-11-28 | 2015-04-08 | 雷纳尔溶液公司 | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
US6878283B2 (en) | 2001-11-28 | 2005-04-12 | Renal Solutions, Inc. | Filter cartridge assemblies and methods for filtering fluids |
Also Published As
Publication number | Publication date |
---|---|
JPS5726801B2 (en) | 1982-06-07 |
ATA503074A (en) | 1979-05-15 |
SE7309501L (en) | 1975-01-07 |
CH597889A5 (en) | 1978-04-14 |
SE373752B (en) | 1975-02-17 |
NL7500007A (en) | 1976-07-06 |
FR2235721A1 (en) | 1975-01-31 |
FR2235721B1 (en) | 1976-10-22 |
CA1067830A (en) | 1979-12-11 |
AT353943B (en) | 1979-12-10 |
JPS5070281A (en) | 1975-06-11 |
NL167330C (en) | 1981-12-16 |
NL167330B (en) | 1981-07-16 |
DE2430171C2 (en) | 1983-10-06 |
IT1015537B (en) | 1977-05-20 |
DE2430171A1 (en) | 1975-01-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |