GB1461345A - Method and device for determining the perfusion efficiency factor of animal tissue - Google Patents
Method and device for determining the perfusion efficiency factor of animal tissueInfo
- Publication number
- GB1461345A GB1461345A GB397474A GB397474A GB1461345A GB 1461345 A GB1461345 A GB 1461345A GB 397474 A GB397474 A GB 397474A GB 397474 A GB397474 A GB 397474A GB 1461345 A GB1461345 A GB 1461345A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tissue
- perfusion
- indicator
- temperature
- annulus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1491—Heated applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
Abstract
1461345 Perfusion efficiency factor (blood perfusion and blood concentration) L ESCHWEILER & CO 29 Jan 1974 03974/74 Heading G1N(E) In a device-for measuring the "perfusion efficiency factor" (p.e.f.) of a piece of animal tissue, the perfusion of the indicator is measured with the aid of one or more temperature sensors 11, 13. (The p.e.f. is a function of the rate of flow or perfusion I of an indicator - say blood with a radio-active tracer in it - flowing through the tissue, and a function of the concentration C of the indicator i.e. p.e.f. = F(I,C)). One sensor 11 is attached to a temperature controlled annulus 10 of good thermo-conductive material. In some cases Figs. 1, 2 and 4, Fig. 4 (not shown) a temperature sensor 13 is positioned centrally of the annulus so as to be in contact with the tissue. Thus by measuring the temperature difference between the annulus (which is maintained at a higher temperature than the body temperature of the tissue by a heating coil 12) and the temperature of the tissue at the centre of the annulus, a value of the perfusion of the indicator (blood) can be determined. A value can also be determined by measuring the amount of heat required to maintain the annulus 10 at a predetermined temperature above the body temperature. The indicator concentration can be measured with the aid of a radio-active detector 14, Fig. 1 (when a radio-active tracer is present). Alternatively the indicator cencentration may be measured polarographically, by a network of electrodes 23, 24, 25 and 26 imbedded in glass 22. The electrodes are in contact with an electrolyte which may be stored in a foil 28 surrounded by a gas-permeable membrane 27 to enable measurement of the local oxygen gas pressure given out by the tissue. The electrodes 23, 24 and 25 have small time constants and are located at the corners of an equilateral triangle Fig. 5 (not shown), the other electrode 26 which serves as a calibrating electrode and has a high time is located at the centre of the triangle. The electrical outputs of the two measuring instruments may thus be combined Fig. 6 (not shown) to provide a value of the perfusion efficiency factor. The entire measuring means is accomodated in a housing 15 provided with an annular groove 16 with support rings 17. The groove 16 is connected via a passage 16a with a nipple 18 to a vacuum pump to permit fitment of the measuring means to the tissue. The housing may also be provided with a flange 31 having adhesive members 31. The housing itself may be incorporated in an inflatable pressure exerting cuff D which can be placed around the human arm &c. Upon inflation the pressure exerted will locally interrupt the supply of blood so that the extent of skin breathing can be determined by the time derivative of the oxygen gas pressure.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB397474A GB1461345A (en) | 1974-01-29 | 1974-01-29 | Method and device for determining the perfusion efficiency factor of animal tissue |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB397474A GB1461345A (en) | 1974-01-29 | 1974-01-29 | Method and device for determining the perfusion efficiency factor of animal tissue |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1461345A true GB1461345A (en) | 1977-01-13 |
Family
ID=9768422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB397474A Expired GB1461345A (en) | 1974-01-29 | 1974-01-29 | Method and device for determining the perfusion efficiency factor of animal tissue |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1461345A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003055385A1 (en) * | 2001-12-21 | 2003-07-10 | Unisense A/S | Multifibre sensor for measuring perfusion |
WO2003092491A1 (en) * | 2002-05-06 | 2003-11-13 | Uscom Pty Ltd | Blood flow oxygen measurement system and method |
AU2003227122B2 (en) * | 2002-05-06 | 2008-05-01 | Uscom Limited | Blood flow oxygen measurement system and method |
WO2008132205A1 (en) | 2007-04-27 | 2008-11-06 | Sentec Ag | Device and method for transcutaneous determination of blood gases |
US7630766B2 (en) | 2002-07-03 | 2009-12-08 | Uscom Limited | Exercise responsive pacemaker tuning method using Doppler blood flow measurements to adjust pacing for optimized flow |
US7789835B2 (en) | 2003-01-22 | 2010-09-07 | Uscom Limited | Methods and systems for determining cardiac output based on a valve cross sectional area estimate |
WO2016151281A1 (en) * | 2015-03-25 | 2016-09-29 | Epitherm Limited | Improvements in or relating to measurement of blood pressure |
-
1974
- 1974-01-29 GB GB397474A patent/GB1461345A/en not_active Expired
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003055385A1 (en) * | 2001-12-21 | 2003-07-10 | Unisense A/S | Multifibre sensor for measuring perfusion |
WO2003092491A1 (en) * | 2002-05-06 | 2003-11-13 | Uscom Pty Ltd | Blood flow oxygen measurement system and method |
US7338447B2 (en) | 2002-05-06 | 2008-03-04 | Uscom Pty Ltd | Blood flow oxygen measurement system and method |
AU2003227122B2 (en) * | 2002-05-06 | 2008-05-01 | Uscom Limited | Blood flow oxygen measurement system and method |
US7630766B2 (en) | 2002-07-03 | 2009-12-08 | Uscom Limited | Exercise responsive pacemaker tuning method using Doppler blood flow measurements to adjust pacing for optimized flow |
US7789835B2 (en) | 2003-01-22 | 2010-09-07 | Uscom Limited | Methods and systems for determining cardiac output based on a valve cross sectional area estimate |
WO2008132205A1 (en) | 2007-04-27 | 2008-11-06 | Sentec Ag | Device and method for transcutaneous determination of blood gases |
US8527023B2 (en) | 2007-04-27 | 2013-09-03 | Sentec Ag | Device and method for transcutaneous determination of blood gases |
WO2016151281A1 (en) * | 2015-03-25 | 2016-09-29 | Epitherm Limited | Improvements in or relating to measurement of blood pressure |
US10470672B2 (en) | 2015-03-25 | 2019-11-12 | Epitherm Limited | Measurement of blood pressure |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
414F | Notice of opposition given (sect. 14/1949) | ||
414A | Case decided by the comptroller ** specification amended (sect. 14/1949) | ||
PS | Patent sealed | ||
SP | Amendment (slips) printed | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |