GB1460028A - Process for producing 3,5-cyclic adenylic acid - Google Patents
Process for producing 3,5-cyclic adenylic acidInfo
- Publication number
- GB1460028A GB1460028A GB4851573A GB4851573A GB1460028A GB 1460028 A GB1460028 A GB 1460028A GB 4851573 A GB4851573 A GB 4851573A GB 4851573 A GB4851573 A GB 4851573A GB 1460028 A GB1460028 A GB 1460028A
- Authority
- GB
- United Kingdom
- Prior art keywords
- camp
- fluoride
- precursor
- producing
- nutrient medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1460028 Producing 3<SP>1</SP>,5<SP>1</SP>-cyclic adenylic acid by fermentation KIKKOMAN SHOYU CO Ltd 15 Oct 1973 [16 Oct 1972 23 Feb 1973] 48515/73 Heading C2P 3<SP>1</SP>,5<SP>1</SP>-Cyclic adenylic acid (CAMP) is obtained by culturing under aerobic conditions a mutant strain of a microorganism in a nutrient medium containing a source of carbon, a source of nitrogen and one or more inorganic salts, and recovering the 3<SP>1</SP>,5<SP>1</SP>-cyclic adenylic acid accumulated in the nutrient medium, the mutant strain being one obtainable by subjecting a microorganism capable of producing CAMP in the presence of a precursor and/or of a fluoride to mutation treatment and being one which is capable of producing CAMP in substantial amount in the absence of a precursor, a fluoride or a fluoride and a precursor. Specified parent strains from which suitable mutants can be obtained are Corynebacterium murisepticum No. 7 (ATCC 21374), Arthrobacter 11 (ATCC 21375) and Microbacterium No. 205 (ATCC 21376). The mutant strains may be obtained from the parent strain by conventional artificial mutation treatment, e.g. by subjecting the parent strain to X-radiation, irradiation with U.V. light or to treatment with a chemical mutagenic agent, e.g. nitrosoguanidine, diethyl sulphate, methylethyl sulphate, NaNO 2 , acridine or nitrogen mustard. The nutrient medium may contain a precursor and/or fluoride or may be free of both a precursor and fluoride. Several precursors which may be added to the nutrient medium are specified and the medium may also contain one or more cyclic 3,5<SP>1</SP>-nucleotide phosphodiesterase inhibitors several of which are specified. The culturing is preferably carried out at a pH of from 5-9 and at 20‹ to 40‹ C. The CAMP can be isolated by treatment with active carbon or with a cationic or anionic exchange resin or by addition of a solvent in which CAMP is insoluble or by a combination of two or more such treatments. Examples are given for preparing suitable mutants and their use in the production of CAMP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10278072A JPS5237072B2 (en) | 1972-10-16 | 1972-10-16 | |
| JP2134273A JPS5414670B2 (en) | 1973-02-23 | 1973-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1460028A true GB1460028A (en) | 1976-12-31 |
Family
ID=26358375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4851573A Expired GB1460028A (en) | 1972-10-16 | 1973-10-15 | Process for producing 3,5-cyclic adenylic acid |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2351738C3 (en) |
| FR (1) | FR2202938B1 (en) |
| GB (1) | GB1460028A (en) |
-
1973
- 1973-10-15 FR FR7336781A patent/FR2202938B1/fr not_active Expired
- 1973-10-15 DE DE19732351738 patent/DE2351738C3/en not_active Expired
- 1973-10-15 GB GB4851573A patent/GB1460028A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2202938A1 (en) | 1974-05-10 |
| DE2351738A1 (en) | 1974-04-25 |
| DE2351738B2 (en) | 1978-06-29 |
| DE2351738C3 (en) | 1979-02-22 |
| FR2202938B1 (en) | 1978-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |