GB1456354A - Process for the preparation of carnitine hydrochloride - Google Patents
Process for the preparation of carnitine hydrochlorideInfo
- Publication number
- GB1456354A GB1456354A GB3704275A GB3704275A GB1456354A GB 1456354 A GB1456354 A GB 1456354A GB 3704275 A GB3704275 A GB 3704275A GB 3704275 A GB3704275 A GB 3704275A GB 1456354 A GB1456354 A GB 1456354A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carnitine hydrochloride
- reacting
- carnitine
- alkyl ester
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JXXCENBLGFBQJM-FYZOBXCZSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O JXXCENBLGFBQJM-FYZOBXCZSA-N 0.000 title 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000005907 alkyl ester group Chemical group 0.000 abstract 2
- 229960004203 carnitine Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- -1 trimethyl ammonium halide Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1456354 Carnitine hydrochloride LONZA Ltd 9 Sept 1975 [25 Sept 1974 (2)] 37042/75 Heading C2 Carnitine hydrochloride is made by (a) reacting an enolized gamma-haloacetic acid alkyl ester with trimethylamine to give a (3-carboalkoxy - 2 - oxopropyl) trimethyl ammonium halide, (b) hydrogenating the latter to a carnitine alkyl ester and (c) hydrolysing the ester with aqueous hydrochloric acid to give carnitine hydrochloride. In a modification the product of step (a) is obtained by reacting the gammahaloacetic acid alkyl ester with an alcoholate and then reacting the product with trimethylamine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1297174A CH596147A5 (en) | 1974-09-25 | 1974-09-25 | |
| CH1297074A CH588443A5 (en) | 1974-09-25 | 1974-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1456354A true GB1456354A (en) | 1976-11-24 |
Family
ID=25711305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3704275A Expired GB1456354A (en) | 1974-09-25 | 1975-09-09 | Process for the preparation of carnitine hydrochloride |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5163123A (en) |
| AR (1) | AR205840A1 (en) |
| AT (1) | AT349657B (en) |
| BR (1) | BR7506185A (en) |
| DD (1) | DD123735A5 (en) |
| GB (1) | GB1456354A (en) |
| IE (1) | IE41684B1 (en) |
| IL (1) | IL48135A (en) |
| LU (1) | LU73458A1 (en) |
| SE (2) | SE7510666L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH075528B2 (en) * | 1988-11-24 | 1995-01-25 | 高砂香料工業株式会社 | Method for producing carnitine hydrochloride |
-
1975
- 1975-01-01 AR AR260532A patent/AR205840A1/en active
- 1975-09-09 GB GB3704275A patent/GB1456354A/en not_active Expired
- 1975-09-10 IE IE1971/75A patent/IE41684B1/en unknown
- 1975-09-18 IL IL48135A patent/IL48135A/en unknown
- 1975-09-22 DD DD188474A patent/DD123735A5/xx unknown
- 1975-09-22 JP JP50115420A patent/JPS5163123A/en active Pending
- 1975-09-23 SE SE7510666A patent/SE7510666L/en unknown
- 1975-09-24 AT AT731975A patent/AT349657B/en not_active IP Right Cessation
- 1975-09-24 BR BR7506185*A patent/BR7506185A/en unknown
- 1975-09-25 LU LU73458A patent/LU73458A1/xx unknown
-
1978
- 1978-02-15 SE SE7801764A patent/SE7801764L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD123735A5 (en) | 1977-01-12 |
| SE7510666L (en) | 1976-03-26 |
| AR205840A1 (en) | 1976-06-07 |
| IE41684B1 (en) | 1980-02-27 |
| IL48135A0 (en) | 1975-11-25 |
| ATA731975A (en) | 1978-09-15 |
| IL48135A (en) | 1978-10-31 |
| LU73458A1 (en) | 1976-08-13 |
| BR7506185A (en) | 1976-08-03 |
| IE41684L (en) | 1976-03-25 |
| SE7801764L (en) | 1978-02-15 |
| JPS5163123A (en) | 1976-06-01 |
| AT349657B (en) | 1979-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |