GB1454109A - Medicament preparations - Google Patents

Medicament preparations

Info

Publication number
GB1454109A
GB1454109A GB5639473A GB5639473A GB1454109A GB 1454109 A GB1454109 A GB 1454109A GB 5639473 A GB5639473 A GB 5639473A GB 5639473 A GB5639473 A GB 5639473A GB 1454109 A GB1454109 A GB 1454109A
Authority
GB
United Kingdom
Prior art keywords
medicament
composition
glycol
dialkylated
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5639473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00313431A external-priority patent/US3833725A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of GB1454109A publication Critical patent/GB1454109A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1454109 Stabilised medicaments SYNTEX (USA) INC 5 Dec 1973 [8 Dec 1972 8 Nov 1973] 56394/73 Heading A5B Substantially anhydrous medicament compositions comprise a major amount (i.e. more than 50 % by weight of the composition, excluding the medicament) of a dialkylated mono- or polyalkylene glycol e.g. glyme, diglyme, triglyme, tetraglyme, dimethyl ether of triethylene glycol, polyethylene glycol 350, 550 and 750-dimethyl ethers, and a pharmaceutically effective amount of an active medicament or a pharmaceutically acceptable salt thereof, the composition being substantially devoid of peroxides and other oxidation products in quantities which interfere with the carrier or stabilizing properties of the composition, and containing up to 5% by weight of water, the dialkylated glycol serving to stabilize the chemical activity of the medicament. The composition may include at least one anti-oxidant for the dialkylated glycol e.g. propyl gallate, vitamin E, butylated hydroxyanisole, and/or butylated hydroxytoluene. The medicament may be an antibiotic such as tetracycline, oxytetracycline, chlorotetracycline, chloramphenicol, gramicidin, candicidin, and nystatin; an anaesthetic such as benzocaine and xylocaine: an analgesic such as aspirin and 2-(6-methoxy-2-naphthyl)propionic acid, antiinflammatory steroids such as 6α, 9α-difluoro- 11# - hydroxy - 16α, 17α-isopropylidenedioxypregna-1, 4-diene-3, 20-dione, 9α, 11#, 21-trichloro-6α-fluo-16α, 17α-isopropylidenedioxy-pregna-1, 4-diene-3, 20-dione; naturally occuring or synthetic prostaglandins such as PGE 2 and PGF 2 α; palmitic acid diethanolamide, oleic acid diethanolamide, antihistamines; antibaoterials and fungicides. The compositions may be in the form of creams, ointments, oral or vaginal tablets, rectal or vaginal suppositories, encapsulated preparations, bougies and food premixes.
GB5639473A 1972-12-08 1973-12-05 Medicament preparations Expired GB1454109A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US00313431A US3833725A (en) 1972-12-08 1972-12-08 Dialkylated glycol compositions and medicament preparations containing same
US41396573A 1973-11-08 1973-11-08

Publications (1)

Publication Number Publication Date
GB1454109A true GB1454109A (en) 1976-10-27

Family

ID=26978866

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5639473A Expired GB1454109A (en) 1972-12-08 1973-12-05 Medicament preparations

Country Status (6)

Country Link
JP (1) JPS5726244B2 (en)
CA (1) CA1043259A (en)
DE (1) DE2358644C3 (en)
ES (1) ES421299A1 (en)
FR (1) FR2209544B1 (en)
GB (1) GB1454109A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2563429C2 (en) * 2009-07-09 2015-09-20 Кордис Корпорейшн Rapamicin-releasing stent

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5391110A (en) * 1977-01-20 1978-08-10 Yamanouchi Pharmaceut Co Ltd Novel drug composition for rectal infusion
US4115563A (en) * 1977-03-14 1978-09-19 Sterling Drug Inc. Pharmaceutical steroid formulation
US4310543A (en) * 1980-10-09 1982-01-12 Hoffmann-La Roche Inc. Prostaglandin compositions
AU546872B2 (en) * 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
GB8718886D0 (en) * 1987-08-10 1987-09-16 Ici America Inc Composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1296515A (en) * 1958-12-05 1962-06-22 Boehringer & Soehne Gmbh Process for making solutions of chloramphenicol in aqueous liquids
US3308217A (en) * 1965-02-09 1967-03-07 Lowy Lawrence Method of granulating materials for subsequent forming into tablets

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2563429C2 (en) * 2009-07-09 2015-09-20 Кордис Корпорейшн Rapamicin-releasing stent
US9327060B2 (en) 2009-07-09 2016-05-03 CARDINAL HEALTH SWITZERLAND 515 GmbH Rapamycin reservoir eluting stent

Also Published As

Publication number Publication date
JPS5052220A (en) 1975-05-09
ES421299A1 (en) 1977-05-16
DE2358644A1 (en) 1974-07-04
JPS5726244B2 (en) 1982-06-03
FR2209544A1 (en) 1974-07-05
AU6319173A (en) 1975-06-05
DE2358644B2 (en) 1979-04-05
FR2209544B1 (en) 1978-03-24
CA1043259A (en) 1978-11-28
DE2358644C3 (en) 1979-11-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee