GB1452877A - 2-oxo-1,2,3,4-tetra-hydropyrido-2,3,d-pyrimidines - Google Patents

2-oxo-1,2,3,4-tetra-hydropyrido-2,3,d-pyrimidines

Info

Publication number
GB1452877A
GB1452877A GB2558375A GB2558375A GB1452877A GB 1452877 A GB1452877 A GB 1452877A GB 2558375 A GB2558375 A GB 2558375A GB 2558375 A GB2558375 A GB 2558375A GB 1452877 A GB1452877 A GB 1452877A
Authority
GB
United Kingdom
Prior art keywords
compounds
alkyl
hydropyrido
pyrimidines
tetra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2558375A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Publication of GB1452877A publication Critical patent/GB1452877A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1452877 Pyrido[2,3-d]pyrimidin- 2 - one derivatives HISAMITSU PHARMACEUTICAL CO Inc 16 June 1975 [5 July 1974] 25583/75 Heading C2C The invention comprises compounds of formula wherein R is Ph (optionally substituted by NO 2 CF 3 or by 1 or 2 of Me and halogen), and R<SP>1</SP> is H, C 1-6 alkyl, C 3-5 alkenyl, propargyl, cyclopropylmethyl, C 1-3 mono- or tri-haloalkyl, hydroxy-C 2-3 -alkyl, C 2-4 -(alkoxyalkyl), C 4-6 - (dialkylaminoalkyl), CO 2 Me, CO 2 Et or PhCH 2 . These compounds may be prepared by (1) introducing the substituent R<SP>1</SP>, (2) reducing a corresponding 4-thiono compound, or (3) forming the pyrimidinone ring. Therapeutic compositions having antiinflammatory, antiulcerative, analgetic, antipyretic, antihistaminic and/or C.N.S. depressant activity, comprise compounds of the above formula.
GB2558375A 1974-07-05 1975-06-16 2-oxo-1,2,3,4-tetra-hydropyrido-2,3,d-pyrimidines Expired GB1452877A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49080367A JPS58428B2 (en) 1974-07-05 1974-07-05 Synquina 2-oxo-1,2,3,4-tetrahydropyrido (2,3-D) Pyrimidine

Publications (1)

Publication Number Publication Date
GB1452877A true GB1452877A (en) 1976-10-20

Family

ID=13716283

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2558375A Expired GB1452877A (en) 1974-07-05 1975-06-16 2-oxo-1,2,3,4-tetra-hydropyrido-2,3,d-pyrimidines

Country Status (2)

Country Link
JP (1) JPS58428B2 (en)
GB (1) GB1452877A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019068A1 (en) * 1992-03-20 1993-09-30 Syntex (U.S.A.) Inc. PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019068A1 (en) * 1992-03-20 1993-09-30 Syntex (U.S.A.) Inc. PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
AU669520B2 (en) * 1992-03-20 1996-06-13 Syntex (U.S.A.) Inc. Pyrido(2,3-d)pyrimidine derivatives as phosphodiesterase inhibitors
EP1770093A1 (en) * 1992-03-20 2007-04-04 Roche Palo Alto LLC Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors

Also Published As

Publication number Publication date
JPS5113794A (en) 1976-02-03
JPS58428B2 (en) 1983-01-06

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee