GB1448980A - Unsymmetrically substituted bis-chromones - Google Patents
Unsymmetrically substituted bis-chromonesInfo
- Publication number
- GB1448980A GB1448980A GB286273*[A GB286273A GB1448980A GB 1448980 A GB1448980 A GB 1448980A GB 286273 A GB286273 A GB 286273A GB 1448980 A GB1448980 A GB 1448980A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- benzopyran
- compound
- oxo
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 3
- 239000002184 metal Substances 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IZQQYOMNCOIBHS-UHFFFAOYSA-M sodium;5-[2-hydroxy-3-(2-methoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate Chemical compound [Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=C2C(=O)C=C(C(=O)OC)OC2=CC=C1 IZQQYOMNCOIBHS-UHFFFAOYSA-M 0.000 abstract 2
- ZFOOLOKVAMJDQU-UHFFFAOYSA-N 5-[3-(2-cyano-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid Chemical compound C(#N)C=1OC2=C(C(C1)=O)C(=CC=C2)OCC(COC2=CC=CC1=C2C(C=C(O1)C(=O)O)=O)O ZFOOLOKVAMJDQU-UHFFFAOYSA-N 0.000 abstract 1
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- BKZKROMCXZSYQK-UHFFFAOYSA-M C(N)(=O)C=1OC2=C(C(C1)=O)C(=CC=C2)OCC(COC2=CC=CC1=C2C(C=C(O1)C(=O)[O-])=O)O.[Na+] Chemical compound C(N)(=O)C=1OC2=C(C(C1)=O)C(=CC=C2)OCC(COC2=CC=CC1=C2C(C=C(O1)C(=O)[O-])=O)O.[Na+] BKZKROMCXZSYQK-UHFFFAOYSA-M 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940125890 compound Ia Drugs 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB286273*[A GB1448980A (en) | 1973-01-19 | 1973-01-19 | Unsymmetrically substituted bis-chromones |
| IL43942A IL43942A0 (en) | 1973-01-19 | 1974-01-01 | Novel chromones,their preparation and pharmaceutical compositions containing them |
| AU64364/74A AU6436474A (en) | 1973-01-19 | 1974-01-09 | Compounds |
| FR7401092A FR2214473B1 (https=) | 1973-01-19 | 1974-01-14 | |
| DE2402274A DE2402274A1 (de) | 1973-01-19 | 1974-01-18 | Neue benzopyranverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| NL7400701A NL7400701A (https=) | 1973-01-19 | 1974-01-18 | |
| JP49008915A JPS49101378A (https=) | 1973-01-19 | 1974-01-19 | |
| US05/435,008 US3948954A (en) | 1973-01-19 | 1974-01-21 | Bis-chromone-tetrazole/hydroxamic/carboxylic acids |
| ES422413A ES422413A1 (es) | 1973-01-19 | 1976-03-18 | Procedimiento para preparar derivados de benzopirano. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB286173 | 1973-01-19 | ||
| GB286273*[A GB1448980A (en) | 1973-01-19 | 1973-01-19 | Unsymmetrically substituted bis-chromones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1448980A true GB1448980A (en) | 1976-09-08 |
Family
ID=26237797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB286273*[A Expired GB1448980A (en) | 1973-01-19 | 1973-01-19 | Unsymmetrically substituted bis-chromones |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS49101378A (https=) |
| AU (1) | AU6436474A (https=) |
| DE (1) | DE2402274A1 (https=) |
| ES (1) | ES422413A1 (https=) |
| FR (1) | FR2214473B1 (https=) |
| GB (1) | GB1448980A (https=) |
| IL (1) | IL43942A0 (https=) |
| NL (1) | NL7400701A (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2297040A1 (fr) * | 1975-01-13 | 1976-08-06 | Fisons Ltd | Procede et compositions pour le traitement de maladies gastro-intestinales |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1011744A (en) * | 1970-03-10 | 1977-06-07 | Allen And Hanburys Limited | Chromone derivatives |
| GB1324571A (en) * | 1971-01-22 | 1973-07-25 | Fisons Ltd | Thallium salts of hydroxy-chromones and the preparation of bis- chromones therefrom |
| GB1382247A (en) * | 1971-06-10 | 1975-01-29 | Fisons Ltd | Benzopyran derivatives |
-
1973
- 1973-01-19 GB GB286273*[A patent/GB1448980A/en not_active Expired
-
1974
- 1974-01-01 IL IL43942A patent/IL43942A0/xx unknown
- 1974-01-09 AU AU64364/74A patent/AU6436474A/en not_active Expired
- 1974-01-14 FR FR7401092A patent/FR2214473B1/fr not_active Expired
- 1974-01-18 NL NL7400701A patent/NL7400701A/xx unknown
- 1974-01-18 DE DE2402274A patent/DE2402274A1/de active Pending
- 1974-01-19 JP JP49008915A patent/JPS49101378A/ja active Pending
-
1976
- 1976-03-18 ES ES422413A patent/ES422413A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2214473A1 (https=) | 1974-08-19 |
| DE2402274A1 (de) | 1974-07-25 |
| JPS49101378A (https=) | 1974-09-25 |
| FR2214473B1 (https=) | 1977-04-22 |
| ES422413A1 (es) | 1976-11-01 |
| IL43942A0 (en) | 1974-05-16 |
| AU6436474A (en) | 1975-07-10 |
| NL7400701A (https=) | 1974-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |