GB1427939A - Process for the production of terpene hydroxyimino-amino deri vatives products thereby obtained and drugs comprising the same - Google Patents
Process for the production of terpene hydroxyimino-amino deri vatives products thereby obtained and drugs comprising the sameInfo
- Publication number
- GB1427939A GB1427939A GB3206973A GB3206973A GB1427939A GB 1427939 A GB1427939 A GB 1427939A GB 3206973 A GB3206973 A GB 3206973A GB 3206973 A GB3206973 A GB 3206973A GB 1427939 A GB1427939 A GB 1427939A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- terpene
- organic solvent
- hydroxylimino
- pinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1427939 α - Amino - # - oximino - terpenes CAMILLO CORVI SpA 5 July 1973 [14 July 1972] 32069/73 Heading C2C Terpene hydroximino-amino derivatives are prepared by reacting a terpene with cone. HCl in the presence of (a) at least one C 1-7 alkanol and an alkali-metal nitrite (b) at least one C 1-7 alkylnitrite or (c) at least one alkali metal nitrite in an organic acid medium of either concentrated formic or acetic acid to form a nitroso-chloride which is precipitated, purified and recrystallized and which is reacted stochiometrically with an amine derivative selected from ammonia or amines in an organic solvent at 50‹ to 80‹ C. for 2 to 7 hours; neutralizing the hydrochloric acid formed and purifying the hydroxylimino-amino base by recrystallization from an organic solvent or by distillation in the case of a liquid material. The organic solvent may be methanol, ethanol acetone or methyl ethyl ketone. The buffer is sodium or potassium acetate, cetrate or tartrate, a tertiary amine or an excess of the amine used in the reaction. Nitroso-chlorides of α-pinene, D-linonene, pinol, D,L-α-terpineol, #-terpineol, sylvestrene, #<SP>3</SP>- carene, and santene are prepared. The nitrosochloride of pinol is aminated with ammonia, diethylamine or piperidine. The hydroxylimino-amino terpenes exhibit choleretic activity and may be administered orally or parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2702172 | 1972-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1427939A true GB1427939A (en) | 1976-03-10 |
Family
ID=11220789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3206973A Expired GB1427939A (en) | 1972-07-14 | 1973-07-05 | Process for the production of terpene hydroxyimino-amino deri vatives products thereby obtained and drugs comprising the same |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS543872B2 (en) |
BE (1) | BE801844A (en) |
CH (1) | CH601207A5 (en) |
FR (1) | FR2310127A1 (en) |
GB (1) | GB1427939A (en) |
-
1973
- 1973-07-03 BE BE133063A patent/BE801844A/en not_active IP Right Cessation
- 1973-07-04 FR FR7324523A patent/FR2310127A1/en active Granted
- 1973-07-05 GB GB3206973A patent/GB1427939A/en not_active Expired
- 1973-07-13 CH CH1029973A patent/CH601207A5/xx not_active IP Right Cessation
- 1973-07-14 JP JP7975473A patent/JPS543872B2/ja not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2310127A1 (en) | 1976-12-03 |
DE2335665A1 (en) | 1974-01-31 |
DE2335665B2 (en) | 1976-02-26 |
FR2310127B1 (en) | 1978-07-07 |
JPS543872B2 (en) | 1979-02-27 |
CH601207A5 (en) | 1978-06-30 |
JPS5029529A (en) | 1975-03-25 |
BE801844A (en) | 1973-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1180749A (en) | A New Polycyclic Amine and Processes for its Production | |
GB1358358A (en) | N- -d-6-methyl-8-isoergolin-i-yl- n,n,-diethylurea and a method of preparing same | |
BE843413A (en) | PERFECTED PROCESS FOR THE PRODUCTION OF ACETIC ACID, ETHANOL AND ACETHALDEHYDE FROM SYNTHESIS GAS | |
FOX | Synthetic tuberculostats. I. Pyridine carboxylic acid derivatives | |
GB1427939A (en) | Process for the production of terpene hydroxyimino-amino deri vatives products thereby obtained and drugs comprising the same | |
US3795707A (en) | Manufacture of alpha-6-deoxytetracyclines | |
US2647904A (en) | Derivatives of tropic acid and proc | |
FR2317260A1 (en) | PROCESS FOR THE PRODUCTION OF ACETIC ACID, ETHANOL AND ACETALDEHYDE FROM SYNTHESIS GAS | |
Shirahata et al. | The Structures of Corynecins; Chloramphenicol Analogues Produced by an-Paraffin-grown Bacterium | |
US2606187A (en) | N-glycosido benzimidazoles and process for preparation | |
László et al. | Stereochemistry of the palladium (II) promoted carbocyclization of hex-5-enopyranosides | |
US2759942A (en) | Substituted piperidinecarboxylates and methods of preparing same | |
US3051710A (en) | Glycolic acid amide derivatives of piperazine and use thereof | |
GB1365770A (en) | Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof | |
GB1334125A (en) | Aminopropionanilides and a process for the preparation thereof | |
US3992416A (en) | 4-Oxa-5-hydroxypolycycloalkenones-(3) | |
TW301653B (en) | ||
GB1327745A (en) | Steroid glycosides and a process for their manufacture | |
GB1433558A (en) | Process for the preparation of diketones derivatives of glycyrrhetinic acid | |
JPS5331628A (en) | Isolation and purification of aromatic compounds with monohalogenated side chains | |
US3860630A (en) | Phenethylamide derivatives | |
US2588608A (en) | Delta 8,(14)-androstendiols and process | |
Winthrop et al. | 2-BENZHYDRYLIMINO-4-THIAZOLIDONES AND RELATED COMPOUNDS | |
US2839525A (en) | 3-aminoribose and method for its preparation | |
GB1368616A (en) | Pyrazole derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |