GB1420885A - Ocular drug dispensing device and process for making the same - Google Patents

Ocular drug dispensing device and process for making the same

Info

Publication number
GB1420885A
GB1420885A GB383774A GB383774A GB1420885A GB 1420885 A GB1420885 A GB 1420885A GB 383774 A GB383774 A GB 383774A GB 383774 A GB383774 A GB 383774A GB 1420885 A GB1420885 A GB 1420885A
Authority
GB
United Kingdom
Prior art keywords
drug
eye
walls
given
examples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB383774A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of GB1420885A publication Critical patent/GB1420885A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants

Abstract

1420885 Administering drugs to the eye; pharmaceutical preparations ALZA CORP 28 Jan 1974 03837/74 Headings A5B and A5R A drug is dispensed to an eye at a predetermined rate for a prolonged period of time by a sealed container 10 insertable in a cul-de-sac of the eye and having first and third walls 11, 14, each insoluble in tear fluid and at least one being permeable to the drug by diffusion, separated by an annular second wall 12, with a drug mixture 13 comprising a drug and carrier in the interior space 15 formed by the walls 11, 12, 14. The permeable wall(s) may comprise a homogeneous imperforate natural or synthetic polymer, of which examples are given, e.g. natural rubber, silicone rubber, plasticised nylon, polymethylmethacrylate, or ethylene-vinylacetate copolymer. Alternatively the permeable walls may comprise microporous material with pore sizes from 10Š to 100 microns, of which examples are given, e.g. celluloses, cellulose acetate propionate or polycarbonates, filled with a diffusive medium in which the drug has a limited solubility, of which several examples are given, e.g. water, glycerin or propylene glycol. The second wall 12 comprises a cold or hot setting adhesive polymeric material (setting temperature 5‹C to 250‹C) heat sealed to the walls 11, 14, examples of materials being given, e.g. polyvinylacetate or polyamides, and may include a dye for identification purposes. The drug may comprise antibiotics e.g. tetracycline, antibacterials e.g. sulfonamides, antivirals e.g. idoxuridine, anti-allergenics e.g. antazoline, antiinflammatories e.g. hydrocortisone, decongestants e.g. phenylephrine, miotics and anticholinesterases e.g. pilocarpine, mydriatics e.g. atropine sulfate, or sympathomimetics e.g. epinephrine, suspended in a solid or semi-solid carrier, e.g. gelatin, starches, pectin &c. The device may be of various shapes, e.g. elliptical, bean-shaped, banana-shaped, circular, rectangular, trapezoidal or doughnut shaped, for retention in the eye.
GB383774A 1974-02-15 1974-01-28 Ocular drug dispensing device and process for making the same Expired GB1420885A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742407276 DE2407276C3 (en) 1974-02-15 1974-02-15 Method of making a long-term drug delivery device for the eye

Publications (1)

Publication Number Publication Date
GB1420885A true GB1420885A (en) 1976-01-14

Family

ID=5907519

Family Applications (1)

Application Number Title Priority Date Filing Date
GB383774A Expired GB1420885A (en) 1974-02-15 1974-01-28 Ocular drug dispensing device and process for making the same

Country Status (4)

Country Link
AU (1) AU478188B2 (en)
CH (1) CH575766A5 (en)
DE (1) DE2407276C3 (en)
GB (1) GB1420885A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725272A (en) * 1981-06-29 1988-02-16 Alza Corporation Novel bandage for administering beneficial drug
DE3204582A1 (en) * 1982-02-10 1983-08-25 Hassia Verpackung Gmbh, 6479 Ranstadt Method of continuously producing plaster packs for transdermal administration of medicaments

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules

Also Published As

Publication number Publication date
AU478188B2 (en) 1975-08-07
AU6512574A (en) 1975-08-07
DE2407276C3 (en) 1979-10-18
CH575766A5 (en) 1976-05-31
DE2407276A1 (en) 1975-08-28
DE2407276B2 (en) 1979-02-22

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee