GB1416749A - Xanthene and thioxanthene derivatives - Google Patents
Xanthene and thioxanthene derivativesInfo
- Publication number
- GB1416749A GB1416749A GB5825873A GB5825873A GB1416749A GB 1416749 A GB1416749 A GB 1416749A GB 5825873 A GB5825873 A GB 5825873A GB 5825873 A GB5825873 A GB 5825873A GB 1416749 A GB1416749 A GB 1416749A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- xanthene
- dec
- thioxanthene derivatives
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 title abstract 2
- 229940054058 antipsychotic thioxanthene derivative Drugs 0.000 title abstract 2
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 title abstract 2
- 150000005075 thioxanthenes Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical compound C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
1416749 Xanthene and thioxanthene derivatives RICHARDSON-MERRELL Inc 17 Dec 1973 [21 Dec 1972] 58258/73 Heading C2C Novel compounds of Formula I where Y is oxygen or sulphur; A is a straight or branched alkylene chain having from 1 to 4 carbon atoms; R and R 1 are each hydrogen, lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl having from 3 to 6 carbon atoms in which the unsaturation is in a position other than in the 1-position of the alkenyl group, and when R and R 1 are taken together with the nitrogen atom to which they are attached represent the pyrrolidinyl, morpholino or piperidino radical; and the pharmaceutically acceptable acid addition salts thereof are prepared by dehydration of the intermediates of Formula III whose preparation is described in Specification 1,416,750. Antiviral compositions in conventional forms for oral, topical or parenteral administration comprise an above novel compound and a carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00317128A US3817992A (en) | 1972-12-21 | 1972-12-21 | Xanthene and thioxanthene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1416749A true GB1416749A (en) | 1975-12-03 |
Family
ID=23232235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5825873A Expired GB1416749A (en) | 1972-12-21 | 1973-12-17 | Xanthene and thioxanthene derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3817992A (en) |
| JP (1) | JPS4988874A (en) |
| AU (1) | AU476380B2 (en) |
| CA (1) | CA1018973A (en) |
| DE (1) | DE2362695A1 (en) |
| FR (1) | FR2211233B1 (en) |
| GB (1) | GB1416749A (en) |
| IL (1) | IL43665A (en) |
| ZA (1) | ZA738215B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004531474A (en) | 2001-01-16 | 2004-10-14 | ギルフォード ファーマシューティカルズ インコーポレイテッド | Pharmaceutical compositions for inhibiting symmetrically disubstituted aromatic compounds and poly (ADP-ribose) glycohydrolase, and methods of using them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3859286A (en) * | 1970-12-11 | 1975-01-07 | Richardson Merrell Inc | Bis-basic ketones of xanthene and xanthen-9-one |
| US3856789A (en) * | 1971-04-23 | 1974-12-24 | Richardson Merrell Inc | Bis-basic ketones of thioxanthene |
-
1972
- 1972-12-21 US US00317128A patent/US3817992A/en not_active Expired - Lifetime
-
1973
- 1973-10-23 ZA ZA738215*A patent/ZA738215B/en unknown
- 1973-10-26 AU AU61884/73A patent/AU476380B2/en not_active Expired
- 1973-10-29 CA CA184,442A patent/CA1018973A/en not_active Expired
- 1973-11-21 IL IL43665A patent/IL43665A/en unknown
- 1973-12-17 DE DE2362695A patent/DE2362695A1/en not_active Withdrawn
- 1973-12-17 GB GB5825873A patent/GB1416749A/en not_active Expired
- 1973-12-19 FR FR7345509A patent/FR2211233B1/fr not_active Expired
- 1973-12-20 JP JP48141917A patent/JPS4988874A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL43665A (en) | 1977-05-31 |
| AU6188473A (en) | 1975-05-01 |
| CA1018973A (en) | 1977-10-11 |
| JPS4988874A (en) | 1974-08-24 |
| AU476380B2 (en) | 1976-09-16 |
| US3817992A (en) | 1974-06-18 |
| FR2211233A1 (en) | 1974-07-19 |
| FR2211233B1 (en) | 1977-01-28 |
| DE2362695A1 (en) | 1974-06-27 |
| ZA738215B (en) | 1974-08-28 |
| IL43665A0 (en) | 1974-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |