GB1410371A - Substituted azetidinones - Google Patents

Substituted azetidinones

Info

Publication number
GB1410371A
GB1410371A GB420272A GB420272A GB1410371A GB 1410371 A GB1410371 A GB 1410371A GB 420272 A GB420272 A GB 420272A GB 420272 A GB420272 A GB 420272A GB 1410371 A GB1410371 A GB 1410371A
Authority
GB
United Kingdom
Prior art keywords
compound
optionally substituted
jan
carbon atoms
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB420272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE794659D priority Critical patent/BE794659A/en
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB420272A priority patent/GB1410371A/en
Priority to AU51525/73A priority patent/AU5152573A/en
Priority to FR7302758A priority patent/FR2169300B1/fr
Priority to CH117473A priority patent/CH597181A5/xx
Priority to DE19732303889 priority patent/DE2303889A1/en
Priority to NL7301143A priority patent/NL7301143A/xx
Priority to ES411038A priority patent/ES411038A1/en
Priority to JP48011510A priority patent/JPS4881849A/ja
Publication of GB1410371A publication Critical patent/GB1410371A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3

Abstract

1410371 Substituted azetidinones GLAXO LABORATORIES Ltd 23 Jan 1973 [28 Jan 1972] 4202/72 Heading C2C Substituted azetidinones of the Formula I wherein R<SP>1</SP> represents a group RCONH where R is a hydrogen atom or an organic group containing from 1 to 20 carbon atoms; R<SP>2</SP> represents a hydrogen atom or an optionally substituted aliphatic, araliphatic, aromatic or an optionally substituted acyl group and R<SP>3</SP> represents an optionally substituted hydrocarbyl group containing from 1 to 20 carbon atoms comprises reacting a compound of formulae with a compound of formula R<SP>3</SP>SX wherein X is a readily eliminable substituent in the presence of a protic compound. Prefer- X is Cl or Br and the molar ratio of sulphide to heterocyclic compound is from 1 : 1 to 10 : 1. The cleavage may be effected at a temperature of from - 50‹ to 110‹ C. The R<SP>3</SP>SX may be generated in situ.
GB420272A 1972-01-28 1972-01-28 Substituted azetidinones Expired GB1410371A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BE794659D BE794659A (en) 1972-01-28 PROCESS FOR PREPARING INTERMEDIATE COMPOUNDS FOR OBTAINING BETA-LACTAM TYPE ANTIBIOTICS
GB420272A GB1410371A (en) 1972-01-28 1972-01-28 Substituted azetidinones
AU51525/73A AU5152573A (en) 1972-01-28 1973-01-26 Chemical compounds
FR7302758A FR2169300B1 (en) 1972-01-28 1973-01-26
CH117473A CH597181A5 (en) 1972-01-28 1973-01-26
DE19732303889 DE2303889A1 (en) 1972-01-28 1973-01-26 ANTIBIOTICS
NL7301143A NL7301143A (en) 1972-01-28 1973-01-26
ES411038A ES411038A1 (en) 1972-01-28 1973-01-27 Substituted azetidinones
JP48011510A JPS4881849A (en) 1972-01-28 1973-01-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB420272A GB1410371A (en) 1972-01-28 1972-01-28 Substituted azetidinones

Publications (1)

Publication Number Publication Date
GB1410371A true GB1410371A (en) 1975-10-15

Family

ID=9772650

Family Applications (1)

Application Number Title Priority Date Filing Date
GB420272A Expired GB1410371A (en) 1972-01-28 1972-01-28 Substituted azetidinones

Country Status (9)

Country Link
JP (1) JPS4881849A (en)
AU (1) AU5152573A (en)
BE (1) BE794659A (en)
CH (1) CH597181A5 (en)
DE (1) DE2303889A1 (en)
ES (1) ES411038A1 (en)
FR (1) FR2169300B1 (en)
GB (1) GB1410371A (en)
NL (1) NL7301143A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117875A1 (en) * 1982-09-06 1984-09-12 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing azetidinone derivatives
US4532077A (en) * 1982-08-25 1985-07-30 Otsuka Kagaku Yakuhin Kabushiki Kaisha Thiazolineazetidinone-type compounds

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7411505A (en) * 1973-09-06 1975-03-10 Rhone Poulenc Sa PROCEDURE FOR THE PREPARATION AND USE OF NEW 7-TRICHLORACETAMIDO-3-DESACETOXY-CEFA-LOSPORANIC ACID PREPARATIONS.
JPS5817460B2 (en) * 1975-03-20 1983-04-07 塩野義製薬株式会社 Thiazoline Kanno Kaikanhouhou
NL7806860A (en) * 1977-07-05 1979-01-09 Farmaceutici Italia PROCESS FOR PREPARING NOCARDICIN-RELATED AZETIDINONES.
US4482491A (en) * 1981-05-01 1984-11-13 Otsuka Kagaku Yakuhin Kabushiki Kaisha Thiazolinoazetidinone derivatives and process for the preparation of the same
JPS59101485A (en) * 1982-11-29 1984-06-12 Otsuka Chem Co Ltd Azetidinone derivative and its preparation
JPS59134779A (en) * 1983-01-19 1984-08-02 Otsuka Chem Co Ltd Preparation of azetidinone derivative
JPH0623189B2 (en) * 1988-05-19 1994-03-30 大塚化学薬品株式会社 Process for producing azetidinone derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1368234A (en) * 1970-11-03 1974-09-25 Glaxo Lab Ltd Thiosubstituted szetidinones and other antibiotic precursors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532077A (en) * 1982-08-25 1985-07-30 Otsuka Kagaku Yakuhin Kabushiki Kaisha Thiazolineazetidinone-type compounds
EP0117875A1 (en) * 1982-09-06 1984-09-12 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing azetidinone derivatives
US4622178A (en) * 1982-09-06 1986-11-11 Otsuka Kagaku Kabushiki Kaisha Process for preparing azetidinone derivatives
EP0117875B1 (en) * 1982-09-06 1987-07-22 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing azetidinone derivatives

Also Published As

Publication number Publication date
FR2169300B1 (en) 1978-08-04
NL7301143A (en) 1973-07-31
AU5152573A (en) 1974-08-01
FR2169300A1 (en) 1973-09-07
CH597181A5 (en) 1978-03-31
ES411038A1 (en) 1975-12-01
DE2303889A1 (en) 1973-08-02
BE794659A (en) 1973-07-30
JPS4881849A (en) 1973-11-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee