GB1374370A - Dioxathiocin-carboxylic acids esters and mides - Google Patents
Dioxathiocin-carboxylic acids esters and midesInfo
- Publication number
- GB1374370A GB1374370A GB3933272A GB3933272A GB1374370A GB 1374370 A GB1374370 A GB 1374370A GB 3933272 A GB3933272 A GB 3933272A GB 3933272 A GB3933272 A GB 3933272A GB 1374370 A GB1374370 A GB 1374370A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- salt
- naphtho
- benzo
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000005605 benzo group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000001315 anti-hyperlipaemic effect Effects 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 pyrrolidino, piperidino, morpholino, piperazino Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1374370 Di(benzo or naphtho)dioxathiocines RICHARDSON-MERRELL Inc 23 Aug 1972 [13 Sept 1971] 39332/72 Heading C2C Novel di(benzo or naphtho)dioxathiocines of the general formula wherein each Y, Y<SP>1</SP>, Z and Z<SP>1</SP> is a hydrogen or halogen atom or C 1-4 alkyl group or each set of Y and Y<SP>1</SP> or each set of Z and Z<SP>1</SP>, taken together with the aromatic ring to which each set is attached, forms a naphthalene ring optionally substituted by a halogen atom or C 1-4 alkyl group and W is a hydroxy, C 1-4 alkoxy or -NR<SP>1</SP>R<SP>2</SP> group (wherein each of R<SP>1</SP> and R<SP>2</SP> is a hydrogen atom or C 1-4 alkyl group or NR<SP>1</SP>R<SP>2</SP> is a pyrrolidino, piperidino, morpholino, piperazino or N- (C 1-4 alkyl)-piperazino group, are prepared by reacting one equivalent of a compound of the general formula or a salt thereof with at least two equivalents of a dihaloacetate salt in the presence of a solvent and excess base, suspending the obtained salt of the general formula wherein M is an inorganic salt-forming radical, in water and acidifying, followed optionally by subjecting the free acid product to esterification with a C 1-4 alkanol or reaction with thionyl chloride, followed by treatment of the obtained acid chloride with ammonia or the appropriate amine. Pharmaceutical compositions having anti-hyperlipidemic and anti-infective activity comprise, as active ingredient, a di(benzo or naphtho)dioxathiocine of the first general formula above, together with a pharmaceutically acceptable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18011771A | 1971-09-13 | 1971-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1374370A true GB1374370A (en) | 1974-11-20 |
Family
ID=22659258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3933272A Expired GB1374370A (en) | 1971-09-13 | 1972-08-23 | Dioxathiocin-carboxylic acids esters and mides |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3714191A (en) |
| JP (1) | JPS5543473B2 (en) |
| AU (1) | AU458572B2 (en) |
| BE (1) | BE788770A (en) |
| CA (1) | CA1016182A (en) |
| CH (1) | CH569728A5 (en) |
| DE (1) | DE2242841A1 (en) |
| FR (1) | FR2154491B1 (en) |
| GB (1) | GB1374370A (en) |
| NL (1) | NL7212396A (en) |
| ZA (1) | ZA725744B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3553234A (en) * | 1969-06-18 | 1971-01-05 | Richardson Merrell Inc | Dibenzo(d,g)(1,3)dioxocin-6-carboxylic acids, esters and salts |
-
0
- BE BE788770D patent/BE788770A/en unknown
-
1971
- 1971-09-13 US US00180117A patent/US3714191A/en not_active Expired - Lifetime
-
1972
- 1972-08-21 ZA ZA725744A patent/ZA725744B/en unknown
- 1972-08-23 CA CA150,042A patent/CA1016182A/en not_active Expired
- 1972-08-23 GB GB3933272A patent/GB1374370A/en not_active Expired
- 1972-08-24 AU AU45924/72A patent/AU458572B2/en not_active Expired
- 1972-08-31 DE DE2242841A patent/DE2242841A1/en active Pending
- 1972-09-01 JP JP8719372A patent/JPS5543473B2/ja not_active Expired
- 1972-09-05 CH CH1304772A patent/CH569728A5/xx not_active IP Right Cessation
- 1972-09-11 FR FR7232145A patent/FR2154491B1/fr not_active Expired
- 1972-09-13 NL NL7212396A patent/NL7212396A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4592472A (en) | 1974-02-28 |
| FR2154491B1 (en) | 1975-08-08 |
| NL7212396A (en) | 1973-03-15 |
| CH569728A5 (en) | 1975-11-28 |
| JPS4836184A (en) | 1973-05-28 |
| AU458572B2 (en) | 1975-02-27 |
| JPS5543473B2 (en) | 1980-11-06 |
| FR2154491A1 (en) | 1973-05-11 |
| US3714191A (en) | 1973-01-30 |
| CA1016182A (en) | 1977-08-23 |
| BE788770A (en) | 1973-01-02 |
| ZA725744B (en) | 1973-05-30 |
| DE2242841A1 (en) | 1973-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |