GB1374370A - Dioxathiocin-carboxylic acids esters and mides - Google Patents

Dioxathiocin-carboxylic acids esters and mides

Info

Publication number
GB1374370A
GB1374370A GB3933272A GB3933272A GB1374370A GB 1374370 A GB1374370 A GB 1374370A GB 3933272 A GB3933272 A GB 3933272A GB 3933272 A GB3933272 A GB 3933272A GB 1374370 A GB1374370 A GB 1374370A
Authority
GB
United Kingdom
Prior art keywords
general formula
salt
naphtho
benzo
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3933272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of GB1374370A publication Critical patent/GB1374370A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1374370 Di(benzo or naphtho)dioxathiocines RICHARDSON-MERRELL Inc 23 Aug 1972 [13 Sept 1971] 39332/72 Heading C2C Novel di(benzo or naphtho)dioxathiocines of the general formula wherein each Y, Y<SP>1</SP>, Z and Z<SP>1</SP> is a hydrogen or halogen atom or C 1-4 alkyl group or each set of Y and Y<SP>1</SP> or each set of Z and Z<SP>1</SP>, taken together with the aromatic ring to which each set is attached, forms a naphthalene ring optionally substituted by a halogen atom or C 1-4 alkyl group and W is a hydroxy, C 1-4 alkoxy or -NR<SP>1</SP>R<SP>2</SP> group (wherein each of R<SP>1</SP> and R<SP>2</SP> is a hydrogen atom or C 1-4 alkyl group or NR<SP>1</SP>R<SP>2</SP> is a pyrrolidino, piperidino, morpholino, piperazino or N- (C 1-4 alkyl)-piperazino group, are prepared by reacting one equivalent of a compound of the general formula or a salt thereof with at least two equivalents of a dihaloacetate salt in the presence of a solvent and excess base, suspending the obtained salt of the general formula wherein M is an inorganic salt-forming radical, in water and acidifying, followed optionally by subjecting the free acid product to esterification with a C 1-4 alkanol or reaction with thionyl chloride, followed by treatment of the obtained acid chloride with ammonia or the appropriate amine. Pharmaceutical compositions having anti-hyperlipidemic and anti-infective activity comprise, as active ingredient, a di(benzo or naphtho)dioxathiocine of the first general formula above, together with a pharmaceutically acceptable carrier.
GB3933272A 1971-09-13 1972-08-23 Dioxathiocin-carboxylic acids esters and mides Expired GB1374370A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18011771A 1971-09-13 1971-09-13

Publications (1)

Publication Number Publication Date
GB1374370A true GB1374370A (en) 1974-11-20

Family

ID=22659258

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3933272A Expired GB1374370A (en) 1971-09-13 1972-08-23 Dioxathiocin-carboxylic acids esters and mides

Country Status (11)

Country Link
US (1) US3714191A (en)
JP (1) JPS5543473B2 (en)
AU (1) AU458572B2 (en)
BE (1) BE788770A (en)
CA (1) CA1016182A (en)
CH (1) CH569728A5 (en)
DE (1) DE2242841A1 (en)
FR (1) FR2154491B1 (en)
GB (1) GB1374370A (en)
NL (1) NL7212396A (en)
ZA (1) ZA725744B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553234A (en) * 1969-06-18 1971-01-05 Richardson Merrell Inc Dibenzo(d,g)(1,3)dioxocin-6-carboxylic acids, esters and salts

Also Published As

Publication number Publication date
AU458572B2 (en) 1975-02-27
JPS5543473B2 (en) 1980-11-06
NL7212396A (en) 1973-03-15
FR2154491A1 (en) 1973-05-11
ZA725744B (en) 1973-05-30
CA1016182A (en) 1977-08-23
US3714191A (en) 1973-01-30
CH569728A5 (en) 1975-11-28
AU4592472A (en) 1974-02-28
DE2242841A1 (en) 1973-03-22
FR2154491B1 (en) 1975-08-08
BE788770A (en) 1973-01-02
JPS4836184A (en) 1973-05-28

Similar Documents

Publication Publication Date Title
GB1069343A (en) Propanolamine derivatives
ES344357A1 (en) Cyclopropanecarboxylic acid esters
GEP19960467B (en) Method of producing derivatives of quinoline or their pharmaceutically acceptable esters or acid-additive salts
HUT52059A (en) Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
GB1466646A (en) Substituted benzamides
GB1269551A (en) New tricyclic derivatives and process for their manufacture
GB1380225A (en) Biphenylyl- alkanoylaminopyridines and acid addition salts thereof
GB1369248A (en) Amides the preparation thereof and their use in pharmacjeutical compositions
GB1446221A (en) Discarboxylic acid derivatives and processes for their manufactur
GB1265279A (en)
GB1342558A (en) Substituted 3-benzylpyridines
GB1392908A (en) Salts thereof
GB1462036A (en) Aminoindane derivatives
GB1374370A (en) Dioxathiocin-carboxylic acids esters and mides
GB1383888A (en) Amino ether derivatives of orthothymatic esters
GB1449802A (en) Piperazine derivatives and compositions containing them for treating parkinsons disease
GB1466822A (en) Substituted benzamides
GB1441872A (en) Nitrobenzophenones
GB1441873A (en) Diamino-benzophenones
ES426771A1 (en) Aminopropanol substituted isochromanones and phthalides
GB1421580A (en) Production of benzylamine derivatives
GB1462676A (en) Substituted esters of n-4-quinolyl-anthranilic acids
GB1242096A (en) Benzobenzofuranooxepine compounds and process for preparing the same
GB1214077A (en) Oximes and their carbamoyl esters and the methods of preparation thereof
GB1311543A (en) Basically substituted 2,4-1h,3h-quinazolindione derivatives and processes for the production thereof

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee