GB1373352A - Oxazole derivatives - Google Patents

Oxazole derivatives

Info

Publication number
GB1373352A
GB1373352A GB1192871A GB1192871A GB1373352A GB 1373352 A GB1373352 A GB 1373352A GB 1192871 A GB1192871 A GB 1192871A GB 1192871 A GB1192871 A GB 1192871A GB 1373352 A GB1373352 A GB 1373352A
Authority
GB
United Kingdom
Prior art keywords
general formula
ester
propionic acid
dichlorobenzoin
diphenyloxazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1192871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB1192871A priority Critical patent/GB1373352A/en
Publication of GB1373352A publication Critical patent/GB1373352A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1373352 3-(4,5-Di-phenyloxazol-2-yl)propionic acid derivatives JOHN WYETH & BRO Ltd 27 April 1972 [28 April 1971] 11928/71 Addition to 1206403 Heading C2C Novel 3-(4,5-diphenyloxazol-2-yl)propionic acid derivatives of the general formula wherein X is F or Cl and Y is OH, NH 2 , alkoxy or OM (M is an alkali or alkaline earth metal ion, the ammonium ion or an ion of an organic base), are prepared by reaction of a keto-ester of the general formula wherein Y<SP>1</SP> is OH or alkoxy, with ammonia or a salt thereof or urea and optional conversion of the resulting acid or ester to a corresponding amide or salt by a method known per se. An N - (1,2 - diphenylethan - 2 - one) - succinamic acid formed in the process may be cyclized to the desired product with sulphuric acid. 4,4<SP>1</SP>-Dichlorobenzoin hemisuccinate ester is prepared by reaction of 4,4<SP>1</SP>-dichlorobenzoin with succinic anhydride. Pharmaceutical compositions having antiinflammatory activity comprise, as active ingredient, a 3-(4,5-diphenyloxazol-2-yl)propionic acid derivative of the first general formula above, together with a pharmaceutically acceptable carrier.
GB1192871A 1972-04-27 1972-04-27 Oxazole derivatives Expired GB1373352A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1192871A GB1373352A (en) 1972-04-27 1972-04-27 Oxazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1192871A GB1373352A (en) 1972-04-27 1972-04-27 Oxazole derivatives

Publications (1)

Publication Number Publication Date
GB1373352A true GB1373352A (en) 1974-11-13

Family

ID=9995223

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1192871A Expired GB1373352A (en) 1972-04-27 1972-04-27 Oxazole derivatives

Country Status (1)

Country Link
GB (1) GB1373352A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663331A1 (en) * 1990-06-14 1991-12-20 Bellon Labor Sa Roger NEW OXAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663331A1 (en) * 1990-06-14 1991-12-20 Bellon Labor Sa Roger NEW OXAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
WO1991019714A1 (en) * 1990-06-14 1991-12-26 Laboratoire Roger Bellon Novel oxazole derivatives, a preparation method therefor and pharmaceutical compositions containing same

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years