GB1373346A - Biologically active imidazoles - Google Patents
Biologically active imidazolesInfo
- Publication number
- GB1373346A GB1373346A GB5838570A GB5838570A GB1373346A GB 1373346 A GB1373346 A GB 1373346A GB 5838570 A GB5838570 A GB 5838570A GB 5838570 A GB5838570 A GB 5838570A GB 1373346 A GB1373346 A GB 1373346A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- optionally substituted
- general formula
- amino
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000012954 diazonium Substances 0.000 abstract 2
- 150000001989 diazonium salts Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000006193 diazotization reaction Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- JYGRVMQGWVVHJE-UHFFFAOYSA-N ethyl 2-amino-2-cyanoacetate Chemical compound CCOC(=O)C(N)C#N JYGRVMQGWVVHJE-UHFFFAOYSA-N 0.000 abstract 1
- QWFPFDAMUKCWPU-UHFFFAOYSA-N ethyl 4-amino-2-phenyl-1h-imidazole-5-carboxylate;hydrochloride Chemical compound Cl.NC1=C(C(=O)OCC)NC(C=2C=CC=CC=2)=N1 QWFPFDAMUKCWPU-UHFFFAOYSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000007614 solvation Methods 0.000 abstract 1
- 125000001302 tertiary amino group Chemical group 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
- -1 α-iminobenzylbenzyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5838570A GB1373346A (en) | 1970-12-09 | 1970-12-09 | Biologically active imidazoles |
| IE1448/71A IE35817B1 (en) | 1970-12-09 | 1971-11-17 | Novel biologically active imidazoles |
| IL38174A IL38174A0 (en) | 1970-12-09 | 1971-11-18 | Substituted imidazoles,their preparation and pharmaceutical compositions containing them |
| ZA717873A ZA717873B (en) | 1970-12-09 | 1971-11-23 | Novel imidazole compounds |
| NL7116331A NL7116331A (enrdf_load_stackoverflow) | 1970-12-09 | 1971-11-26 | |
| CA128,705A CA979428A (en) | 1970-12-09 | 1971-11-26 | Imidazole compounds |
| ES397573A ES397573A1 (es) | 1970-12-09 | 1971-12-01 | Un procedimiento para la preparacion de nuevos imidazoles sustituidos. |
| AT1042171A AT310740B (de) | 1970-12-09 | 1971-12-03 | Verfahren zur Herstellung von neuen Imidazolderivaten |
| AU36588/71A AU457263B2 (en) | 1971-12-07 | 2-aromatic carbocyclyl or heterocyclyl-imidazoles | |
| FR7144014A FR2117939B1 (enrdf_load_stackoverflow) | 1970-12-09 | 1971-12-08 | |
| BE776422A BE776422A (fr) | 1970-12-09 | 1971-12-08 | Triazenoimidazoles |
| DE19712161209 DE2161209A1 (de) | 1970-12-09 | 1971-12-09 | Substituierte Imidazole, ihre pharmakologisch verträglichen Salze, Verfahren zu ihrer Herstellung, und diese Verbindungen enthaltende Arzneipräparate |
| HUBE1108A HU163484B (enrdf_load_stackoverflow) | 1970-12-09 | 1971-12-09 | |
| SE7412430A SE7412430L (enrdf_load_stackoverflow) | 1970-12-09 | 1974-10-02 | |
| US05/527,581 US3997518A (en) | 1970-12-09 | 1974-11-27 | 2-Alkyl-4-carboxyalkyl-5-(3,3'-dimethyltriazeno)-imidazoles |
| US05/527,655 US3956262A (en) | 1970-12-09 | 1974-11-27 | Triazenoimidazoles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5838570A GB1373346A (en) | 1970-12-09 | 1970-12-09 | Biologically active imidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1373346A true GB1373346A (en) | 1974-11-13 |
Family
ID=10481482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5838570A Expired GB1373346A (en) | 1970-12-09 | 1970-12-09 | Biologically active imidazoles |
Country Status (13)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3720437A4 (en) * | 2017-12-06 | 2021-11-03 | Yale University | MEDICINAL PRODUCTS ACTIVATED BY REDUCTION IN CYTOSOL |
-
1970
- 1970-12-09 GB GB5838570A patent/GB1373346A/en not_active Expired
-
1971
- 1971-11-17 IE IE1448/71A patent/IE35817B1/xx unknown
- 1971-11-18 IL IL38174A patent/IL38174A0/xx unknown
- 1971-11-23 ZA ZA717873A patent/ZA717873B/xx unknown
- 1971-11-26 CA CA128,705A patent/CA979428A/en not_active Expired
- 1971-11-26 NL NL7116331A patent/NL7116331A/xx unknown
- 1971-12-01 ES ES397573A patent/ES397573A1/es not_active Expired
- 1971-12-03 AT AT1042171A patent/AT310740B/de not_active IP Right Cessation
- 1971-12-08 FR FR7144014A patent/FR2117939B1/fr not_active Expired
- 1971-12-08 BE BE776422A patent/BE776422A/xx unknown
- 1971-12-09 HU HUBE1108A patent/HU163484B/hu unknown
- 1971-12-09 DE DE19712161209 patent/DE2161209A1/de active Pending
-
1974
- 1974-10-02 SE SE7412430A patent/SE7412430L/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BE776422A (fr) | 1972-06-08 |
| IE35817B1 (en) | 1976-05-26 |
| ES397573A1 (es) | 1975-10-01 |
| IE35817L (en) | 1972-06-09 |
| AT310740B (de) | 1973-10-10 |
| IL38174A0 (en) | 1972-01-27 |
| SE7412430L (enrdf_load_stackoverflow) | 1974-10-02 |
| CA979428A (en) | 1975-12-09 |
| NL7116331A (enrdf_load_stackoverflow) | 1972-06-13 |
| ZA717873B (en) | 1972-08-30 |
| FR2117939A1 (enrdf_load_stackoverflow) | 1972-07-28 |
| HU163484B (enrdf_load_stackoverflow) | 1973-09-27 |
| FR2117939B1 (enrdf_load_stackoverflow) | 1975-06-13 |
| AU3658871A (en) | 1973-06-14 |
| DE2161209A1 (de) | 1972-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |