GB1353162A - 17alpha-propadienyl steroids - Google Patents
17alpha-propadienyl steroidsInfo
- Publication number
- GB1353162A GB1353162A GB1523771A GB1523771A GB1353162A GB 1353162 A GB1353162 A GB 1353162A GB 1523771 A GB1523771 A GB 1523771A GB 1523771 A GB1523771 A GB 1523771A GB 1353162 A GB1353162 A GB 1353162A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- methyl
- ethylenedioxyestra
- trien
- methylestra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- -1 3,3-ethylenedioxy- Chemical class 0.000 abstract 3
- 229910010082 LiAlH Inorganic materials 0.000 abstract 3
- BYNNHDXNSFRECH-JYAXBFRTSA-N (8'S,9'S,13'S,14'S)-3'-methoxy-9',13'-dimethylspiro[1,3-dioxolane-2,17'-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene]-11'-one Chemical compound C1OC2([C@]3(C)[C@@H](CC2)[C@@H]2CCC=4C=C(C=CC4[C@]2(C(C3)=O)C)OC)OC1 BYNNHDXNSFRECH-JYAXBFRTSA-N 0.000 abstract 2
- DNAYTCUJACDUSG-XEYPJELSSA-N (8s,9s,13s,14s)-3-methoxy-9,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-one Chemical compound C1C[C@]2(C)C3=CC=C(OC)C=C3CC[C@H]2[C@@H]2CCC(=O)[C@]21C DNAYTCUJACDUSG-XEYPJELSSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- URRKDAJPRNSBHD-XEYPJELSSA-N (8'S,9'S,13'S,14'S)-3'-methoxy-13'-methylspiro[1,3-dioxolane-2,17'-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene]-11'-one Chemical compound C1OC2([C@]3(C)[C@@H](CC2)[C@@H]2CCC=4C=C(C=CC4[C@H]2C(C3)=O)OC)OC1 URRKDAJPRNSBHD-XEYPJELSSA-N 0.000 abstract 1
- FVDMEZWDZIOFPK-BURNTYAHSA-N (8'S,9'S,13'S,14'S)-3'-methoxy-9',13'-dimethylspiro[1,3-dioxolane-2,17'-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene] Chemical compound C1OC2([C@]3(C)[C@@H](CC2)[C@@H]2CCC=4C=C(C=CC=4[C@]2(CC3)C)OC)OC1 FVDMEZWDZIOFPK-BURNTYAHSA-N 0.000 abstract 1
- ZYEPWFOAZRKWFN-ZRNYENFQSA-N (8'r,9's,13's,14's)-3'-methoxy-13'-methylspiro[1,3-dioxolane-2,17'-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene] Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3C4=CC=C(C=C4CC[C@H]31)OC)CC21OCCO1 ZYEPWFOAZRKWFN-ZRNYENFQSA-N 0.000 abstract 1
- KXRKCBBFKAQZRL-XEYPJELSSA-N (8s,9s,13s,14s)-3-methoxy-9,13-dimethyl-1,4,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-one Chemical compound C1C[C@]2(C)C(CC=C(C3)OC)=C3CC[C@H]2[C@@H]2CCC(=O)[C@]21C KXRKCBBFKAQZRL-XEYPJELSSA-N 0.000 abstract 1
- GPVXNILSFVRKED-MWJCSLLCSA-N 3-[(8S,9S,13S,14S,17R)-3-methoxy-9,13-dimethyl-4,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-N,N-dimethylprop-2-yn-1-amine Chemical compound COC=1CC=2CC[C@H]3[C@@H]4CC[C@H]([C@@]4(C)CC[C@@]3(C=2CC=1)C)C#CCN(C)C GPVXNILSFVRKED-MWJCSLLCSA-N 0.000 abstract 1
- 125000002339 acetoacetyl group Chemical group O=C([*])C([H])([H])C(=O)C([H])([H])[H] 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3954670A | 1970-05-21 | 1970-05-21 | |
| US10961271A | 1971-01-25 | 1971-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1353162A true GB1353162A (en) | 1974-05-15 |
Family
ID=26716244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1523771A Expired GB1353162A (en) | 1970-05-21 | 1971-05-17 | 17alpha-propadienyl steroids |
Country Status (9)
-
1971
- 1971-05-12 CH CH697471A patent/CH548998A/xx not_active IP Right Cessation
- 1971-05-13 NL NL7106568A patent/NL7106568A/xx unknown
- 1971-05-17 GB GB1523771A patent/GB1353162A/en not_active Expired
- 1971-05-19 FI FI137971A patent/FI49296C/fi active
- 1971-05-19 SE SE653071A patent/SE373130B/xx unknown
- 1971-05-19 DE DE19712124951 patent/DE2124951A1/de active Pending
- 1971-05-19 FR FR7118217A patent/FR2100673B1/fr not_active Expired
- 1971-05-19 BE BE767431A patent/BE767431A/xx unknown
- 1971-05-19 DK DK244171A patent/DK127109B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK127109B (da) | 1973-09-24 |
| FR2100673A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-03-24 |
| BE767431A (fr) | 1971-11-19 |
| FI49296B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-01-31 |
| FI49296C (fi) | 1975-05-12 |
| FR2100673B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-30 |
| NL7106568A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-11-23 |
| SE373130B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-01-27 |
| CH548998A (de) | 1974-05-15 |
| DE2124951A1 (de) | 1971-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |