GB1347145A - 17alpha-propadienyl steroids - Google Patents
17alpha-propadienyl steroidsInfo
- Publication number
- GB1347145A GB1347145A GB993071A GB993071A GB1347145A GB 1347145 A GB1347145 A GB 1347145A GB 993071 A GB993071 A GB 993071A GB 993071 A GB993071 A GB 993071A GB 1347145 A GB1347145 A GB 1347145A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- prepared
- formula
- ring
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 hydride ion Chemical class 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- AFXJRVNZELTGDH-TZSPXAHUSA-N (8s,9s,13s,14s,17s)-17-ethynyl-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene Chemical compound C1C[C@]2(C)[C@H](C#C)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 AFXJRVNZELTGDH-TZSPXAHUSA-N 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 150000000670 8-azasteroids Chemical class 0.000 abstract 1
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001534 azasteroids Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- WMWSRIHFAVOHSW-UHFFFAOYSA-N lithium;ethane-1,2-diamine;ethyne Chemical compound [Li+].[C-]#C.NCCN WMWSRIHFAVOHSW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910001507 metal halide Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000002902 organometallic compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 238000005956 quaternization reaction Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 229960001124 trientine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3178270A | 1970-04-24 | 1970-04-24 | |
| US3954670A | 1970-05-21 | 1970-05-21 | |
| US5868270A | 1970-07-27 | 1970-07-27 | |
| US6992970A | 1970-09-04 | 1970-09-04 | |
| US10961271A | 1971-01-25 | 1971-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1347145A true GB1347145A (en) | 1974-02-27 |
Family
ID=27534357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB993071A Expired GB1347145A (en) | 1970-04-24 | 1971-04-19 | 17alpha-propadienyl steroids |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE766147A (enrdf_load_stackoverflow) |
| CH (1) | CH571537A5 (enrdf_load_stackoverflow) |
| DE (2) | DE2166715A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2092084B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1347145A (enrdf_load_stackoverflow) |
| NL (1) | NL153550B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118186A (en) * | 1982-03-01 | 1983-10-26 | Roussel Uclaf | 11-substituted steroid 4,9-dienes and 4-ene-9,10-epoxides |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803183A (en) * | 1973-01-10 | 1974-04-09 | Sandoz Ag | Preparation of 3-oxo-17alpha-propadienyl-substituted steroids |
| US5196571A (en) * | 1987-10-22 | 1993-03-23 | Basf Aktiengesellschaft | Preparation of unsaturated monoesters |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3385871A (en) * | 1965-12-15 | 1968-05-28 | Syntex Corp | Halogenated cyclopropyl and cyclopropenyl estratrienes and process for their preparation |
| SU402209A3 (enrdf_load_stackoverflow) * | 1968-11-25 | 1973-10-12 | ||
| IL34228A (en) * | 1969-04-18 | 1975-04-25 | Syntex Corp | The preparation of 17alpha-propadienyl steroids and novel 17alpha-(3-substituted propynyl)steroidal intermediates |
-
1971
- 1971-04-13 CH CH526471A patent/CH571537A5/xx not_active IP Right Cessation
- 1971-04-19 GB GB993071A patent/GB1347145A/en not_active Expired
- 1971-04-21 DE DE19712166715 patent/DE2166715A1/de active Pending
- 1971-04-21 DE DE19712119327 patent/DE2119327A1/de active Pending
- 1971-04-22 NL NL7105449A patent/NL153550B/xx unknown
- 1971-04-22 BE BE766147A patent/BE766147A/xx unknown
- 1971-04-22 FR FR7114359A patent/FR2092084B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118186A (en) * | 1982-03-01 | 1983-10-26 | Roussel Uclaf | 11-substituted steroid 4,9-dienes and 4-ene-9,10-epoxides |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2119327A1 (de) | 1971-11-04 |
| NL153550B (nl) | 1977-06-15 |
| FR2092084A1 (enrdf_load_stackoverflow) | 1972-01-21 |
| FR2092084B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| CH571537A5 (enrdf_load_stackoverflow) | 1976-01-15 |
| DE2166715A1 (de) | 1975-04-24 |
| BE766147A (fr) | 1971-10-22 |
| NL7105449A (enrdf_load_stackoverflow) | 1971-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |