GB1346972A - Antibiotic substance and the process for producing the same - Google Patents

Antibiotic substance and the process for producing the same

Info

Publication number
GB1346972A
GB1346972A GB4667372A GB1346972DA GB1346972A GB 1346972 A GB1346972 A GB 1346972A GB 4667372 A GB4667372 A GB 4667372A GB 1346972D A GB1346972D A GB 1346972DA GB 1346972 A GB1346972 A GB 1346972A
Authority
GB
United Kingdom
Prior art keywords
gatavalin
mol
butyl
broth
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4667372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kayaku Antibiotic Research Co Ltd
Original Assignee
Kayaku Antibiotic Research Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kayaku Antibiotic Research Co Ltd filed Critical Kayaku Antibiotic Research Co Ltd
Publication of GB1346972A publication Critical patent/GB1346972A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1346972 Gatavalin KAYAKU ANTIBIOTIC RESEARCH CO Ltd 10 Oct 1972 46673/72 Heading C2A The new antibiotic gatavalin having a molecular weight of about 2000, a melting point of 245‹ C.-248‹ C., an elementary analysis C 51À19%, H 8À19%, N 14À16%, and O 26À46% by difference, a positive reaction to biuret and tert.- butyl hypochlorite, a negative reaction to nin. hydrin, Fehling and Molish; containing 1 mol. glutamic acid, 1 mol. aspartic acid, 2 molalanine, 3 mol. valine and 3 mol. threonine; 23 having a specific rotation [α] +22À4‹(C:6À5% D in 50% methanol); bioautography on the agar plate seeding St. aureus, n-butanol : acetic acid: water (3 : 1 : 1 by volume) Rf is 0À9 to 0À95; showing end absorption in U.V. and having peaks at 3300, 2900, 1740, 1620, 1520, 1220 and 1150 cm. 1 in IR absorption spectrum (KBr), is prepared by cultivating a gatavalin-producing strain of Bacillus polymyxa var. colistinus KOYAMA, ATTCC No. 21830 in a nutrient medium under aerobic conditions and isolating and recovering the gatavalin from the cultured broth. Gatavalin is isolated and recovered from the cultured broth by acidifying at pH 2 to 5 the culture broth or an aqueous suspension of the cells separated from the culture broth, and thereafter heating, extracting the gatavalin with an organic solvent which is immiscible with water and capable of dissolving the gatavalin, e.g. butyl alcohol, isoamyl alcohol or chloroform, and then precipitating the gatavalin by the addition of a gatavalin-insoluble solvent, e.g. ether, ethyl acetate, butyl acetate or acetone.
GB4667372A 1972-10-10 1972-10-10 Antibiotic substance and the process for producing the same Expired GB1346972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4667372 1972-10-10

Publications (1)

Publication Number Publication Date
GB1346972A true GB1346972A (en) 1974-02-13

Family

ID=10442153

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4667372A Expired GB1346972A (en) 1972-10-10 1972-10-10 Antibiotic substance and the process for producing the same

Country Status (1)

Country Link
GB (1) GB1346972A (en)

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee