GB1342706A - N-6-disubstituted adenosine derivatives and the preparation thereof - Google Patents
N-6-disubstituted adenosine derivatives and the preparation thereofInfo
- Publication number
- GB1342706A GB1342706A GB4381372A GB4381372A GB1342706A GB 1342706 A GB1342706 A GB 1342706A GB 4381372 A GB4381372 A GB 4381372A GB 4381372 A GB4381372 A GB 4381372A GB 1342706 A GB1342706 A GB 1342706A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- cyclohexyl
- nebularin
- sept
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1342706 N<SP>6</SP>-Disubstituted-adenosine derivatives BOEHRINGER MANNHEIM GmbH 21 Sept 1972 [30 Sept 1971] 43813/72 Heading C2C Novel compounds (I) and their salts in which R 1 is straight or branched-chain alkyl and R 2 is straight- or branched-chain alkyl of at least 4 C atoms or a cycloalkyl cycloalkylalkyl or bicycloalkyl radical optionally substituted by an alkyl group are prepared by reaction of N<SP>6</SP> - (halogeno- or mercapto) - nebularin with an amine H-NR 1 R 2 . The ribose group of nebularin is protected preferably by acetyl groups, which are removed by basic hydrolysis. R 2 is cyclopropyl, cyclopentyl, cyclohexyl optionally substituted by methyl, cycloheptyl, cyclooctyl bicyclo[2,2,1]heptyl, cyclopropyl methyl, cyclopentyl methyl, cyclohexyl methyl, cyclohexyl-propyl-2-, butyl, pentyl or hexyl groups. Compounds (I) reduce the concentration of fatty acids, triglycerides and cholesterol in blood serum and form with a diluent or carrier a pharmaceutical composition which may be administered orally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712148838 DE2148838A1 (en) | 1971-09-30 | 1971-09-30 | NEW N (6) -DISUBSTITUTED ADENOSINE DERIVATIVES AND METHOD FOR MANUFACTURING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1342706A true GB1342706A (en) | 1974-01-03 |
Family
ID=5821069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4381372A Expired GB1342706A (en) | 1971-09-30 | 1972-09-21 | N-6-disubstituted adenosine derivatives and the preparation thereof |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5549593B2 (en) |
| AR (1) | AR193757A1 (en) |
| AT (1) | AT316764B (en) |
| AU (1) | AU462347B2 (en) |
| CA (1) | CA965086A (en) |
| CH (1) | CH564562A5 (en) |
| DD (1) | DD100717A5 (en) |
| DE (1) | DE2148838A1 (en) |
| ES (1) | ES406933A1 (en) |
| FR (1) | FR2154686B1 (en) |
| GB (1) | GB1342706A (en) |
| HU (1) | HU163674B (en) |
| NL (1) | NL7212929A (en) |
| ZA (1) | ZA726558B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8729994D0 (en) * | 1987-12-23 | 1988-02-03 | Glaxo Group Ltd | Chemical compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1219205A (en) * | 1954-05-06 | 1960-05-16 | American Cyanamid Co | Process for preparing ribofuranosylpurins |
-
1971
- 1971-09-30 DE DE19712148838 patent/DE2148838A1/en not_active Withdrawn
-
1972
- 1972-09-21 HU HUBO1394A patent/HU163674B/hu unknown
- 1972-09-21 GB GB4381372A patent/GB1342706A/en not_active Expired
- 1972-09-22 AR AR244242A patent/AR193757A1/en active
- 1972-09-22 DD DD165804A patent/DD100717A5/xx unknown
- 1972-09-22 ES ES406933A patent/ES406933A1/en not_active Expired
- 1972-09-25 NL NL7212929A patent/NL7212929A/xx not_active Application Discontinuation
- 1972-09-26 ZA ZA726558A patent/ZA726558B/en unknown
- 1972-09-27 CH CH1416672A patent/CH564562A5/xx not_active IP Right Cessation
- 1972-09-28 AU AU47232/72A patent/AU462347B2/en not_active Expired
- 1972-09-28 FR FR7234353A patent/FR2154686B1/fr not_active Expired
- 1972-09-29 AT AT840772A patent/AT316764B/en not_active IP Right Cessation
- 1972-09-29 CA CA152,966A patent/CA965086A/en not_active Expired
- 1972-09-30 JP JP9854972A patent/JPS5549593B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES406933A1 (en) | 1975-10-01 |
| AT316764B (en) | 1974-07-25 |
| CH564562A5 (en) | 1975-07-31 |
| NL7212929A (en) | 1973-04-03 |
| ZA726558B (en) | 1973-07-25 |
| JPS5549593B2 (en) | 1980-12-12 |
| AU4723272A (en) | 1974-04-04 |
| FR2154686B1 (en) | 1975-10-31 |
| DE2148838A1 (en) | 1973-04-05 |
| CA965086A (en) | 1975-03-25 |
| DD100717A5 (en) | 1973-10-05 |
| HU163674B (en) | 1973-10-27 |
| FR2154686A1 (en) | 1973-05-11 |
| AR193757A1 (en) | 1973-05-22 |
| JPS4861496A (en) | 1973-08-28 |
| AU462347B2 (en) | 1975-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |