GB1342391A - Preparation of thymocyte antigens and of anti-thymocytary serums and gammaglobulins - Google Patents
Preparation of thymocyte antigens and of anti-thymocytary serums and gammaglobulinsInfo
- Publication number
- GB1342391A GB1342391A GB427671A GB1342391DA GB1342391A GB 1342391 A GB1342391 A GB 1342391A GB 427671 A GB427671 A GB 427671A GB 1342391D A GB1342391D A GB 1342391DA GB 1342391 A GB1342391 A GB 1342391A
- Authority
- GB
- United Kingdom
- Prior art keywords
- animal
- serum
- suspension
- thymocytary
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
Abstract
1342391 Thymocytary antigens and antiserum ALBERT ROLLAND SA 2 Feb 1972 [9 Feb 1971] 4276/71 Heading ASB Animal thymocytary antigens are prepared and preserved by (a) forming a cellular suspension of thymocytes from an animal thymus or from the Fabricius bursa of a bird, (b) filtering the suspension on a series of increasingly fine screens or on a number of layers of gauze, (c) centrifuging the filtrate, (d) resuspending the sediment in buffered physiological solution, (e) destroying the erythrocytes, (f) washing the sediment with buffered physiological solution with centrifuging, (g) checking the cell suspension so obtained for the absence of cellular contaminants, (h) freezing and preserving the suspension at -20 to -40C and (i) when required for use, thawing the suspension and dissociating it by agitation in the presence of spherical balls. An antithymocytary serum specific to one animal species may be prepared by (a) injecting the antigen product of this process into an animal of a different species, (b) taking serum from the animal during immunization and testing it for soluble circulating antigent-antibody complexes, (c) harvesting serum from the immunized animal and (d) purifying the serum by adsorption on a polymer prepared from glutaraldehyde and protein derived from the liver and serum of the animal from which the antigen was obtained or another animal of the same species.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB427671 | 1971-02-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1342391A true GB1342391A (en) | 1974-01-03 |
Family
ID=9774071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB427671A Expired GB1342391A (en) | 1971-02-09 | 1971-02-09 | Preparation of thymocyte antigens and of anti-thymocytary serums and gammaglobulins |
Country Status (18)
| Country | Link |
|---|---|
| AT (1) | AT316743B (en) |
| AU (1) | AU460448B2 (en) |
| BE (1) | BE778754A (en) |
| CA (1) | CA955849A (en) |
| CH (1) | CH538866A (en) |
| DE (1) | DE2205897C3 (en) |
| DK (1) | DK132104C (en) |
| ES (1) | ES399465A1 (en) |
| FI (1) | FI50203C (en) |
| FR (1) | FR2124298B1 (en) |
| GB (1) | GB1342391A (en) |
| IL (1) | IL38704A (en) |
| LU (1) | LU64739A1 (en) |
| NL (1) | NL7201683A (en) |
| NO (1) | NO137308C (en) |
| OA (1) | OA03962A (en) |
| RO (1) | RO61514A (en) |
| ZA (1) | ZA72825B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006064373A2 (en) * | 2004-12-16 | 2006-06-22 | Genzyme Polyclonals S.A.S. | Methods of purifying immunologlobulins |
-
1971
- 1971-02-09 GB GB427671A patent/GB1342391A/en not_active Expired
-
1972
- 1972-01-28 CH CH124472A patent/CH538866A/en not_active IP Right Cessation
- 1972-01-28 FR FR7202948A patent/FR2124298B1/fr not_active Expired
- 1972-01-31 BE BE778754A patent/BE778754A/en not_active IP Right Cessation
- 1972-02-03 ES ES399465A patent/ES399465A1/en not_active Expired
- 1972-02-04 CA CA134,005A patent/CA955849A/en not_active Expired
- 1972-02-04 RO RO69679A patent/RO61514A/ro unknown
- 1972-02-07 DK DK52772*#A patent/DK132104C/en not_active IP Right Cessation
- 1972-02-07 LU LU64739D patent/LU64739A1/xx unknown
- 1972-02-07 NO NO311/72A patent/NO137308C/en unknown
- 1972-02-07 IL IL38704A patent/IL38704A/en unknown
- 1972-02-07 AU AU38760/72A patent/AU460448B2/en not_active Expired
- 1972-02-08 FI FI720344A patent/FI50203C/en active
- 1972-02-08 DE DE2205897A patent/DE2205897C3/en not_active Expired
- 1972-02-08 ZA ZA720825A patent/ZA72825B/en unknown
- 1972-02-08 OA OA54493A patent/OA03962A/en unknown
- 1972-02-09 AT AT103972A patent/AT316743B/en not_active IP Right Cessation
- 1972-02-09 NL NL7201683A patent/NL7201683A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006064373A2 (en) * | 2004-12-16 | 2006-06-22 | Genzyme Polyclonals S.A.S. | Methods of purifying immunologlobulins |
| WO2006064373A3 (en) * | 2004-12-16 | 2006-09-08 | Genzyme Polyclonals S A S | Methods of purifying immunologlobulins |
Also Published As
| Publication number | Publication date |
|---|---|
| AU460448B2 (en) | 1975-04-09 |
| IL38704A0 (en) | 1972-04-27 |
| ZA72825B (en) | 1972-10-25 |
| NL7201683A (en) | 1972-08-11 |
| ES399465A1 (en) | 1975-07-01 |
| AT316743B (en) | 1974-07-25 |
| RO61514A (en) | 1976-12-15 |
| CH538866A (en) | 1973-07-15 |
| IL38704A (en) | 1974-12-31 |
| DE2205897A1 (en) | 1972-08-24 |
| DE2205897C3 (en) | 1980-05-22 |
| BE778754A (en) | 1972-05-16 |
| OA03962A (en) | 1979-08-31 |
| NO137308B (en) | 1977-10-31 |
| DK132104B (en) | 1975-10-27 |
| FR2124298B1 (en) | 1975-12-26 |
| DK132104C (en) | 1976-03-22 |
| AU3876072A (en) | 1973-08-09 |
| CA955849A (en) | 1974-10-08 |
| FI50203C (en) | 1976-01-12 |
| FI50203B (en) | 1975-09-30 |
| FR2124298A1 (en) | 1972-09-22 |
| LU64739A1 (en) | 1972-07-03 |
| DE2205897B2 (en) | 1979-08-30 |
| NO137308C (en) | 1978-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 435 | Patent endorsed 'licences of right' on the date specified (sect. 35/1949) | ||
| PCNP | Patent ceased through non-payment of renewal fee |