GB1340529A - Method of producing an indole derivative - Google Patents

Method of producing an indole derivative

Info

Publication number
GB1340529A
GB1340529A GB1340529DA GB1340529A GB 1340529 A GB1340529 A GB 1340529A GB 1340529D A GB1340529D A GB 1340529DA GB 1340529 A GB1340529 A GB 1340529A
Authority
GB
United Kingdom
Prior art keywords
keto
tetrahydro
methyl
producing
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
V N I KHIM FARMATSEVTICHESKY I
Original Assignee
V N I KHIM FARMATSEVTICHESKY I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by V N I KHIM FARMATSEVTICHESKY I filed Critical V N I KHIM FARMATSEVTICHESKY I
Publication of GB1340529A publication Critical patent/GB1340529A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Abstract

1340529 Process for 1,10-trimethylene-8- methyl - 1,2,3,4 - tetrahydropyrazino[1,2- a] indole and its hydrochloride VSESOJUZNY NAUCHNO-ISSLEDOVATESKY KHIMIKOFAKMATSEVTICHESKY INSTITUT IMENI SERGO ORDZHONIKIDZE 27 March 1971 11461/73 Divided out of 1340528 Heading C2C The invention comprises a method of producing 1,10 - trimethylene - 8 - methyl - 1,2,3,4- tetrahydropyrazino - [1,2 - a] - indole hydrochloride by reacting 1-keto-1,2,3,4-tetrahydro- 6-methylcarbazole with a base to form a derivative of 1-keto-1,2,3,4-tetrahydro-6-methylcarbazole, alkylating the derivative with chloroacetonitrile in the presence of an organic solvent to form 1-keto-1,2,3,4-tetrahydro-6-methyl-9- cyanmethyl-carbazole, effecting a reductive cyclization of the cyanmethylcarbazole with hydrogen in the presence of a hydrogenation catalyst and an organic solvent and at a pressure of 30 to 70 atmospheres and a temperature within the range from 30‹ to 60‹ C., and treating 'the resultant cyclized compound with hydrogen chloride.
GB1340529D 1971-03-27 1971-03-27 Method of producing an indole derivative Expired GB1340529A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1146173 1971-03-27

Publications (1)

Publication Number Publication Date
GB1340529A true GB1340529A (en) 1973-12-12

Family

ID=9986680

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1340529D Expired GB1340529A (en) 1971-03-27 1971-03-27 Method of producing an indole derivative

Country Status (1)

Country Link
GB (1) GB1340529A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4697016A (en) * 1984-10-26 1987-09-29 Ciba-Geigy Corporation Intermediates for the preparation of a carboxylic acid
WO1991007968A1 (en) * 1989-11-27 1991-06-13 Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Institut Imeni Sergo Ordzhonikidze (Vnikhfi) Hydrochloride 2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1h-pyrazino (3,2,1-j,k)carbazol, method of obtaining it and a pharmaceutical preparation of antidepressive action based on it

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4697016A (en) * 1984-10-26 1987-09-29 Ciba-Geigy Corporation Intermediates for the preparation of a carboxylic acid
WO1991007968A1 (en) * 1989-11-27 1991-06-13 Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Institut Imeni Sergo Ordzhonikidze (Vnikhfi) Hydrochloride 2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1h-pyrazino (3,2,1-j,k)carbazol, method of obtaining it and a pharmaceutical preparation of antidepressive action based on it

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years