GB1331933A - Antiviral ribonucleic acids - Google Patents

Antiviral ribonucleic acids

Info

Publication number
GB1331933A
GB1331933A GB1331933DA GB1331933A GB 1331933 A GB1331933 A GB 1331933A GB 1331933D A GB1331933D A GB 1331933DA GB 1331933 A GB1331933 A GB 1331933A
Authority
GB
United Kingdom
Prior art keywords
particles
virus
antiviral
ribonucleic acids
ribonucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of GB1331933A publication Critical patent/GB1331933A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24123—Virus like particles [VLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1331933 Antiviral ribonucleic acids GLAXO LABORATORIES Ltd 13 Nov 1970 [17 Nov 1969] 56169/69 Heading C3H [Also in Division A5] A process for the production of one or both of the antiviral ribonucleic acids I and II from P. chrysogenum having the characteristics: ribonucleic acid IS 20,w (as herein defined) = 11À7 to 12À3 Base analysis: Guanine 25À0% Œ 1À0 Adenine 25À0% Œ 1À0. Cytosine 25À0% Œ 1À0. Uracil 25À0% Œ 1À0. Ribonucleic acid IIS 20,w (as herein defined) = 6-7 to 7À3 Base analysis: Guanine 18À0% Œ 1À0. Adenine 32À0% Œ 1À0. Cytosine 18À0% Œ 1À0. Uracil 32À0% Œ 1À0. Said process comprising the steps of (a) culturing a strain of P. chrysogenum, preferably ATCC 10,002, 10,003, 11,707, 13,799 or a mutant thereof in or on a nutrient medium therefor whereby virus-like particles as herein defined proliferate therein; (b) rupture of the cells of the micro-organism without removing the coating of the virus-like particles, and then removal of cell debris from the virus-like particles; (c) partial or complete separation of the viruslike particles from free nucleic acids and other dissolved materials; (d) decoating the virus-like particles; and (e) fractionation whereby the desired antiviral double-stranded ribonucleic acids I and II are isolated and unwanted material is rejected. Pharmaceutical compositions may be prepared from the products.
GB1331933D 1969-11-17 1969-11-17 Antiviral ribonucleic acids Expired GB1331933A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5616969 1969-11-17

Publications (1)

Publication Number Publication Date
GB1331933A true GB1331933A (en) 1973-09-26

Family

ID=10475915

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1331933D Expired GB1331933A (en) 1969-11-17 1969-11-17 Antiviral ribonucleic acids

Country Status (5)

Country Link
BE (1) BE758977A (en)
DE (1) DE2056294A1 (en)
FR (1) FR2073366B1 (en)
GB (1) GB1331933A (en)
NL (1) NL7016747A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063657A1 (en) * 1981-04-29 1982-11-03 Merck & Co. Inc. Topical application of interferon inducers
US4908318A (en) * 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US5057426A (en) * 1986-11-22 1991-10-15 Diagen Institut Fur Molekular-Biologische, Diagnostik Gmbh Method for separating long-chain nucleic acids

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039325A1 (en) * 1979-10-19 1981-11-11 ROMANO, Amalia Medicine for the treatment of viral infections of the eye and other organs
FR2550707B1 (en) * 1983-08-17 1986-02-28 Lipha IMMUNOMODULATOR OF BIOLOGICAL MEDICINE AND PROCESS FOR PREPARING THE SAME
DE3833925A1 (en) * 1988-03-11 1989-09-21 Inst Angewandte Biotechnologie PROCESS AND MANUFACTURE OF VIRUS AND VIRAL ANTIGEN AND DEVICE THEREFOR

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063657A1 (en) * 1981-04-29 1982-11-03 Merck & Co. Inc. Topical application of interferon inducers
US5057426A (en) * 1986-11-22 1991-10-15 Diagen Institut Fur Molekular-Biologische, Diagnostik Gmbh Method for separating long-chain nucleic acids
US4908318A (en) * 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods

Also Published As

Publication number Publication date
BE758977A (en) 1971-05-17
FR2073366A1 (en) 1971-10-01
FR2073366B1 (en) 1975-08-01
DE2056294A1 (en) 1971-07-15
NL7016747A (en) 1971-05-19

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees