GB1325912A - Streptokinase compositions - Google Patents

Streptokinase compositions

Info

Publication number
GB1325912A
GB1325912A GB5356670A GB5356670A GB1325912A GB 1325912 A GB1325912 A GB 1325912A GB 5356670 A GB5356670 A GB 5356670A GB 5356670 A GB5356670 A GB 5356670A GB 1325912 A GB1325912 A GB 1325912A
Authority
GB
United Kingdom
Prior art keywords
streptokinase
dextran
carbohydrates
compositions
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5356670A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Publication of GB1325912A publication Critical patent/GB1325912A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

1325912 Streptokinase - carbohydrate polymer compositions BAXTER LABORATORIES Ino 11 Nov 1970 [2 Dec 1969] 53566/70 Heading C3H A streptokinase composition comprises one part by weight of streptokinase chemically bonded to from one to five hundred parts by weight of a support of a polymer comprising carbohydrate units for example polysaccharides such as cellulose, dextran, starch or dextrins, preferably having a molecular weight of 70,000 to 500,000, polymerized derivatives of carbohydrates, alkali metal containing derivatives of carbohydrates, copolymers of sucrose and epichlorohydrin, carbohydrates etherified with aminoalkyl groups such as aminoethyl and carboxyl containing derivatives for example carboxyethylcellulose, carboxymethyldextran and carboxypropyldextran. In the preferred compositions the streptokinase is bonded to the support via the groups wherein R is the support medium having a bond on an oxygen atom connected to the moiety, R<SP>1</SP> is streptokinase, n is a positive integer and X is a monovalent hydrocarbon radical having no more than 4 carbon atoms, a hydrogen or halogen atom or a further R or R<SP>1</SP> group. The compositions are obtained by reacting the streptokinase with carbohydrate azides, triazine derivatives or by the use of carbodiimides. In the examples "dextran azide" is prepared by diazotization of the hydrazide obtained by reaction of hydrazine and carbomethoxy dextran, or with carboxyethyl dextran. A copolymer of sucrose and epichlorohydrin is converted into a streptokinase reactive compound with cyanuric chloride or a substance of the formula in which X is Br, Me, H, Pri, n-Bu, I, or allyl.
GB5356670A 1969-12-02 1970-11-11 Streptokinase compositions Expired GB1325912A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88163269A 1969-12-02 1969-12-02

Publications (1)

Publication Number Publication Date
GB1325912A true GB1325912A (en) 1973-08-08

Family

ID=25378866

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5356670A Expired GB1325912A (en) 1969-12-02 1970-11-11 Streptokinase compositions

Country Status (11)

Country Link
US (1) US3639213A (en)
BE (1) BE758425A (en)
CA (1) CA976101A (en)
DE (1) DE2059165A1 (en)
DK (1) DK131471B (en)
FR (1) FR2073443B1 (en)
GB (1) GB1325912A (en)
IL (1) IL35545A (en)
IT (1) IT1050704B (en)
NL (1) NL7017625A (en)
ZA (1) ZA707355B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140275432A1 (en) * 2013-03-15 2014-09-18 Lawrence Livermore National Security, Llc Methods for the selective sequestration of alkyne-presenting molecules and related compositions and methods

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4167446A (en) * 1973-03-15 1979-09-11 Bayer Aktiengesellschaft Water soluble carrier-bound penicillinacylase
US3865615A (en) * 1973-05-07 1975-02-11 Air Prod & Chem Non-thrombogenic plastics
GB1479268A (en) * 1973-07-05 1977-07-13 Beecham Group Ltd Pharmaceutical compositions
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4273873A (en) * 1977-10-25 1981-06-16 Unitika Ltd. Preparation of antithrombogenic polymeric materials
US4305926A (en) * 1979-09-13 1981-12-15 Johannes Everse Immobilization of Streptokinase
DE3033029A1 (en) * 1979-09-28 1981-04-23 Vsesojuznyj kardiologi&ccaron;eskij nau&ccaron;nyj centr Akademii medicinskich Nauk SSSR,, Moskva Thrombolytic urokinase water-soluble deriv. - obtd. by reaction of urokinase with aldehyde dextran
IT1209419B (en) * 1980-07-01 1989-07-16 Texcontor Ets COMPOUNDS WITH NON-SIMILAR MUCOLITICAL ACTIVITIES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT INCLUDE THEM AS AN ACTIVE INGREDIENT.
JPS5823847B2 (en) * 1981-02-06 1983-05-18 株式会社 林原生物化学研究所 Method for producing anti-human protein antibodies
CA2047730A1 (en) * 1989-02-24 1990-08-25 Carl W. Gilbert Immobilized cytokines
US5230891A (en) * 1990-08-20 1993-07-27 Kanebo Limited Modified protease, method of producing the same and cosmetic products containing the modified protease
US5133968A (en) * 1990-08-20 1992-07-28 Kanebo, Ltd. Modified protease, method of producing the same and cosmetic products containing the modified protease
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
AU4104093A (en) * 1992-04-20 1993-11-18 Rufeld, Inc. Method and compositions for treatment of pyonecrotic processes
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
BRPI0913397B8 (en) * 2008-06-04 2021-05-25 Grifols Therapeutics Inc method for preparing plasmin
US9206410B2 (en) 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
CN104758945B (en) * 2015-02-26 2018-10-16 宁波大学 A kind of the thrombolytic drug targeted nano gel and its preparation method and use of pH responses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL287978A (en) * 1962-10-17 1900-01-01
US3255094A (en) * 1963-01-10 1966-06-07 Baxter Laboratories Inc Method for purification of streptokinase
GB1108533A (en) * 1965-03-20 1968-04-03 Kyowa Hakko Kogyo Kk Water-insoluble enzymes
US3824150A (en) * 1967-07-14 1974-07-16 Nat Res Dev Enzyme bound to polymeric sheet with a triazine bridging group

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140275432A1 (en) * 2013-03-15 2014-09-18 Lawrence Livermore National Security, Llc Methods for the selective sequestration of alkyne-presenting molecules and related compositions and methods
US9791463B2 (en) 2013-03-15 2017-10-17 Lawrence Livermore National Security, Llc Methods for the selective detection of alkyne-presenting molecules and related compositions and systems
US10082514B2 (en) 2013-03-15 2018-09-25 Lawrence Livermore National Security, Llc Methods for the selective detection of alkyne-presenting molecules and related compositions and systems
US10088491B2 (en) * 2013-03-15 2018-10-02 Lawrence Livermore National Security, Llc Methods for the selective sequestration of alkyne-presenting molecules and related compositions and methods

Also Published As

Publication number Publication date
DK131471C (en) 1975-12-08
IL35545A0 (en) 1970-12-24
CA976101A (en) 1975-10-14
FR2073443A1 (en) 1971-10-01
US3639213A (en) 1972-02-01
NL7017625A (en) 1971-06-04
IL35545A (en) 1974-06-30
DK131471B (en) 1975-07-21
DE2059165A1 (en) 1971-06-09
FR2073443B1 (en) 1975-04-18
ZA707355B (en) 1971-07-28
IT1050704B (en) 1981-03-20
BE758425A (en) 1971-04-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees