GB1325005A - Process for preparing 9alpha-fluoro-11-oxosteroids - Google Patents
Process for preparing 9alpha-fluoro-11-oxosteroidsInfo
- Publication number
- GB1325005A GB1325005A GB2943770A GB1325005DA GB1325005A GB 1325005 A GB1325005 A GB 1325005A GB 2943770 A GB2943770 A GB 2943770A GB 1325005D A GB1325005D A GB 1325005DA GB 1325005 A GB1325005 A GB 1325005A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluoro
- group
- oxo
- oxosteroids
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000005977 Ethylene Substances 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- XHFXMNZYIKFCPN-UHFFFAOYSA-N perchloryl fluoride Chemical compound FCl(=O)(=O)=O XHFXMNZYIKFCPN-UHFFFAOYSA-N 0.000 abstract 2
- BHDHELFREODRJK-XRYUJSLGSA-N (8s,9r,10s,13s,14s,17r)-9-fluoro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,12,14,15,16-octahydro-1h-cyclopenta[a]phenanthrene-3,11-dione Chemical compound O=C1CC[C@]2(C)[C@@]3(F)C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 BHDHELFREODRJK-XRYUJSLGSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000005837 enolization reaction Methods 0.000 abstract 1
- 238000003682 fluorination reaction Methods 0.000 abstract 1
- 125000005597 hydrazone group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229950000801 hydroxyprogesterone caproate Drugs 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
- 125000005106 triarylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2943770 | 1970-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1325005A true GB1325005A (en) | 1973-08-01 |
Family
ID=10291548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2943770A Expired GB1325005A (en) | 1970-06-17 | 1970-06-17 | Process for preparing 9alpha-fluoro-11-oxosteroids |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3728337A (enExample) |
| CA (1) | CA929155A (enExample) |
| CH (1) | CH576998A5 (enExample) |
| DE (1) | DE2129941A1 (enExample) |
| FR (1) | FR2096326A5 (enExample) |
| GB (1) | GB1325005A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1532232A (en) * | 1975-05-22 | 1978-11-15 | Res Inst For Med & Chem Inc | Electrophilic fluorination of steroids |
-
1970
- 1970-06-17 GB GB2943770A patent/GB1325005A/en not_active Expired
-
1971
- 1971-06-09 US US00150842A patent/US3728337A/en not_active Expired - Lifetime
- 1971-06-14 CH CH865671A patent/CH576998A5/xx not_active IP Right Cessation
- 1971-06-15 FR FR7121623A patent/FR2096326A5/fr not_active Expired
- 1971-06-16 DE DE19712129941 patent/DE2129941A1/de active Pending
- 1971-06-16 CA CA115782A patent/CA929155A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3728337A (en) | 1973-04-17 |
| FR2096326A5 (enExample) | 1972-02-11 |
| DE2129941A1 (de) | 1971-12-30 |
| CH576998A5 (enExample) | 1976-06-30 |
| CA929155A (en) | 1973-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |