GB1324968A - Process for the preparation of 15,16,-diacetyl-digoxin - Google Patents
Process for the preparation of 15,16,-diacetyl-digoxinInfo
- Publication number
- GB1324968A GB1324968A GB979572A GB979572A GB1324968A GB 1324968 A GB1324968 A GB 1324968A GB 979572 A GB979572 A GB 979572A GB 979572 A GB979572 A GB 979572A GB 1324968 A GB1324968 A GB 1324968A
- Authority
- GB
- United Kingdom
- Prior art keywords
- digoxin
- diacetyl
- preparation
- diacetate
- march
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 abstract 3
- 229960005156 digoxin Drugs 0.000 abstract 3
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 abstract 3
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 abstract 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 abstract 1
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- -1 heterocyclic tertiary amine Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712110646 DE2110646A1 (de) | 1971-03-05 | 1971-03-05 | Verfahren zur Herstellung von 15',16'-Diacetyldigixin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1324968A true GB1324968A (en) | 1973-07-25 |
Family
ID=5800658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB979572A Expired GB1324968A (en) | 1971-03-05 | 1972-03-02 | Process for the preparation of 15,16,-diacetyl-digoxin |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT312817B (enrdf_load_stackoverflow) |
| CH (1) | CH561740A5 (enrdf_load_stackoverflow) |
| DD (1) | DD95563A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2110646A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2158170B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1324968A (enrdf_load_stackoverflow) |
| HU (1) | HU162744B (enrdf_load_stackoverflow) |
-
1971
- 1971-03-05 DE DE19712110646 patent/DE2110646A1/de active Pending
-
1972
- 1972-03-01 FR FR7207007A patent/FR2158170B1/fr not_active Expired
- 1972-03-02 DD DD16126572A patent/DD95563A5/xx unknown
- 1972-03-02 GB GB979572A patent/GB1324968A/en not_active Expired
- 1972-03-03 CH CH313772A patent/CH561740A5/xx not_active IP Right Cessation
- 1972-03-03 AT AT181472A patent/AT312817B/de not_active IP Right Cessation
- 1972-03-03 HU HUBO001354 patent/HU162744B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT312817B (de) | 1974-01-25 |
| CH561740A5 (enrdf_load_stackoverflow) | 1975-05-15 |
| HU162744B (enrdf_load_stackoverflow) | 1973-04-28 |
| DD95563A5 (enrdf_load_stackoverflow) | 1973-02-12 |
| DE2110646A1 (de) | 1972-09-07 |
| FR2158170A1 (enrdf_load_stackoverflow) | 1973-06-15 |
| FR2158170B1 (enrdf_load_stackoverflow) | 1976-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA943129A (en) | Process for the production of n-(1,1,1-trisubstituted)-methylazoles | |
| CS179950B2 (en) | Method for production of novel d-homopregn-4-ene 3,20-diones | |
| CA1009649A (en) | PROCESS FOR PURIFYING .alpha.-L-ASPARTYL-L-PHENYLALANINE LOWER ALKYL ESTERS | |
| CA945023A (en) | Method of controlling ultrafines from reactive form coke | |
| GB1324968A (en) | Process for the preparation of 15,16,-diacetyl-digoxin | |
| CA954685A (en) | Process for the improvement of the constitution of soils | |
| YU216679A (en) | Process for the enzymatic synthesis of semisynthetic penicillins | |
| CA929121A (en) | Non-ramified culture growing apparatus | |
| IT972145B (it) | Metodo per produrre bata amilasi mediante fermentazione batterica | |
| CA994328A (en) | METHOD OF PRODUCING .alpha.-L-ASPARTYL-L-PHENYLALANINE ALKYL ESTERS | |
| CA1034521A (en) | PROCESS FOR THE PREPARATION OF 17-ACYL ESTERS OF 17.alpha.,21-DIHYDROXYSTEROIDS OF THE PREGNANE SERIES | |
| BE837156A (fr) | Dispositif pour la culture de microorganismes | |
| GB1403567A (en) | Process for the manufacture of pregnane derivatives | |
| CA944135A (en) | Apparatus for the manufacture of novel 1,2-dihydroquinolines | |
| ZA734698B (en) | Esters of beta-(3,4-dialkanoyloxyphenyl)-l-alanines | |
| AU473017B2 (en) | Process for the manufacture of pregnane derivatives | |
| CA962282A (en) | Process for the production of 3,4-unsaturated nitriles | |
| ES425358A1 (es) | Un procedimiento para preparar nuevos intermediarios de prostaglandinas. | |
| CA976155A (en) | PROCESS FOR PREPARING 17-ESTERS OF 6.alpha.,9.alpha.-DIFLUORO-21-DESOXYPREDNISOLONE | |
| CA873848A (en) | Process for the recovery of micro-organisms | |
| CA833000A (en) | Process for increasing the yield of tylosin produced by fermentation of microorganisms | |
| AU485796B2 (en) | Throat-gas cleaning plant for pressure blast furnaces | |
| CA989342A (en) | 2-hydroxy-3-methoxypropyl-n-(7 or 8-chloro-4-quinolinyl)-anthranilates from basidiomycete | |
| CA966506A (en) | Process for the isomerization of 5-vinylbicyclo(2.2.1)hept-2-enes | |
| CA982508A (en) | Recovery of bacteria from fermentation liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |