GB1319007A - Nonthrombogenic plastics - Google Patents
Nonthrombogenic plasticsInfo
- Publication number
- GB1319007A GB1319007A GB1319007DA GB1319007A GB 1319007 A GB1319007 A GB 1319007A GB 1319007D A GB1319007D A GB 1319007DA GB 1319007 A GB1319007 A GB 1319007A
- Authority
- GB
- United Kingdom
- Prior art keywords
- heparin
- solution
- plastics
- coupling agent
- aminosilane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004033 plastic Substances 0.000 title abstract 4
- 229920003023 plastic Polymers 0.000 title abstract 4
- 230000001453 nonthrombogenic effect Effects 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 7
- 229960002897 heparin Drugs 0.000 abstract 6
- 229920000669 heparin Polymers 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 6
- 239000007822 coupling agent Substances 0.000 abstract 5
- -1 polyethylene Polymers 0.000 abstract 5
- 239000000243 solution Substances 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- FZHAPNGMFPVSLP-UHFFFAOYSA-N silanamine Chemical compound [SiH3]N FZHAPNGMFPVSLP-UHFFFAOYSA-N 0.000 abstract 4
- 230000008961 swelling Effects 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002033 PVDF binder Substances 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229920002367 Polyisobutene Polymers 0.000 abstract 1
- 239000004743 Polypropylene Substances 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000003929 acidic solution Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- ZRSKSQHEOZFGLJ-UHFFFAOYSA-N ammonium adipate Chemical compound [NH4+].[NH4+].[O-]C(=O)CCCCC([O-])=O ZRSKSQHEOZFGLJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 abstract 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000007654 immersion Methods 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 abstract 1
- 229920002239 polyacrylonitrile Polymers 0.000 abstract 1
- 229920000120 polyethyl acrylate Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000004926 polymethyl methacrylate Substances 0.000 abstract 1
- 229920001155 polypropylene Polymers 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 abstract 1
- 239000004810 polytetrafluoroethylene Substances 0.000 abstract 1
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 1
- 239000011118 polyvinyl acetate Substances 0.000 abstract 1
- 239000004800 polyvinyl chloride Substances 0.000 abstract 1
- 229920000915 polyvinyl chloride Polymers 0.000 abstract 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000005588 protonation Effects 0.000 abstract 1
- 230000011514 reflex Effects 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 abstract 1
- 229920001169 thermoplastic Polymers 0.000 abstract 1
- 239000012815 thermoplastic material Substances 0.000 abstract 1
- 239000004416 thermosoftening plastic Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0023—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a quaternized group or a protonated amine group of the substrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Laminated Bodies (AREA)
Abstract
1319007 Heparin coated articles CORNING GLASS WORKS 3 Nov 1971 [4 Nov 1970] 51041/71 Heading B2E A method of bonding heparin to a thermoplastic material comprises impregnating the surface of the material with an amino coupling agent by subjecting the refluxing solution of aminosilane in a plastics swelling agent to swell the surface of the material and bond the aminosilane coupling agent to the material, drying to remove the plastics swelling agent, protonating by immersing the material in an aqueous acid saline solution and immersing the material in an aqueous acidic solution of a heparin salt for a time sufficient to bond the heparin to the protonated aminosilane coupling agent. Suitable thermoplastics materials are polyethylene, polypropylene, polystyrene, polyisobutylene, polyvinyl chloride, polyvinylidene fluoride, polyvinyl acetate, polyacrylonitrile, polyethyl acrylate, polymethyl methacrylate, polyethylene glycol terephthalate, polytetrafluoroethylene, polyhexamethylene diamine adipate, cellulose actate, ethyl cellulose, polyformaldhehyde and copolymers of these. Suitable swelling agents are toluene, benzene and hexane. Preferred aminosilane coupling agents have a chemical structure in which the central silicon atom has attached thereto at least one hydrolyzable alkyloxy group or halogen atom. Treatment with the plastics with the swelling agent may be effected for an extended period. Preferably coupling agent used in a 10% solution at a reflex time 16 to 64 hours. Protonating solution preferably contains at least 0.1 mol of an alkali metal or ammonium halide at a pH of 1-4. Protonation may be carried out by immersion for 5-20 hours. The heparin may be applied as the sodium, lithium, barium or ammonium salt. The heparin solution preferably contains at least 1 milligram of heparin per milligram of solution and should be at a pH of between 3 and 4. The method may be applied to prosthetic devices.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8678970A | 1970-11-04 | 1970-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1319007A true GB1319007A (en) | 1973-05-31 |
Family
ID=22200928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1319007D Expired GB1319007A (en) | 1970-11-04 | 1971-11-03 | Nonthrombogenic plastics |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE774852A (en) |
| CA (1) | CA960584A (en) |
| DE (1) | DE2154542A1 (en) |
| FR (1) | FR2113524A5 (en) |
| GB (1) | GB1319007A (en) |
| NL (1) | NL7115133A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588624A (en) * | 1982-05-14 | 1986-05-13 | Astra Meditec Ab | Articles exhibiting a biocompatible surface layer |
| US5541167A (en) * | 1991-05-31 | 1996-07-30 | Baxter International Inc. | Thromboresistant coating for defoaming applications |
| US5607475A (en) * | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
| US5679659A (en) * | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
| US5767108A (en) * | 1995-08-22 | 1998-06-16 | Medtronic, Inc. | Method for making improved heparinized biomaterials |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820302A (en) * | 1982-04-22 | 1989-04-11 | Sterling Drug Inc. | Bio compatible and blood compatible materials and methods |
| GB8401534D0 (en) * | 1984-01-20 | 1984-02-22 | Royal Free Hosp School Med | Biocompatible surfaces |
-
1971
- 1971-10-26 CA CA126,088A patent/CA960584A/en not_active Expired
- 1971-11-03 FR FR7139397A patent/FR2113524A5/fr not_active Expired
- 1971-11-03 DE DE19712154542 patent/DE2154542A1/en active Pending
- 1971-11-03 GB GB1319007D patent/GB1319007A/en not_active Expired
- 1971-11-03 NL NL7115133A patent/NL7115133A/xx unknown
- 1971-11-03 BE BE774852A patent/BE774852A/en unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588624A (en) * | 1982-05-14 | 1986-05-13 | Astra Meditec Ab | Articles exhibiting a biocompatible surface layer |
| US4673584A (en) * | 1982-05-14 | 1987-06-16 | Astra Meditec Ab | Process for providing articles with a biocompatible surface layer |
| US5541167A (en) * | 1991-05-31 | 1996-07-30 | Baxter International Inc. | Thromboresistant coating for defoaming applications |
| US5607475A (en) * | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
| US5679659A (en) * | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
| US5767108A (en) * | 1995-08-22 | 1998-06-16 | Medtronic, Inc. | Method for making improved heparinized biomaterials |
| US5782908A (en) * | 1995-08-22 | 1998-07-21 | Medtronic, Inc. | Biocompatible medical article and method |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7115133A (en) | 1972-05-08 |
| BE774852A (en) | 1972-05-03 |
| CA960584A (en) | 1975-01-07 |
| DE2154542A1 (en) | 1972-05-10 |
| FR2113524A5 (en) | 1972-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |