GB1317034A - 1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives - Google Patents
1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivativesInfo
- Publication number
- GB1317034A GB1317034A GB1317034DA GB1317034A GB 1317034 A GB1317034 A GB 1317034A GB 1317034D A GB1317034D A GB 1317034DA GB 1317034 A GB1317034 A GB 1317034A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- alkyl
- reacting
- substituted
- nov
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- -1 N-substituted piperazine Chemical class 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- XENVCRGQTABGKY-ZHACJKMWSA-N chlorohydrin Chemical compound CC#CC#CC#CC#C\C=C\C(Cl)CO XENVCRGQTABGKY-ZHACJKMWSA-N 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5285570 | 1970-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1317034A true GB1317034A (en) | 1973-05-16 |
Family
ID=10465582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1317034D Expired GB1317034A (en) | 1970-11-06 | 1970-11-06 | 1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE774860A (enrdf_load_stackoverflow) |
| DE (1) | DE2155132A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2112509B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1317034A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4060613A (en) * | 1976-05-19 | 1977-11-29 | Ayerst Mckenna And Harrison Ltd. | 3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof |
| US4118511A (en) | 1976-05-19 | 1978-10-03 | Ayerst, Mckenna & Harrison Limited | Aryloxy aminobutanols for alleviating symptoms of depression |
| US4170653A (en) | 1976-05-19 | 1979-10-09 | Ayerst McKenna and Harrison Limited | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers |
| EP0068324A3 (en) * | 1981-06-19 | 1983-07-27 | Tanabe Seiyaku Co., Ltd. | Microcapsule preparation for reducing increased intracranial pressure and a process for preparing the same |
| US5342839A (en) * | 1988-09-21 | 1994-08-30 | Basf Aktiengesellschaft | 2-hydroxy-3-phenoxy-propyl-substituted piperazines, their preparation and use |
| US5643909A (en) * | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| US6130219A (en) * | 1996-06-17 | 2000-10-10 | Eli Lilly And Company | Drug resistance and multidrug resistance modulators |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2235597A1 (de) * | 1972-07-20 | 1974-01-31 | Boehringer Mannheim Gmbh | 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung |
| JPS5697227A (en) * | 1979-12-28 | 1981-08-05 | Tanabe Seiyaku Co Ltd | Intracranial hypotensor |
| ATE294779T1 (de) * | 1997-10-31 | 2005-05-15 | Daiichi Suntory Pharma Co Ltd | Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika |
-
1970
- 1970-11-06 GB GB1317034D patent/GB1317034A/en not_active Expired
-
1971
- 1971-11-03 BE BE774860A patent/BE774860A/xx unknown
- 1971-11-05 FR FR7139844A patent/FR2112509B1/fr not_active Expired
- 1971-11-05 DE DE19712155132 patent/DE2155132A1/de active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4060613A (en) * | 1976-05-19 | 1977-11-29 | Ayerst Mckenna And Harrison Ltd. | 3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof |
| US4118511A (en) | 1976-05-19 | 1978-10-03 | Ayerst, Mckenna & Harrison Limited | Aryloxy aminobutanols for alleviating symptoms of depression |
| US4170653A (en) | 1976-05-19 | 1979-10-09 | Ayerst McKenna and Harrison Limited | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers |
| EP0068324A3 (en) * | 1981-06-19 | 1983-07-27 | Tanabe Seiyaku Co., Ltd. | Microcapsule preparation for reducing increased intracranial pressure and a process for preparing the same |
| US5342839A (en) * | 1988-09-21 | 1994-08-30 | Basf Aktiengesellschaft | 2-hydroxy-3-phenoxy-propyl-substituted piperazines, their preparation and use |
| US5643909A (en) * | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| US5654304A (en) * | 1993-04-19 | 1997-08-05 | Syntex (U.S.A.) Inc. | 10,11-methanodibenzosuberane derivatives |
| US5889007A (en) * | 1993-04-19 | 1999-03-30 | Syntex (U.S.A.) Inc. | 10, 11-methanodibenzosuberane derivatives |
| US6087365A (en) * | 1993-04-19 | 2000-07-11 | Pfister; Jurg R. | 10,11-methanodibenzosuberane derivatives |
| US6130219A (en) * | 1996-06-17 | 2000-10-10 | Eli Lilly And Company | Drug resistance and multidrug resistance modulators |
| US6180633B1 (en) | 1996-06-17 | 2001-01-30 | Eli Lilly And Company | Drug resistance and multidrug resistance modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| BE774860A (fr) | 1972-05-03 |
| FR2112509B1 (enrdf_load_stackoverflow) | 1975-08-01 |
| FR2112509A1 (enrdf_load_stackoverflow) | 1972-06-16 |
| DE2155132A1 (de) | 1972-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1467471A (en) | Derivatives of 1,3-disubstituted-2,4-quinazolinediones | |
| GB1383409A (en) | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them | |
| GB1467927A (en) | Derivatives of tyrosine having a pharmaceutical activity on smooth muscles | |
| GB1317034A (en) | 1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives | |
| GB1135893A (en) | Imidazo (1,2-b) pyridazine derivatives | |
| GB1320395A (en) | Heterocyclic ethers of 1-substituted-4-hydroxyalkyl piperazines and process for preparing them | |
| GB1337280A (en) | 5-phenyl-isoxazole-3-carboxylic acids and their derivatives | |
| GB1506914A (en) | 2-dihalophenylamino-2-imidazoline derivatives | |
| GB1369248A (en) | Amides the preparation thereof and their use in pharmacjeutical compositions | |
| GB1436533A (en) | Aryl piperazine derivatives of adenine | |
| GB1317479A (en) | 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives | |
| GB1431414A (en) | Prostanoic acid derivatives | |
| GB1186495A (en) | 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation | |
| GB1125112A (en) | New derivatives of diazabicyclo-decane and process for preparing them | |
| GB1453417A (en) | Nitroimidazoles | |
| GB1174349A (en) | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof | |
| GB1437023A (en) | Substituted benzene-1,3-disulphonamides and process for their manufacture | |
| GB1353536A (en) | Antiviral compositions containing bisbasic ethers and thioethers of xanthene and xanthen-9-ones and methods of treating viruses therewith | |
| GB1156781A (en) | New Heterocyclic Compounds | |
| GB1292787A (en) | Benzodioxane derivatives and pharmaceutical compositions containing them | |
| GB1356406A (en) | Indole derivatives | |
| GB1392194A (en) | Pyrrolidine derivatives | |
| GB1264068A (enrdf_load_stackoverflow) | ||
| GB1175617A (en) | Substituted Pteridine Derivatives | |
| GB1340637A (en) | Dibenzocycloheptadioxolan derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |