GB1313373A - Polysaccharides having anti-tumour activity and process for their production - Google Patents

Polysaccharides having anti-tumour activity and process for their production

Info

Publication number
GB1313373A
GB1313373A GB3397270A GB3397270A GB1313373A GB 1313373 A GB1313373 A GB 1313373A GB 3397270 A GB3397270 A GB 3397270A GB 3397270 A GB3397270 A GB 3397270A GB 1313373 A GB1313373 A GB 1313373A
Authority
GB
United Kingdom
Prior art keywords
glucan
linkages
cleaved
july
oxidized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3397270A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of GB1313373A publication Critical patent/GB1313373A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

1313373 #-(1#3)-Glucans AJINOMOTO CO Inc 13 July 1970 [14 July 1969] 33972/70 Heading C3U A #-(1 # 3)-glucan having anti-tumou<SP>r</SP> activity possesses aldehyde groups derived by oxidation of glycol linkages of a glucan having #-(1 # 3) linkages in the main chain and at least one linkage selected from α-(1 # 2), #-(1 # 2), α-(1 # 4), #-(1 # 4), α-(1 # 6) and #-(1 # 6) linkages in the main chain and/or in a side chain. The starting glucan may be #-pachyman or laminarin. The glycol link may be cleaved using, e.g., periodic acid, sodium periodate or lead tetra-acetate, in aqueous solution in the dark, and at 0-300‹ C., for 20-72 hours. The cleaved #-(1 # 3)-glucan product may be modified to increase stability by reduction of some of the aldehyde groups to hydroxymethyl groups, using sodium borohydride or lithium aluminium hydride. Similarly the oxidized glucan, or the oxidized and reduced glucan, may be subjected to mild hydrolysis, using, e.g., dilute aqueous H 2 SO 4 at 5-30‹ C.
GB3397270A 1969-07-14 1970-07-13 Polysaccharides having anti-tumour activity and process for their production Expired GB1313373A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5561269 1969-07-14

Publications (1)

Publication Number Publication Date
GB1313373A true GB1313373A (en) 1973-04-11

Family

ID=13003572

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3397270A Expired GB1313373A (en) 1969-07-14 1970-07-13 Polysaccharides having anti-tumour activity and process for their production

Country Status (3)

Country Link
CA (1) CA965782A (en)
FR (1) FR2059511B1 (en)
GB (1) GB1313373A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3032636A1 (en) * 1979-08-29 1981-04-09 Meito Sangyo K.K., Nagoya (BETA) -1,3-GLUCANPOLYOL, METHOD FOR THE PRODUCTION THEREOF AND TUMOR TREATMENT CONTAINING THIS COMPOUND
WO2013183049A1 (en) * 2012-06-04 2013-12-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antiviral application of compositions comprising glucan

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3032636A1 (en) * 1979-08-29 1981-04-09 Meito Sangyo K.K., Nagoya (BETA) -1,3-GLUCANPOLYOL, METHOD FOR THE PRODUCTION THEREOF AND TUMOR TREATMENT CONTAINING THIS COMPOUND
WO2013183049A1 (en) * 2012-06-04 2013-12-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antiviral application of compositions comprising glucan

Also Published As

Publication number Publication date
FR2059511A1 (en) 1971-06-04
CA965782A (en) 1975-04-08
FR2059511B1 (en) 1973-08-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee