GB1308161A - Process for the manufacture of peptides - Google Patents
Process for the manufacture of peptidesInfo
- Publication number
- GB1308161A GB1308161A GB1627470A GB1627470A GB1308161A GB 1308161 A GB1308161 A GB 1308161A GB 1627470 A GB1627470 A GB 1627470A GB 1627470 A GB1627470 A GB 1627470A GB 1308161 A GB1308161 A GB 1308161A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pro
- phe
- peptide
- amino acid
- protected amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
Abstract
1308161 Peptide process; benzotriazoles FARBWERKE HOECHST AG 6 April 1970 [5 April 1969 24 July 1969] 16274/70 Heading C2C In a process for preparing a peptide a protected amino acid or peptide containing a free carboxylic group is reacted with a protected amino acid or peptide containing a free amino group in a conventional solvent and in the presence of a carbodiimide and 1-2 equivalents of a benzotriazole (I) where R is H, halogen, CF 3 , alkyl, nitro, carboxamide sulphonic acid amide, cyano, methoxy or ethoxy and n is 1-4 and optionally the protecting groups are removed. The invention also comprises compounds (I) where R is as defined but not H. In the process (I) is preferably reacted with a protected amino acid or peptide to form an activated ester before condensation with the free amine. Compounds (I) are prepared by condensing an o-chloronitro-benzene with hydrazine. Examples include the preparation of 1-23 ACTH, the protected decapeptide having the sequence of antamanide (Z - Phe - Phe - Pro - Pro - Phe - Phe - Val - Pro- Pro-Ala-OtBu), sequence 54-63 of pigs proinsulin (Z-Leu-Ala-Leu-Glu(OtBu)-Gly-Pro-Pro- GlN-Lys(BOC)-ArgOH) together with other smaller peptides and their intermediates and starting products.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691917690 DE1917690C3 (en) | 1969-04-05 | 1969-04-05 | Process for the production of peptides |
DE19691937656 DE1937656C3 (en) | 1969-07-24 | 1969-07-24 | Process for the production of peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1308161A true GB1308161A (en) | 1973-02-21 |
Family
ID=25757250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1627470A Expired GB1308161A (en) | 1969-04-05 | 1970-04-06 | Process for the manufacture of peptides |
Country Status (11)
Country | Link |
---|---|
BE (1) | BE748545A (en) |
CH (1) | CH551948A (en) |
DK (1) | DK126184B (en) |
FI (1) | FI53122C (en) |
FR (1) | FR2042968A5 (en) |
GB (1) | GB1308161A (en) |
HU (1) | HU164903B (en) |
IL (1) | IL34230A (en) |
NL (1) | NL166924C (en) |
NO (1) | NO129567B (en) |
SE (1) | SE352341B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986003494A1 (en) * | 1984-12-11 | 1986-06-19 | Lkb Biochrom Limited | Method for a solid phase synthesis of a linear combination of amino acid residues |
AU597031B2 (en) * | 1986-02-03 | 1990-05-24 | Novabiochem Ag | Monitoring method for the synthesis of a linear combination of amino acid residues |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1226552B (en) * | 1988-07-29 | 1991-01-24 | Ellem Ind Farmaceutica | IMMUNOSTIMULANT PEPTIDES. |
-
1970
- 1970-04-01 CH CH483870A patent/CH551948A/en not_active IP Right Cessation
- 1970-04-01 HU HUHO1275A patent/HU164903B/hu unknown
- 1970-04-02 IL IL34230A patent/IL34230A/en unknown
- 1970-04-02 NO NO01217/70*[A patent/NO129567B/no unknown
- 1970-04-03 NL NL7004811.A patent/NL166924C/en not_active IP Right Cessation
- 1970-04-03 FI FI933/70A patent/FI53122C/fi active
- 1970-04-03 SE SE04597/70A patent/SE352341B/xx unknown
- 1970-04-03 DK DK169770AA patent/DK126184B/en unknown
- 1970-04-06 FR FR7012341A patent/FR2042968A5/fr not_active Expired
- 1970-04-06 GB GB1627470A patent/GB1308161A/en not_active Expired
- 1970-04-06 BE BE748545D patent/BE748545A/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986003494A1 (en) * | 1984-12-11 | 1986-06-19 | Lkb Biochrom Limited | Method for a solid phase synthesis of a linear combination of amino acid residues |
AU597031B2 (en) * | 1986-02-03 | 1990-05-24 | Novabiochem Ag | Monitoring method for the synthesis of a linear combination of amino acid residues |
Also Published As
Publication number | Publication date |
---|---|
BE748545A (en) | 1970-10-06 |
FI53122B (en) | 1977-10-31 |
DK126184B (en) | 1973-06-18 |
IL34230A0 (en) | 1970-06-17 |
FI53122C (en) | 1978-02-10 |
NL7004811A (en) | 1970-10-07 |
FR2042968A5 (en) | 1971-02-12 |
NL166924C (en) | 1981-10-15 |
SU439967A3 (en) | 1974-08-15 |
SE352341B (en) | 1972-12-27 |
NL166924B (en) | 1981-05-15 |
NO129567B (en) | 1974-04-29 |
CH551948A (en) | 1974-07-31 |
HU164903B (en) | 1974-05-28 |
IL34230A (en) | 1973-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PE20 | Patent expired after termination of 20 years |