GB1298157A - BENZO-(b)-THIOPHENE DERIVATIVES AND COMPOSITIONS CONTAINING THE SAME - Google Patents

BENZO-(b)-THIOPHENE DERIVATIVES AND COMPOSITIONS CONTAINING THE SAME

Info

Publication number
GB1298157A
GB1298157A GB1097370A GB1097370A GB1298157A GB 1298157 A GB1298157 A GB 1298157A GB 1097370 A GB1097370 A GB 1097370A GB 1097370 A GB1097370 A GB 1097370A GB 1298157 A GB1298157 A GB 1298157A
Authority
GB
United Kingdom
Prior art keywords
thiophene
tetrahydrobenzo
carbamoyl
benzo
thiophene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1097370A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CT D ETUDES POUR L IND PHARMA
Centre dEtudes pour lIndustrie Pharmaceutique
Original Assignee
CT D ETUDES POUR L IND PHARMA
Centre dEtudes pour lIndustrie Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CT D ETUDES POUR L IND PHARMA, Centre dEtudes pour lIndustrie Pharmaceutique filed Critical CT D ETUDES POUR L IND PHARMA
Publication of GB1298157A publication Critical patent/GB1298157A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1298157 Benzo(b)thiophene derivatives CENTRE D'ETUDES POUR L'INDUSTRIE PHARMACEUTIQUE 6 March 1970 [7 March 1969] 10973/70 Heading C2C Novel benzo(b)thiophene derivatives of the formula wherein A is C 1-6 alkylene; and R and R<SP>1</SP>, which may be the same or different, each are H, or optionally substituted alkyl, cycloalkyl or aralkyl, or R and R<SP>1</SP> together with the nitrogen atom to which they are attached form a 5-7. membered saturated heterocyclic ring, optionally containing further hetero atoms, and/or opt - ionally substituted by one or more C 1-4 alkyl or C 1-4 hydroxyalkyl groups; and acid addition and quaternary ammonium salts thereof, are prepared by reacting the appropriate 3-carbamoyl - 2 - haloacylamino - 4,5,6,7 - tetrahydrobenzo(b)thiophenes with compounds of the formula 2 - (Chloroacetylamino)- 3 - carbamoyl - 4,5,6, 7 - tetrahydrobenzo(b)thiophene and 2 - (3- bromopropionylamino)- 3 - carbamoyl - 4,5,6,7- tetrahydrobenzo(b)thiophene are obtained by reacting 2 - amino - 3 - carbamoyl - 4,5,6,7 - tetrahydrobenzo(b)thiophene with chloroacetyl chloride and 3-bromopropionyl bromide respectively. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above novel compounds or physiologically acceptable acid addition or quaternary ammonium salts thereof, in association with pharmaceutical carriers and/or excipients. The compositions have anti-arrhythmic, anti-histaminic, anti-tussive and anti-inflammatory activities and may also be used as local anaesthetics.
GB1097370A 1969-03-07 1970-03-06 BENZO-(b)-THIOPHENE DERIVATIVES AND COMPOSITIONS CONTAINING THE SAME Expired GB1298157A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6906389A FR2035767A1 (en) 1969-03-07 1969-03-07

Publications (1)

Publication Number Publication Date
GB1298157A true GB1298157A (en) 1972-11-29

Family

ID=9030273

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1097370A Expired GB1298157A (en) 1969-03-07 1970-03-06 BENZO-(b)-THIOPHENE DERIVATIVES AND COMPOSITIONS CONTAINING THE SAME

Country Status (2)

Country Link
FR (1) FR2035767A1 (en)
GB (1) GB1298157A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2128234A1 (en) * 1971-03-12 1972-10-20 Centre Etd Ind Pharma Compsns contg 2-amino-4,5,6,7-tetrahydrobenzo (b) thiophen - -3-carboxamide - with analgesic,sedative,antitussive and diuretic act
CA1094063A (en) * 1977-08-22 1981-01-20 Davis L. Temple, Jr. Thieno ¬2,3-d| pyrimidine antiallergic agents

Also Published As

Publication number Publication date
FR2035767A1 (en) 1970-12-24

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee