GB1297398A - - Google Patents
Info
- Publication number
- GB1297398A GB1297398A GB1297398DA GB1297398A GB 1297398 A GB1297398 A GB 1297398A GB 1297398D A GB1297398D A GB 1297398DA GB 1297398 A GB1297398 A GB 1297398A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fatty acid
- tetraacylcytidine
- aug
- derivatives
- yakuhun
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1297398 Tetraacylcytidine derivatives TAKEDA YAKUHUN KOGYO KK 4 Aug 1970 [6 Aug 1969] 37522/70 Heading C2C Novel N<SP>4</SP>,O<SP>2#</SP>,O<SP>3#</SP>,O<SP>5#</SP>-tetraacylcytidine derivatives wherein the acyl group is derived from a fatty acid containing 3 to 18 carbon atoms are prepared by acylating cytidine with the appropriate fatty acid anhydrides or fatty acid halides. Pharmaceutical compositions, suitable for oral or parenteral administration, and having central nervous system activating effects, contain the above novel compound and pharmaceutically acceptable diluents and carriers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6218669 | 1969-08-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1297398A true GB1297398A (en) | 1972-11-22 |
Family
ID=13192837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1297398D Expired GB1297398A (en) | 1969-08-06 | 1970-08-04 |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE2038807A1 (en) |
FR (1) | FR2068467B1 (en) |
GB (1) | GB1297398A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994013687A1 (en) * | 1992-12-08 | 1994-06-23 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
WO1994026761A1 (en) * | 1993-05-14 | 1994-11-24 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
US5583117A (en) * | 1987-10-28 | 1996-12-10 | Pro-Neuron, Inc. | Acylated uridine and cytidine for elevating tissue uridine and cytidine |
US5691320A (en) * | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
US5736531A (en) * | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US6329350B1 (en) | 1987-10-28 | 2001-12-11 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
WO2005049633A1 (en) * | 2003-11-03 | 2005-06-02 | Cognis Ip Management Gmbh | Acyl ribonucleosides and acyl deoxyribonucleosides |
US7709459B2 (en) | 1994-07-01 | 2010-05-04 | Wellstat Therapeutics Corporation | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US7776838B1 (en) | 1987-10-28 | 2010-08-17 | Wellstat Therapeutics Corporation | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US8067392B2 (en) | 1998-08-31 | 2011-11-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US10500224B2 (en) * | 2013-11-14 | 2019-12-10 | Kainos Medicine, Inc. | Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4177348A (en) | 1977-12-13 | 1979-12-04 | United States Government | Carbocyclic analogs of cytosine nucleosides |
US4232154A (en) | 1977-12-13 | 1980-11-04 | United States Of America | Carbocyclic analogs of cytosine nucleosides exhibiting antiviral and antineoplasticactivity |
EP3453386A1 (en) * | 2017-09-08 | 2019-03-13 | Universite D'angers | Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1539372A (en) * | 1966-12-17 | 1968-09-13 | Tokyo Tanabe Co | Process for the production of riboflavin esters and new products thus obtained |
-
1970
- 1970-08-04 GB GB1297398D patent/GB1297398A/en not_active Expired
- 1970-08-05 FR FR7028893A patent/FR2068467B1/fr not_active Expired
- 1970-08-05 DE DE19702038807 patent/DE2038807A1/en active Pending
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274563B1 (en) | 1987-10-28 | 2001-08-14 | Pro-Neuron, Inc. | Acylated uridine and cytidine and uses thereof |
US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
US6316426B1 (en) | 1987-10-28 | 2001-11-13 | Pro-Neuron, Inc. | Acylated uridine and cytidine and uses thereof |
US5583117A (en) * | 1987-10-28 | 1996-12-10 | Pro-Neuron, Inc. | Acylated uridine and cytidine for elevating tissue uridine and cytidine |
US5691320A (en) * | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
US5736531A (en) * | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US7776838B1 (en) | 1987-10-28 | 2010-08-17 | Wellstat Therapeutics Corporation | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US6329350B1 (en) | 1987-10-28 | 2001-12-11 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US6258795B1 (en) | 1987-10-28 | 2001-07-10 | Pro-Neuron, Inc. | Acylated uridine and cytidine and uses thereof |
US7173017B1 (en) | 1987-10-28 | 2007-02-06 | Wellstat Therapeutics Corporation | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US7166581B1 (en) | 1987-10-28 | 2007-01-23 | Wellstat Therapeutics Corporation | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US6232298B1 (en) | 1987-10-28 | 2001-05-15 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US6344447B2 (en) | 1987-10-28 | 2002-02-05 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US7105498B2 (en) | 1987-10-28 | 2006-09-12 | Wellstat Therapeutics Corporation | Acylated uridine and cytidine and uses thereof |
AU732120B2 (en) * | 1992-12-08 | 2001-04-12 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
WO1994013687A1 (en) * | 1992-12-08 | 1994-06-23 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
WO1994026761A1 (en) * | 1993-05-14 | 1994-11-24 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US7709459B2 (en) | 1994-07-01 | 2010-05-04 | Wellstat Therapeutics Corporation | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US8067392B2 (en) | 1998-08-31 | 2011-11-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
WO2005049633A1 (en) * | 2003-11-03 | 2005-06-02 | Cognis Ip Management Gmbh | Acyl ribonucleosides and acyl deoxyribonucleosides |
US10500224B2 (en) * | 2013-11-14 | 2019-12-10 | Kainos Medicine, Inc. | Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment |
Also Published As
Publication number | Publication date |
---|---|
FR2068467B1 (en) | 1974-08-23 |
FR2068467A1 (en) | 1971-08-27 |
DE2038807A1 (en) | 1971-02-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1297398A (en) | ||
GB1504070A (en) | Prostaglandin salt | |
GB1275181A (en) | Ester ofhydroxyethylpiperazinylpropylidenetrifuoro-methyl-thiaxanthene | |
GB1274809A (en) | Evomonoside derivatives | |
GB1436080A (en) | Ellipticine derivative and pharmaceutical uses thereof | |
GB1420739A (en) | 3-alkenyl dibenzo-b,d-pyran compounds | |
GB1187825A (en) | Ribofuranosyl Derivatives | |
GB1434074A (en) | Antiviral compositions comprising hydantoin derivatives | |
GB1252286A (en) | ||
GB1141214A (en) | New derivatives of proscillaridin a | |
GB1390402A (en) | Substituted imidazolecarboxamides | |
GB1283632A (en) | Phenylethanolamine derivatives | |
GB1269832A (en) | TRICYCLO(4.4.0.0<3.8>)DECAN-1-AMINE AND alpha-METHYLTRICYCLO(4.4.0.0<3.8>)DECAN-1-METHYLAMINE AND PROCESS FOR PREPARING SAME | |
GB1203538A (en) | Cubane derivatives | |
GB1421787A (en) | Substituted imidazoles | |
GB1266889A (en) | ||
GB1173562A (en) | Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them | |
GB1424348A (en) | Isoquinoline derivatives | |
GB1271519A (en) | Improvements in or relating to derivatives of phloroglucinol | |
GB1272340A (en) | Derivatives of neriifolin | |
GB1282822A (en) | Butanolamine derivatives | |
GB1332635A (en) | Rutin complexes | |
GB1167407A (en) | Novel Reserpine Derivative having Pharmacological Activity and Compositions containing the said Derivative | |
GB1504227A (en) | Digoxin derivatives | |
ES469648A1 (en) | Oleandomycin derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |