GB1294769A - Process for producing cytidine diphosphate choline - Google Patents

Process for producing cytidine diphosphate choline

Info

Publication number
GB1294769A
GB1294769A GB5555270A GB5555270A GB1294769A GB 1294769 A GB1294769 A GB 1294769A GB 5555270 A GB5555270 A GB 5555270A GB 5555270 A GB5555270 A GB 5555270A GB 1294769 A GB1294769 A GB 1294769A
Authority
GB
United Kingdom
Prior art keywords
cytidine
choline
cells
diphosphate
genera
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5555270A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of GB1294769A publication Critical patent/GB1294769A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/305—Pyrimidine nucleotides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1294769 Cytidine diphosphate choline ASAHI KASEI KOGYO KK 23 Nov 1970 [26 Nov 1969] 55552/70 Heading C2P Cytidine diphosphate choline is produced by applying an enzyme, contained in the cells of a micro-organism having a fructose-1,6-diphosphate producing ability from carbohydrates of at least 20% by weight of inorganic phosphate consumption in 5 to 8 hours, to a liquid medium containing 5<SP>1</SP>-cytidylic acid, a salt thereof, cytidine or cytosine, together with choline, a salt thereof or phosphatidyl choline, and a phosphoric acid donor, a carbohydrate and a magnesium salt. The phosphoric acid donor may be sodium phosphate, potassium dihydrogen phosphate or dipotassium hydrogen phosphate, the carbohydrate may be glucose, sucrose, fructose or maltose, and the magnesium salt may be the sulphate or chloride., The enzyme may be used in the form of a culture medium of the microorganism, cells thereof, dried cells, cell extracts or ground cells. Suitable micro-organisms are (a) yeasts of the Brettanomyces, Torulopsis, Candida, Saccharomyces, Zygosaccharomyces, Debaryomyces and Pichia genera, (b) bacteria of the Microbacterium, Corynebacterium and Brevibacterium genera and (c) fungi of the Mucor and Aspergillus genera. The reaction may be carried out at 20-45‹ C. at pH 6 to 9. Small amounts of cytidine-5<SP>1</SP>-triphosphate and cytidine-5<SP>1</SP>-diphosphate may also be produced.
GB5555270A 1969-11-26 1970-11-23 Process for producing cytidine diphosphate choline Expired GB1294769A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9428969A JPS5140159B1 (en) 1969-11-26 1969-11-26

Publications (1)

Publication Number Publication Date
GB1294769A true GB1294769A (en) 1972-11-01

Family

ID=14106086

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5555270A Expired GB1294769A (en) 1969-11-26 1970-11-23 Process for producing cytidine diphosphate choline

Country Status (4)

Country Link
JP (1) JPS5140159B1 (en)
CH (1) CH504530A (en)
FR (1) FR2069340A5 (en)
GB (1) GB1294769A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387667B1 (en) 1992-01-30 2002-05-14 Kyowa Hakko Kogyo, Co., Ltd. Process for producing cytidine diphosphate choline

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5542623A (en) * 1978-09-19 1980-03-26 Matsushita Electric Ind Co Ltd Small electric cleaner
AT364485B (en) * 1980-06-10 1981-10-27 Franz Lex HAND BRUSH SUCTION UNIT

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789254A (en) * 1971-09-30 1973-03-26 Synthelabo NEW AMINO-ESTERS
JPS4841555A (en) * 1971-10-01 1973-06-18
JPS537424B2 (en) * 1971-10-08 1978-03-17

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387667B1 (en) 1992-01-30 2002-05-14 Kyowa Hakko Kogyo, Co., Ltd. Process for producing cytidine diphosphate choline

Also Published As

Publication number Publication date
DE2054785B2 (en) 1975-07-31
FR2069340A5 (en) 1971-09-03
CH504530A (en) 1971-03-15
JPS5140159B1 (en) 1976-11-01
DE2054785A1 (en) 1971-06-03

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Legal Events

Date Code Title Description
PS Patent sealed
48R Reference inserted (sect. 8/1949)
PCNP Patent ceased through non-payment of renewal fee