GB1270918A - Preparation of multivalent vaccines - Google Patents

Preparation of multivalent vaccines

Info

Publication number
GB1270918A
GB1270918A GB5325570A GB5325570A GB1270918A GB 1270918 A GB1270918 A GB 1270918A GB 5325570 A GB5325570 A GB 5325570A GB 5325570 A GB5325570 A GB 5325570A GB 1270918 A GB1270918 A GB 1270918A
Authority
GB
United Kingdom
Prior art keywords
culture
viruses
centrifuge
nov
viral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5325570A
Inventor
Philip Peter Vella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1270918A publication Critical patent/GB1270918A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
    • C12N2760/18734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

1,270,918. Multivalent vaccines. MERCK & CO., Inc. 9 Nov., 1970 [14 Nov., 1969], No. 53255/70. Heading A5B. A multivalent vaccine may be produced by simultaneously cultivating a number of viral agents in a single cell culture medium and incorporating the culture in a pharmaceutically acceptable carrier. The viral agents may be respitory syncytial virus, parainfluenza viruses, influenza virus strains A and B, infection bronchitis-like viruses and mycoplasma pneumoniae. The culture cells may be African Green Monkey Kidney cells. In Example I the cultured viruses are harvested, inactivated with aqueous formaldehyde and adsorbed on potassium aluminium sulphate. In Example 3 the culture contains neomycin. The virus product is clarified in a centrifuge, fractionated in an ultra-centrifuge and used in aqueous medium.
GB5325570A 1969-11-14 1970-11-09 Preparation of multivalent vaccines Expired GB1270918A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87702769A 1969-11-14 1969-11-14

Publications (1)

Publication Number Publication Date
GB1270918A true GB1270918A (en) 1972-04-19

Family

ID=25369101

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5325570A Expired GB1270918A (en) 1969-11-14 1970-11-09 Preparation of multivalent vaccines

Country Status (5)

Country Link
AU (1) AU2183370A (en)
DE (1) DE2056051A1 (en)
FR (1) FR2073358B1 (en)
GB (1) GB1270918A (en)
NL (1) NL7015493A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351827A (en) * 1979-07-17 1982-09-28 Gist-Brocades N.V. Novel polyvalent virus vaccine
US4358438A (en) * 1979-07-17 1982-11-09 Gist-Brocades N.V. Novel polyvalent virus vaccine against rabies and canine distemper
US4657761A (en) * 1985-06-05 1987-04-14 Pinto Cesar M Polyvalent non-specific immuno-stimulating vaccine and method
WO2000062802A2 (en) * 1999-04-20 2000-10-26 Smithkline Beecham Biologicals Sa Vaccine comprising rsv antigen and cpg oligonucleotide
WO2005017201A1 (en) * 2003-08-01 2005-02-24 University Of South Florida Method of treating herpes virus infections

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351827A (en) * 1979-07-17 1982-09-28 Gist-Brocades N.V. Novel polyvalent virus vaccine
US4358438A (en) * 1979-07-17 1982-11-09 Gist-Brocades N.V. Novel polyvalent virus vaccine against rabies and canine distemper
US4657761A (en) * 1985-06-05 1987-04-14 Pinto Cesar M Polyvalent non-specific immuno-stimulating vaccine and method
WO2000062802A2 (en) * 1999-04-20 2000-10-26 Smithkline Beecham Biologicals Sa Vaccine comprising rsv antigen and cpg oligonucleotide
WO2000062802A3 (en) * 1999-04-20 2001-01-11 Smithkline Beecham Biolog Vaccine comprising rsv antigen and cpg oligonucleotide
WO2005017201A1 (en) * 2003-08-01 2005-02-24 University Of South Florida Method of treating herpes virus infections

Also Published As

Publication number Publication date
AU2183370A (en) 1972-05-04
DE2056051A1 (en) 1971-05-27
NL7015493A (en) 1971-05-18
FR2073358A1 (en) 1971-10-01
FR2073358B1 (en) 1974-02-22

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