GB1265562A - - Google Patents
Info
- Publication number
- GB1265562A GB1265562A GB1265562DA GB1265562A GB 1265562 A GB1265562 A GB 1265562A GB 1265562D A GB1265562D A GB 1265562DA GB 1265562 A GB1265562 A GB 1265562A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiopeptin
- chloroform
- chcl
- mol
- spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1,265,562. The antibiotic thiopeptin. FUJISAWA PHARMACEUTICAL CO. Ltd. 12 June, 1969 [12 June, 1968], No. 29964/69. Heading C2A. The new antibiotic complex thiopeptin is produced by aerobically cultivating Streptomyces tateyamensis in an aqueous medium containing assimilable sources of nitrogen and carbon. Thiopeptin comprises components A 1 , A 3 and B, which have in common the following properties: they are yellow crystalline solids, soluble in dioxane, dimethylsulphoxide, dimethylformamide, pyridine, chloroform and 3N.HCl; slightly soluble in methanol, acetone and ethyl acetate and insoluble in ether, benzene, n-hexane, petroleum ether and water; giving a + ve permanganate test, a - ve reaction to ninhydrin, biuret, Fehling's, FeCl 3 , Ehrlich's and Dragendorff's tests; stable at 60‹ C. for 1 hour at pH 2-8, and giving amino-acid components on hydrolysis with 6N.HCl at 100‹ C. Thiopeptin A 1 is additionally characterized by a melting point of 223-226‹ C; [α]<SP>23</SP> D = - 71‹ (C = 1À0 in CHCl 3 ); elementary analysis C= 49.38%, H = 4À93%, N = 14À22%, S = 11À72%, mol. wt.= 1637; U.V. absorption shoulders at 230-250 mÁ, 295 mÁ and 305 mÁ; and an I.R. spectrum as shown in Fig. 5. Thiopeptin A 3 is characterized by: melting point 232-236‹C.; [α]<SP>23</SP>D = - 10À8‹ (C = 1À0 in CHCl 3 ); elementary analysis C = 48À45%, H = 5À11 %, N = 14À46%, S = 12À09%; mol. wt.= 1972; U.V. absorption shoulders at 235-255 mÁ, 285-300 mÁ and 302-310 mÁ ; and an I.R. spectrum as shown in Fig. 6. Thiopeptin B melts at 219-222‹ C.; [α] D <SP>23</SP> = - 80‹ (C = 1À0 in CHCl 3 ); elementary analysis C = 49À26%, H = 5À16%, N = 14À35%, S= 10À68%; mol. wt.= 1942; U.V. shoulders at 230-250 mÁ, 295 mÁ and 305 mÁ, and an I.R. spectrum as shown in Fig. 7. The thiopeptin complex is isolated from the culture by extracting the filtered mycelium with acetone or a mixture of chloroform and methanol. concentrating the extract, redissolving in, e.g. chloroform and purifying or separating into the component substances by chromatography on silica gel with a chloroform/ methanol mixture followed by precipitation by adding a non-solvent. Animal feed supplements comprise a basal ration suitable for use as an animal feed together with thiopeptin complex, or a dried thiopeptin-containing mycelium cake from Streptomyces tateyamensis A.T.C.C. 21389 or a thiopeptin-producing strain thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4038668 | 1968-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1265562A true GB1265562A (en) | 1972-03-01 |
Family
ID=12579197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1265562D Expired GB1265562A (en) | 1968-06-12 | 1969-06-12 |
Country Status (10)
Country | Link |
---|---|
BE (1) | BE734395A (en) |
CA (1) | CA960167A (en) |
CH (1) | CH515327A (en) |
DE (1) | DE1929355C3 (en) |
DK (2) | DK125654B (en) |
FR (1) | FR2010751A1 (en) |
GB (1) | GB1265562A (en) |
IT (1) | IT1045476B (en) |
NL (1) | NL164606C (en) |
SE (2) | SE370006B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1090728A (en) * | 1976-02-04 | 1980-12-02 | Eli Lilly And Company | Antibiotic a-7413 mixture comprising factors a,b,c and d and a process for producing it |
CH629654A5 (en) * | 1977-05-26 | 1982-05-14 | Ciba Geigy Ag | FEED ADDITIVES. |
JPS5452731A (en) * | 1977-09-14 | 1979-04-25 | Fujisawa Pharmaceut Co Ltd | Animal growth accelerator |
-
1969
- 1969-06-10 DE DE1929355A patent/DE1929355C3/en not_active Expired
- 1969-06-11 CA CA054,098A patent/CA960167A/en not_active Expired
- 1969-06-11 FR FR6919383A patent/FR2010751A1/fr not_active Withdrawn
- 1969-06-11 SE SE08282/69A patent/SE370006B/xx unknown
- 1969-06-11 SE SE7304928A patent/SE387821B/en unknown
- 1969-06-11 BE BE734395D patent/BE734395A/xx not_active IP Right Cessation
- 1969-06-12 GB GB1265562D patent/GB1265562A/en not_active Expired
- 1969-06-12 NL NL6908968.A patent/NL164606C/en not_active IP Right Cessation
- 1969-06-12 IT IT18117/69A patent/IT1045476B/en active
- 1969-06-12 DK DK317069AA patent/DK125654B/en not_active IP Right Cessation
- 1969-06-12 CH CH900469A patent/CH515327A/en not_active IP Right Cessation
-
1971
- 1971-02-18 DK DK75371AA patent/DK129375B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NL164606B (en) | 1980-08-15 |
DK129375C (en) | 1975-02-24 |
NL6908968A (en) | 1969-12-16 |
BE734395A (en) | 1969-11-17 |
CA960167A (en) | 1974-12-31 |
SE387821B (en) | 1976-09-20 |
SE370006B (en) | 1974-09-30 |
DE1929355C3 (en) | 1981-08-06 |
FR2010751A1 (en) | 1970-02-20 |
IT1045476B (en) | 1980-05-10 |
DE1929355A1 (en) | 1969-12-18 |
DE1929355B2 (en) | 1980-12-18 |
CH515327A (en) | 1971-11-15 |
DK129375B (en) | 1974-10-07 |
NL164606C (en) | 1981-01-15 |
DK125654B (en) | 1973-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |