GB1260886A - Process for aryloxymethylmorpholine derivatives - Google Patents
Process for aryloxymethylmorpholine derivativesInfo
- Publication number
- GB1260886A GB1260886A GB5013069A GB5013069A GB1260886A GB 1260886 A GB1260886 A GB 1260886A GB 5013069 A GB5013069 A GB 5013069A GB 5013069 A GB5013069 A GB 5013069A GB 1260886 A GB1260886 A GB 1260886A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- compounds
- prepared
- chlorophenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 o-phenyl-phenyl Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 abstract 1
- XNIOWJUQPMKCIJ-UHFFFAOYSA-N 2-(benzylamino)ethanol Chemical compound OCCNCC1=CC=CC=C1 XNIOWJUQPMKCIJ-UHFFFAOYSA-N 0.000 abstract 1
- COMXZAIDKIXIKT-UHFFFAOYSA-N 2-(benzylamino)ethyl hydrogen sulfate Chemical compound OS(=O)(=O)OCCNCC1=CC=CC=C1 COMXZAIDKIXIKT-UHFFFAOYSA-N 0.000 abstract 1
- DJOGZXNBSUIGKG-UHFFFAOYSA-N 2-[(2-ethoxyphenoxy)methyl]oxirane Chemical compound CCOC1=CC=CC=C1OCC1OC1 DJOGZXNBSUIGKG-UHFFFAOYSA-N 0.000 abstract 1
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 abstract 1
- 150000002780 morpholines Chemical class 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL1970141132A PL88898B1 (cs) | 1969-10-13 | 1970-06-06 | |
US00044644A US3712890A (en) | 1969-06-20 | 1970-06-08 | Process for making 2-aryloxymethyl morpholines |
JP45052316A JPS5016795B1 (cs) | 1969-06-20 | 1970-06-16 | |
FI1718/70A FI61890C (fi) | 1969-06-20 | 1970-06-17 | Nytt foerfarande foer framstaellning av terapeutiskt anvaendbara 2-aryloximetylmorfoliner |
SE7008505A SE393377B (sv) | 1969-06-20 | 1970-06-18 | Sett att framstella morfolinderivat |
YU1553/70A YU35009B (en) | 1969-06-20 | 1970-06-18 | Process for preparing morpholine derivatives |
SU1451402A SU382287A3 (cs) | 1969-10-13 | 1970-06-18 | |
DK318670A DK143399C (da) | 1969-10-13 | 1970-06-19 | Fremgangsmaade til fremstilling af morfolinderivater |
CH936570A CH539068A (de) | 1969-06-20 | 1970-06-19 | Verfahren zur Herstellung von Morpholinderivaten |
NO2395/70A NO135939C (cs) | 1969-06-20 | 1970-06-19 | |
CS4319A CS167901B2 (cs) | 1969-10-13 | 1970-06-19 | |
ES380973A ES380973A1 (es) | 1969-06-20 | 1970-06-20 | Procedimiento para la preparacion de derivados de morfolina. |
HUIE399A HU162422B (cs) | 1969-06-20 | 1970-06-20 | |
US00299174A US3857839A (en) | 1969-06-20 | 1972-10-19 | For cyclising 1-aryloxy-3 beta-substituted ethylamino-2-propanols |
SE7605248A SE408419B (sv) | 1969-10-13 | 1976-05-07 | Sett att framstella morfolinderivat |
NO762973A NO137124C (no) | 1969-06-20 | 1976-08-30 | Fremgangsm}te for fremstilling av morfolinderivater |
YU2689/78A YU40208B (en) | 1969-06-20 | 1978-11-17 | Process for preparing morpholine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3125569 | 1969-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1260886A true GB1260886A (en) | 1972-01-19 |
Family
ID=10320364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5013069A Expired GB1260886A (en) | 1969-06-20 | 1969-06-20 | Process for aryloxymethylmorpholine derivatives |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT300820B (cs) |
BR (1) | BR6915221D0 (cs) |
CS (1) | CS167902B2 (cs) |
GB (1) | GB1260886A (cs) |
PL (1) | PL92088B1 (cs) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2575158A1 (fr) * | 1984-12-20 | 1986-06-27 | Pf Medicament | Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
WO1993015052A1 (en) * | 1992-01-28 | 1993-08-05 | Smithkline Beecham Plc | Compounds as calcium channel antagonists |
WO1998007710A1 (en) * | 1996-08-23 | 1998-02-26 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists |
WO2005105763A1 (en) * | 2004-04-30 | 2005-11-10 | Warner-Lambert Company Llc | Substituted morpholine compounds for the treatment of central nervous system disorders |
US7132551B2 (en) | 2000-09-11 | 2006-11-07 | Sepracor Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof |
US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
US8044052B2 (en) | 2006-10-18 | 2011-10-25 | Pfizer Inc. | Biaryl ether urea compounds |
WO2022198062A2 (en) | 2021-03-18 | 2022-09-22 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
WO2024206307A2 (en) | 2023-03-27 | 2024-10-03 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
-
1969
- 1969-06-20 GB GB5013069A patent/GB1260886A/en not_active Expired
- 1969-12-16 BR BR21522169A patent/BR6915221D0/pt unknown
-
1970
- 1970-06-06 PL PL18255570A patent/PL92088B1/pl unknown
- 1970-06-19 CS CS81470A patent/CS167902B2/cs unknown
- 1970-06-22 AT AT562170A patent/AT300820B/de not_active IP Right Cessation
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2575158A1 (fr) * | 1984-12-20 | 1986-06-27 | Pf Medicament | Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
EP0187096A1 (fr) * | 1984-12-20 | 1986-07-09 | Pierre Fabre Medicament | Arylalcoyloxymethyl-2 morpholines, leur préparation et leur application en tant que médicaments utiles dans le traitement des troubles du système nerveux central |
WO1993015052A1 (en) * | 1992-01-28 | 1993-08-05 | Smithkline Beecham Plc | Compounds as calcium channel antagonists |
WO1998007710A1 (en) * | 1996-08-23 | 1998-02-26 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists |
US6207662B1 (en) | 1996-08-23 | 2001-03-27 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine D4 receptor antagonists |
US6479491B1 (en) | 1996-08-23 | 2002-11-12 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists |
US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
US7132551B2 (en) | 2000-09-11 | 2006-11-07 | Sepracor Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof |
US7517892B2 (en) | 2000-09-11 | 2009-04-14 | Sepracor Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof |
US7816375B2 (en) | 2000-09-11 | 2010-10-19 | Sepracor Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof |
WO2005105763A1 (en) * | 2004-04-30 | 2005-11-10 | Warner-Lambert Company Llc | Substituted morpholine compounds for the treatment of central nervous system disorders |
US7659394B2 (en) | 2004-04-30 | 2010-02-09 | Pfizer Inc | Substituted morpholine compounds for the treatment of central nervous system disorders |
US8044052B2 (en) | 2006-10-18 | 2011-10-25 | Pfizer Inc. | Biaryl ether urea compounds |
WO2022198062A2 (en) | 2021-03-18 | 2022-09-22 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
WO2022198062A3 (en) * | 2021-03-18 | 2022-10-27 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
US11634415B2 (en) | 2021-03-18 | 2023-04-25 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
US11919889B2 (en) | 2021-03-18 | 2024-03-05 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
US12215097B2 (en) | 2021-03-18 | 2025-02-04 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
WO2024206307A2 (en) | 2023-03-27 | 2024-10-03 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
CS167902B2 (cs) | 1976-05-28 |
PL92088B1 (cs) | 1977-03-31 |
AT300820B (de) | 1972-08-10 |
BR6915221D0 (pt) | 1973-02-13 |
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