GB1244277A - Isolation of orgotein from blood - Google Patents
Isolation of orgotein from bloodInfo
- Publication number
- GB1244277A GB1244277A GB24140/69A GB2414069A GB1244277A GB 1244277 A GB1244277 A GB 1244277A GB 24140/69 A GB24140/69 A GB 24140/69A GB 2414069 A GB2414069 A GB 2414069A GB 1244277 A GB1244277 A GB 1244277A
- Authority
- GB
- United Kingdom
- Prior art keywords
- orgotein
- blood
- heating
- erythrocytes
- isolating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010070915 orgotein Proteins 0.000 title abstract 5
- 229960004534 orgotein Drugs 0.000 title abstract 5
- TUGDLVFMIQZYPA-UHFFFAOYSA-N tetracopper;tetrazinc Chemical compound [Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2] TUGDLVFMIQZYPA-UHFFFAOYSA-N 0.000 title abstract 5
- 210000004369 blood Anatomy 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 102000003846 Carbonic anhydrases Human genes 0.000 abstract 1
- 108090000209 Carbonic anhydrases Proteins 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012460 protein solution Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
1,244,277. Isolating orgotein from blood. DIAGNOSTIC DATA, Inc. 12 May, 1969 [13 May, 1968; 10 April, 1969], No. 24140/69. Heading A5B. [Also in Division C3] A process for isolating substantially pure orgotein from erythrocytes comprises separating the hemoglobin from hemolysed plasmafree erythrocytes; heating the hemolysate in a buffer solution having a pH range of from 1-4 and 6-11 containing divalent metal ions, e.g. Mg<SP>2+</SP>, Cu<SP>2+</SP> or Zn<SP>2+</SP>, until the carbonic anhydrase is inactivated; discontinuing the heating, removing all precipitated material and separating orgotein from the supernatant. A pharmaceutical composition comprises orgotein and a carrier, e.g. in the form of an injectable sterile protein solution. Fructose, sucrose or other saccharide may also be present.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72877768A | 1968-05-13 | 1968-05-13 | |
| US81517569A | 1969-04-10 | 1969-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1244277A true GB1244277A (en) | 1971-08-25 |
Family
ID=27111741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB24140/69A Expired GB1244277A (en) | 1968-05-13 | 1969-05-12 | Isolation of orgotein from blood |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT294315B (en) |
| BE (1) | BE732537A (en) |
| CH (1) | CH527227A (en) |
| DK (1) | DK132864C (en) |
| FR (1) | FR2008361A1 (en) |
| GB (1) | GB1244277A (en) |
| IL (1) | IL32097A (en) |
| NL (1) | NL6906952A (en) |
| SE (1) | SE375693B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0038393A1 (en) * | 1980-04-21 | 1981-10-28 | De Forenede Bryggerier A/S | Process for recovering enzymes from blood |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA924640A (en) * | 1970-01-16 | 1973-04-17 | Huber Wolfgang | Orgotein purification process |
| JPS5712993A (en) * | 1980-06-23 | 1982-01-22 | Fujirebio Inc | Isolation of superoxide dismutase |
-
1969
- 1969-04-29 IL IL32097A patent/IL32097A/en unknown
- 1969-05-05 BE BE732537D patent/BE732537A/xx not_active IP Right Cessation
- 1969-05-07 NL NL6906952A patent/NL6906952A/xx unknown
- 1969-05-09 FR FR6914931A patent/FR2008361A1/fr not_active Withdrawn
- 1969-05-12 SE SE6906714A patent/SE375693B/xx unknown
- 1969-05-12 DK DK256869A patent/DK132864C/en active
- 1969-05-12 AT AT455069A patent/AT294315B/en not_active IP Right Cessation
- 1969-05-12 GB GB24140/69A patent/GB1244277A/en not_active Expired
- 1969-05-13 CH CH739969A patent/CH527227A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0038393A1 (en) * | 1980-04-21 | 1981-10-28 | De Forenede Bryggerier A/S | Process for recovering enzymes from blood |
Also Published As
| Publication number | Publication date |
|---|---|
| BE732537A (en) | 1969-11-05 |
| CH527227A (en) | 1972-08-31 |
| NL6906952A (en) | 1969-11-17 |
| DE1924230A1 (en) | 1970-07-02 |
| AT294315B (en) | 1971-11-25 |
| IL32097A0 (en) | 1969-06-25 |
| FR2008361A1 (en) | 1970-01-23 |
| DK132864B (en) | 1976-02-23 |
| IL32097A (en) | 1973-08-29 |
| SE375693B (en) | 1975-04-28 |
| DK132864C (en) | 1976-07-19 |
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