GB1244201A - Derivatives of (-) (cis-1,2-epoxypropyl)phosphonic acid - Google Patents
Derivatives of (-) (cis-1,2-epoxypropyl)phosphonic acidInfo
- Publication number
- GB1244201A GB1244201A GB50632/68A GB5063268A GB1244201A GB 1244201 A GB1244201 A GB 1244201A GB 50632/68 A GB50632/68 A GB 50632/68A GB 5063268 A GB5063268 A GB 5063268A GB 1244201 A GB1244201 A GB 1244201A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- sept
- phosphonic acid
- halogen
- phenylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- -1 cyclic amine Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 230000002421 anti-septic effect Effects 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940064004 antiseptic throat preparations Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229960002950 novobiocin Drugs 0.000 abstract 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 229960005322 streptomycin Drugs 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paints Or Removers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
1,244,201. Antiseptics containing phosphonic acid derivatives. MERCK & CO. Inc. 24 Oct., 1968 [6 Sept., 1968; 18 Sept., 1968], No. 50632/68. Headings A5B and ASE. [Also in Division C2] A pharmaceutic composition comprises a pharmaceutically acceptable vehicle and a compound of the formula wherein each of X and Y is an OR, SR or NR, R 2 group or a halogen atom wherein R is H or a substituted or unsubstiuted hydrocarbyl or heterocyclic radical and each of R 1 and R 2 is as defined for R, or NR, R 2 is a residue of a cyclic amine with the proviso that X and Y are not both OR or both halogen atoms and that one of X and Y is not OR when the other is halogen, each of R 6 and R 7 is H, a C 1 -C 6 alkyl, aralkyl, substituted aralkyl, aryl, C 2 -C 6 -alkenyl or -alkynyl, cycloalkyl, cycloalkenyl, or heteroaryl group and R 8 is phenylene or substituted phenylene or a polymethylene group containing 2 to 4 CH 2 radicals, or an organic or inorganic salt of such compounds in which one of X and Y is OH or SH. The composition may be in the form of a tablet, capsule or pill, solution or suspension or in injectable form with a sterile isotonic liquid diluent. The defined phosphorus compound may also be used as active ingredients in antiseptic compositions containing a diluent or carrier. When the products are used pharmaceutically they may be admixed with other antibacterial agents such as penicillin, streptomycin or novobiocin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75814968A | 1968-09-06 | 1968-09-06 | |
| US76068468A | 1968-09-18 | 1968-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1244201A true GB1244201A (en) | 1971-08-25 |
Family
ID=27116497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50632/68A Expired GB1244201A (en) | 1968-09-06 | 1968-10-24 | Derivatives of (-) (cis-1,2-epoxypropyl)phosphonic acid |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS4816906B1 (en) |
| BE (1) | BE723080A (en) |
| CH (1) | CH546260A (en) |
| ES (4) | ES359544A1 (en) |
| GB (1) | GB1244201A (en) |
| IE (1) | IE32527B1 (en) |
| IL (1) | IL30912A0 (en) |
| IT (1) | IT969021B (en) |
| LU (1) | LU57191A1 (en) |
| NL (1) | NL6814987A (en) |
| OA (1) | OA04039A (en) |
| RO (1) | RO54801A (en) |
| SE (1) | SE363338B (en) |
| ZM (1) | ZM14568A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2017516B1 (en) * | 1968-09-06 | 1973-01-12 | Merck & Co Inc |
-
1968
- 1968-10-18 NL NL6814987A patent/NL6814987A/xx unknown
- 1968-10-21 IL IL30912A patent/IL30912A0/en unknown
- 1968-10-22 IE IE1265/68A patent/IE32527B1/en unknown
- 1968-10-24 GB GB50632/68A patent/GB1244201A/en not_active Expired
- 1968-10-24 CH CH1592768A patent/CH546260A/en not_active IP Right Cessation
- 1968-10-25 IT IT40727/68A patent/IT969021B/en active
- 1968-10-25 ES ES359544A patent/ES359544A1/en not_active Expired
- 1968-10-29 BE BE723080D patent/BE723080A/xx unknown
- 1968-10-29 LU LU57191D patent/LU57191A1/xx unknown
- 1968-10-29 SE SE14623/68A patent/SE363338B/xx unknown
- 1968-10-30 OA OA53405A patent/OA04039A/en unknown
- 1968-10-30 JP JP43078611A patent/JPS4816906B1/ja active Pending
- 1968-10-30 ZM ZM145/68A patent/ZM14568A1/en unknown
- 1968-11-19 RO RO58236A patent/RO54801A/ro unknown
-
1970
- 1970-03-16 ES ES377582A patent/ES377582A1/en not_active Expired
- 1970-03-16 ES ES377580A patent/ES377580A1/en not_active Expired
- 1970-03-16 ES ES377581A patent/ES377581A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE363338B (en) | 1974-01-14 |
| ES359544A1 (en) | 1970-08-16 |
| ES377582A1 (en) | 1973-02-01 |
| IE32527L (en) | 1970-03-06 |
| DE1805686A1 (en) | 1970-06-25 |
| OA04039A (en) | 1979-10-15 |
| RO54801A (en) | 1973-04-12 |
| CH546260A (en) | 1974-02-28 |
| IE32527B1 (en) | 1973-09-05 |
| ES377581A1 (en) | 1973-02-01 |
| NL6814987A (en) | 1970-03-10 |
| JPS4816906B1 (en) | 1973-05-25 |
| IT969021B (en) | 1974-03-30 |
| ES377580A1 (en) | 1972-08-16 |
| BE723080A (en) | 1969-04-29 |
| LU57191A1 (en) | 1969-05-16 |
| IL30912A0 (en) | 1968-12-26 |
| ZM14568A1 (en) | 1970-06-18 |
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