GB1193302A - 7-Aminocephalosporanic Acid Derivatives - Google Patents
7-Aminocephalosporanic Acid DerivativesInfo
- Publication number
- GB1193302A GB1193302A GB1061267A GB1061267A GB1193302A GB 1193302 A GB1193302 A GB 1193302A GB 1061267 A GB1061267 A GB 1061267A GB 1061267 A GB1061267 A GB 1061267A GB 1193302 A GB1193302 A GB 1193302A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- group
- cephalosporanate
- thienylacetamido
- cephalosporins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 229940124587 cephalosporin Drugs 0.000 abstract 3
- 150000001780 cephalosporins Chemical class 0.000 abstract 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- -1 α - carboxyphenylacetamido Chemical group 0.000 abstract 2
- ARXOEMKPQNUWII-WTNGLUPJSA-N (6R)-7-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-8-oxo-3-(pyridin-2-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound C(=O)(O)C(C(=O)NC1[C@@H]2N(C(=C(CS2)CC2=NC=CC=C2)C(=O)O)C1=O)C1=CSC=C1 ARXOEMKPQNUWII-WTNGLUPJSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 108010019160 Pancreatin Proteins 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 108010027597 alpha-chymotrypsin Proteins 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002596 lactones Chemical group 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229940055695 pancreatin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- 229960004919 procaine Drugs 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1061267A GB1193302A (en) | 1967-03-07 | 1967-03-07 | 7-Aminocephalosporanic Acid Derivatives |
| DE19681670320 DE1670320A1 (de) | 1967-03-07 | 1968-02-29 | 7-Aminocephalosporan-Verbindungen und Verfahren zu ihrer Herstellung |
| NL6802902A NL6802902A (enrdf_load_stackoverflow) | 1967-03-07 | 1968-02-29 | |
| BE711649D BE711649A (enrdf_load_stackoverflow) | 1967-03-07 | 1968-03-04 | |
| CH323068A CH498865A (de) | 1967-03-07 | 1968-03-05 | Verfahren zur Herstellung von Derivaten der 7-Aminocephalosporansäure |
| FR142515A FR7545M (enrdf_load_stackoverflow) | 1967-03-07 | 1968-03-06 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1061267A GB1193302A (en) | 1967-03-07 | 1967-03-07 | 7-Aminocephalosporanic Acid Derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1193302A true GB1193302A (en) | 1970-05-28 |
Family
ID=9971083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1061267A Expired GB1193302A (en) | 1967-03-07 | 1967-03-07 | 7-Aminocephalosporanic Acid Derivatives |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE711649A (enrdf_load_stackoverflow) |
| CH (1) | CH498865A (enrdf_load_stackoverflow) |
| DE (1) | DE1670320A1 (enrdf_load_stackoverflow) |
| FR (1) | FR7545M (enrdf_load_stackoverflow) |
| GB (1) | GB1193302A (enrdf_load_stackoverflow) |
| NL (1) | NL6802902A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU168914B (enrdf_load_stackoverflow) * | 1974-07-30 | 1976-08-28 |
-
1967
- 1967-03-07 GB GB1061267A patent/GB1193302A/en not_active Expired
-
1968
- 1968-02-29 NL NL6802902A patent/NL6802902A/xx unknown
- 1968-02-29 DE DE19681670320 patent/DE1670320A1/de active Pending
- 1968-03-04 BE BE711649D patent/BE711649A/xx not_active IP Right Cessation
- 1968-03-05 CH CH323068A patent/CH498865A/de not_active IP Right Cessation
- 1968-03-06 FR FR142515A patent/FR7545M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1670320A1 (de) | 1971-02-25 |
| FR7545M (enrdf_load_stackoverflow) | 1969-12-29 |
| BE711649A (enrdf_load_stackoverflow) | 1968-09-04 |
| CH498865A (de) | 1970-11-15 |
| NL6802902A (enrdf_load_stackoverflow) | 1968-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |