GB1182124A - Process for the production of Pharmaceutical and like Beadlets - Google Patents

Process for the production of Pharmaceutical and like Beadlets

Info

Publication number
GB1182124A
GB1182124A GB20981/67A GB2098167A GB1182124A GB 1182124 A GB1182124 A GB 1182124A GB 20981/67 A GB20981/67 A GB 20981/67A GB 2098167 A GB2098167 A GB 2098167A GB 1182124 A GB1182124 A GB 1182124A
Authority
GB
United Kingdom
Prior art keywords
aluminium
solvent
bed
polymer
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20981/67A
Inventor
William Eric Gaunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL131321D priority Critical patent/NL131321C/xx
Priority to FR104134A priority patent/FR6327M/fr
Priority to DE19671667062 priority patent/DE1667062A1/en
Application filed by Individual filed Critical Individual
Priority to NL6706319A priority patent/NL6706319A/xx
Priority to GB20981/67A priority patent/GB1182124A/en
Publication of GB1182124A publication Critical patent/GB1182124A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

1,182,124. Pharmaceutical &c. beadlets. W. E. GAUNT. 5 May, 1967, No. 20981/67. Headings A5B and A5E. Small, spherical beads of substantially identical size and composition and containing at least one pharmaceutically or biochemically active ingredient are prepared by allowing drops of a solvent or solvent mixture to fall on a bed of finely divided polymer which is readily soluble in the solvent. The spherical beads formed are screened out of the bed subsequently and dried. Specified polymers are: cellulose acetate phthalate, carboxy polymethylene and carboxylated polyvinyl acetate co-polymers. The active compound, which may be present in the solvent or the polymer bed, may be a medicament such as a tranquilizer, antihistamine, steroid, anorectic, antibiotic, decongestant, antitussive, antichlorinergic, antibacterial or antifungal agent many examples of which are specified. Alternatively, it may be an agricultural chemical such as a herbicide e.g. phenyl mercuric acetate. The polymer bed may also contain a "cosubstance" which becomes entrapped in the beads and modifies their properties (particularly rate of release of the active substance). The "cosubstances" used are film-forming aluminium salts. When the active ingredient forms such an aluminium salt, this salt is used; when it is not, aluminium aspirin is used. Other aluminium salts mentioned are aluminium abietate, naphthenate and octoate.
GB20981/67A 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets Expired GB1182124A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
NL131321D NL131321C (en) 1967-05-05
FR104134A FR6327M (en) 1967-05-05 1967-04-25
DE19671667062 DE1667062A1 (en) 1967-05-05 1967-04-28 Process for the production of small spherical beads
NL6706319A NL6706319A (en) 1967-05-05 1967-05-05
GB20981/67A GB1182124A (en) 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB20981/67A GB1182124A (en) 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets

Publications (1)

Publication Number Publication Date
GB1182124A true GB1182124A (en) 1970-02-25

Family

ID=10155145

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20981/67A Expired GB1182124A (en) 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets

Country Status (4)

Country Link
DE (1) DE1667062A1 (en)
FR (1) FR6327M (en)
GB (1) GB1182124A (en)
NL (2) NL6706319A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086704A1 (en) * 1982-02-15 1983-08-24 MICROENCAPSULATION S.A. Société dite: Process and apparatus for the production of perfectly spherical and porous granules, and granules produced in this way
US4642233A (en) * 1982-03-22 1987-02-10 Alza Corporation Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills
US4649043A (en) * 1982-03-22 1987-03-10 Alza Corporation Drug delivery system for delivering a plurality of tiny pills in the gastrointestinal tract
US4659558A (en) * 1982-03-22 1987-04-21 Alza Corporation Oral delivery system comprising a plurality of tiny pills for delivering drug in the stomach and intestine
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US9974752B2 (en) 2014-10-31 2018-05-22 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086704A1 (en) * 1982-02-15 1983-08-24 MICROENCAPSULATION S.A. Société dite: Process and apparatus for the production of perfectly spherical and porous granules, and granules produced in this way
US4642233A (en) * 1982-03-22 1987-02-10 Alza Corporation Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills
US4649043A (en) * 1982-03-22 1987-03-10 Alza Corporation Drug delivery system for delivering a plurality of tiny pills in the gastrointestinal tract
US4659558A (en) * 1982-03-22 1987-04-21 Alza Corporation Oral delivery system comprising a plurality of tiny pills for delivering drug in the stomach and intestine
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5296232A (en) * 1989-05-05 1994-03-22 Kv Pharmaceutical Company Pharmaceutical formulation which does not induce tolerance
US5445829A (en) * 1989-05-05 1995-08-29 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US9974752B2 (en) 2014-10-31 2018-05-22 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10111839B2 (en) 2014-10-31 2018-10-30 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10292938B2 (en) 2014-10-31 2019-05-21 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10292939B2 (en) 2014-10-31 2019-05-21 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10449159B2 (en) 2014-10-31 2019-10-22 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10500162B2 (en) 2014-10-31 2019-12-10 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10507186B2 (en) 2014-10-31 2019-12-17 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10512612B2 (en) 2014-10-31 2019-12-24 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10512613B2 (en) 2014-10-31 2019-12-24 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10568841B2 (en) 2014-10-31 2020-02-25 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10688060B2 (en) 2014-10-31 2020-06-23 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US11896722B2 (en) 2014-10-31 2024-02-13 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Also Published As

Publication number Publication date
FR6327M (en) 1968-09-23
NL6706319A (en) 1968-11-06
NL131321C (en)
DE1667062A1 (en) 1971-06-03

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