GB1182124A - Process for the production of Pharmaceutical and like Beadlets - Google Patents

Process for the production of Pharmaceutical and like Beadlets

Info

Publication number
GB1182124A
GB1182124A GB2098167A GB2098167A GB1182124A GB 1182124 A GB1182124 A GB 1182124A GB 2098167 A GB2098167 A GB 2098167A GB 2098167 A GB2098167 A GB 2098167A GB 1182124 A GB1182124 A GB 1182124A
Authority
GB
United Kingdom
Prior art keywords
aluminium
solvent
bed
used
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2098167A
Inventor
William Eric Gaunt
Original Assignee
William Eric Gaunt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Eric Gaunt filed Critical William Eric Gaunt
Priority to GB2098167A priority Critical patent/GB1182124A/en
Publication of GB1182124A publication Critical patent/GB1182124A/en
Application status is Expired legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Abstract

1,182,124. Pharmaceutical &c. beadlets. W. E. GAUNT. 5 May, 1967, No. 20981/67. Headings A5B and A5E. Small, spherical beads of substantially identical size and composition and containing at least one pharmaceutically or biochemically active ingredient are prepared by allowing drops of a solvent or solvent mixture to fall on a bed of finely divided polymer which is readily soluble in the solvent. The spherical beads formed are screened out of the bed subsequently and dried. Specified polymers are: cellulose acetate phthalate, carboxy polymethylene and carboxylated polyvinyl acetate co-polymers. The active compound, which may be present in the solvent or the polymer bed, may be a medicament such as a tranquilizer, antihistamine, steroid, anorectic, antibiotic, decongestant, antitussive, antichlorinergic, antibacterial or antifungal agent many examples of which are specified. Alternatively, it may be an agricultural chemical such as a herbicide e.g. phenyl mercuric acetate. The polymer bed may also contain a "cosubstance" which becomes entrapped in the beads and modifies their properties (particularly rate of release of the active substance). The "cosubstances" used are film-forming aluminium salts. When the active ingredient forms such an aluminium salt, this salt is used; when it is not, aluminium aspirin is used. Other aluminium salts mentioned are aluminium abietate, naphthenate and octoate.
GB2098167A 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets Expired GB1182124A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2098167A GB1182124A (en) 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL131321D NL131321C (en) 1967-05-05
FR6327D FR6327M (en) 1967-05-05 1967-04-25
DE19671667062 DE1667062A1 (en) 1967-05-05 1967-04-28 A process for the production of small beads kugelfoermiger
NL6706319A NL6706319A (en) 1967-05-05 1967-05-05
GB2098167A GB1182124A (en) 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets

Publications (1)

Publication Number Publication Date
GB1182124A true GB1182124A (en) 1970-02-25

Family

ID=10155145

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2098167A Expired GB1182124A (en) 1967-05-05 1967-05-05 Process for the production of Pharmaceutical and like Beadlets

Country Status (4)

Country Link
DE (1) DE1667062A1 (en)
FR (1) FR6327M (en)
GB (1) GB1182124A (en)
NL (2) NL6706319A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086704A1 (en) * 1982-02-15 1983-08-24 MICROENCAPSULATION S.A. Société dite: Process and apparatus for the production of perfectly spherical and porous granules, and granules produced in this way
US4642233A (en) * 1982-03-22 1987-02-10 Alza Corporation Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills
US4649043A (en) * 1982-03-22 1987-03-10 Alza Corporation Drug delivery system for delivering a plurality of tiny pills in the gastrointestinal tract
US4659558A (en) * 1982-03-22 1987-04-21 Alza Corporation Oral delivery system comprising a plurality of tiny pills for delivering drug in the stomach and intestine
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US9974752B2 (en) 2014-10-31 2018-05-22 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086704A1 (en) * 1982-02-15 1983-08-24 MICROENCAPSULATION S.A. Société dite: Process and apparatus for the production of perfectly spherical and porous granules, and granules produced in this way
US4642233A (en) * 1982-03-22 1987-02-10 Alza Corporation Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills
US4649043A (en) * 1982-03-22 1987-03-10 Alza Corporation Drug delivery system for delivering a plurality of tiny pills in the gastrointestinal tract
US4659558A (en) * 1982-03-22 1987-04-21 Alza Corporation Oral delivery system comprising a plurality of tiny pills for delivering drug in the stomach and intestine
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5296232A (en) * 1989-05-05 1994-03-22 Kv Pharmaceutical Company Pharmaceutical formulation which does not induce tolerance
US5445829A (en) * 1989-05-05 1995-08-29 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US9974752B2 (en) 2014-10-31 2018-05-22 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10111839B2 (en) 2014-10-31 2018-10-30 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10292939B2 (en) 2014-10-31 2019-05-21 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US10292938B2 (en) 2014-10-31 2019-05-21 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Also Published As

Publication number Publication date
NL131321C (en)
DE1667062A1 (en) 1971-06-03
NL6706319A (en) 1968-11-06
FR6327M (en) 1968-09-23

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