GB1181571A - Novel 1,4-Benzoxazepine and 1,4-Benzothiazepine Derivatives and Processes for the Preparation Thereof - Google Patents
Novel 1,4-Benzoxazepine and 1,4-Benzothiazepine Derivatives and Processes for the Preparation ThereofInfo
- Publication number
- GB1181571A GB1181571A GB9508/67A GB950867A GB1181571A GB 1181571 A GB1181571 A GB 1181571A GB 9508/67 A GB9508/67 A GB 9508/67A GB 950867 A GB950867 A GB 950867A GB 1181571 A GB1181571 A GB 1181571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- general formula
- compound
- thia
- benzoxazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KYVHGCKMVJDCNV-UHFFFAOYSA-N 1,4-benzothiazepine Chemical class S1C=CN=CC2=CC=CC=C12 KYVHGCKMVJDCNV-UHFFFAOYSA-N 0.000 title abstract 4
- UWXIKAZQXAYFPT-UHFFFAOYSA-N 1,4-benzoxazepine Chemical compound O1C=CN=CC2=CC=CC=C12 UWXIKAZQXAYFPT-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 241000534944 Thia Species 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- 125000001174 sulfone group Chemical group 0.000 abstract 2
- 125000003903 2-propenyl group Chemical class [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical class [H]C#CC([H])([H])* 0.000 abstract 1
- -1 2-substituted benzoic acid Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000490 cinnamyl group Chemical class C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical class CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 150000002828 nitro derivatives Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940103494 thiosalicylic acid Drugs 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53326466A | 1966-03-10 | 1966-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1181571A true GB1181571A (en) | 1970-02-18 |
Family
ID=24125202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9508/67A Expired GB1181571A (en) | 1966-03-10 | 1967-02-28 | Novel 1,4-Benzoxazepine and 1,4-Benzothiazepine Derivatives and Processes for the Preparation Thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3794639A (https=) |
| BE (1) | BE695313A (https=) |
| CH (1) | CH482706A (https=) |
| DE (1) | DE1695698A1 (https=) |
| FR (2) | FR1602881A (https=) |
| GB (1) | GB1181571A (https=) |
| NL (1) | NL6703347A (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0175570A3 (en) * | 1984-09-19 | 1988-07-20 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Process for the preparation of aromatic-1,4-oxazepinones and thiones |
| WO1994018184A1 (en) * | 1993-02-15 | 1994-08-18 | The Wellcome Foundation Limited | Hypolipidaemic compounds |
| WO2001000185A3 (en) * | 1999-06-24 | 2002-04-11 | Knoll Gmbh | 1,4-denzothiazepines to treat obesity related disorders |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE761315A (https=) * | 1970-01-12 | 1971-07-07 | S M B Anciens Etablissements J | |
| US4125538A (en) * | 1977-02-04 | 1978-11-14 | Bristol-Myers Company | Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines |
| US4318909A (en) * | 1980-01-17 | 1982-03-09 | John Wyeth & Brother Limited | Benzoxazocines |
| US4626522A (en) * | 1980-01-17 | 1986-12-02 | John Wyeth & Brother Limited | Benzoxazocines intermediates |
| ZA836995B (en) * | 1982-09-30 | 1984-05-30 | Robins Co Inc A H | Fused arpmatic oxazepinones and sulfur analogs thereof in a method of counteracting histamine |
| EP0376633B1 (en) * | 1988-12-28 | 1994-10-12 | Suntory Limited | Benzoxazepine derivatives |
| JP2703408B2 (ja) | 1990-12-28 | 1998-01-26 | 麒麟麦酒株式会社 | １，４‐ベンゾチアゼピン誘導体 |
| EP1907183A4 (en) * | 2005-06-30 | 2009-11-11 | Stc Consulting Llc | METHOD AND APPARATUS FOR THE CRYOGENIC TREATMENT OF LESIONS ON BIOLOGICAL TISSUE |
-
1966
- 1966-03-10 US US00533264A patent/US3794639A/en not_active Expired - Lifetime
-
1967
- 1967-02-28 GB GB9508/67A patent/GB1181571A/en not_active Expired
- 1967-02-28 NL NL6703347A patent/NL6703347A/xx unknown
- 1967-03-08 DE DE19671695698 patent/DE1695698A1/de active Pending
- 1967-03-09 CH CH346467A patent/CH482706A/fr not_active IP Right Cessation
- 1967-03-10 FR FR1602881D patent/FR1602881A/fr not_active Expired
- 1967-03-10 BE BE695313D patent/BE695313A/xx unknown
- 1967-06-09 FR FR109727A patent/FR7504M/fr not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0175570A3 (en) * | 1984-09-19 | 1988-07-20 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Process for the preparation of aromatic-1,4-oxazepinones and thiones |
| WO1994018184A1 (en) * | 1993-02-15 | 1994-08-18 | The Wellcome Foundation Limited | Hypolipidaemic compounds |
| JP2886341B2 (ja) | 1993-02-15 | 1999-04-26 | ザ・ウエルカム・ファウンデーション・リミテッド | 低脂血症化合物 |
| WO2001000185A3 (en) * | 1999-06-24 | 2002-04-11 | Knoll Gmbh | 1,4-denzothiazepines to treat obesity related disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6703347A (https=) | 1967-09-11 |
| CH482706A (fr) | 1969-12-15 |
| FR1602881A (https=) | 1971-02-08 |
| DE1695698A1 (de) | 1971-04-29 |
| BE695313A (https=) | 1967-09-11 |
| FR7504M (https=) | 1969-12-08 |
| US3794639A (en) | 1974-02-26 |
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