GB1180574A - Improvements in or relating to Injectable Thyroxine Preparations - Google Patents
Improvements in or relating to Injectable Thyroxine PreparationsInfo
- Publication number
- GB1180574A GB1180574A GB6626/67A GB662667A GB1180574A GB 1180574 A GB1180574 A GB 1180574A GB 6626/67 A GB6626/67 A GB 6626/67A GB 662667 A GB662667 A GB 662667A GB 1180574 A GB1180574 A GB 1180574A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thyroxine
- injectable
- preparations
- relating
- feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 title abstract 5
- 229940034208 thyroxine Drugs 0.000 title abstract 5
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229960004494 calcium gluconate Drugs 0.000 abstract 2
- 235000013927 calcium gluconate Nutrition 0.000 abstract 2
- 239000004227 calcium gluconate Substances 0.000 abstract 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 abstract 2
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940045999 vitamin b 12 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,180,574. Injectable thyroxine preparations. M. ISRAEL. 10 Feb., 1967 [18 Feb., 1966], No. 6626/67. Heading A5B. An injectable aqueous pharmaceutical composition comprises thyroxine as the active ingredient together with calcium gluconate and a macroanionic complex of vitamin B 12 and gelatin, there being present at least five times the weight of thyroxine of the complex and at least twenty times the weight of thyroxine of calcium gluconate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX8720666 | 1966-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1180574A true GB1180574A (en) | 1970-02-04 |
Family
ID=19743118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6626/67A Expired GB1180574A (en) | 1966-02-18 | 1967-02-10 | Improvements in or relating to Injectable Thyroxine Preparations |
Country Status (4)
| Country | Link |
|---|---|
| BR (1) | BR6787100D0 (en) |
| DE (1) | DE1617540A1 (en) |
| FR (1) | FR6191M (en) |
| GB (1) | GB1180574A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236855A1 (en) * | 1986-03-06 | 1987-09-16 | MERCK PATENT GmbH | Pharmaceutical composition |
| WO1999059551A1 (en) * | 1998-05-15 | 1999-11-25 | Merck Patent Gmbh | Pharmaceutical preparation containing levothyroxine sodium |
| EP1433478A1 (en) * | 2002-12-27 | 2004-06-30 | Altergon S.A. | Pharmaceutical formulae for thyroid hormones and procedures for obtaining them |
-
1967
- 1967-02-01 FR FR93308A patent/FR6191M/fr not_active Expired
- 1967-02-04 DE DE19671617540 patent/DE1617540A1/en active Pending
- 1967-02-10 GB GB6626/67A patent/GB1180574A/en not_active Expired
- 1967-02-17 BR BR18710067A patent/BR6787100D0/en unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236855A1 (en) * | 1986-03-06 | 1987-09-16 | MERCK PATENT GmbH | Pharmaceutical composition |
| WO1999059551A1 (en) * | 1998-05-15 | 1999-11-25 | Merck Patent Gmbh | Pharmaceutical preparation containing levothyroxine sodium |
| JP2002515421A (en) * | 1998-05-15 | 2002-05-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Pharmaceutical preparations containing levothyroxine sodium |
| EP1077681B1 (en) * | 1998-05-15 | 2002-10-09 | MERCK PATENT GmbH | Pharmaceutical preparation containing levothyroxine sodium |
| US6646007B1 (en) | 1998-05-15 | 2003-11-11 | Merck Patent Gmbh | Process for preparing a pharmaceutical formulation containing levothyroxine sodium |
| US8008349B2 (en) | 1998-05-15 | 2011-08-30 | Merck Patent Gmbh | Stable pharmaceutical preparation comprising levothyroxine sodium, gelatin and fillers and which is free of organic solvent residues |
| EP1433478A1 (en) * | 2002-12-27 | 2004-06-30 | Altergon S.A. | Pharmaceutical formulae for thyroid hormones and procedures for obtaining them |
| US7691411B2 (en) | 2002-12-27 | 2010-04-06 | Altergon S.A. | Pharmaceutical formulae for thyroid hormones and procedures for obtaining them |
Also Published As
| Publication number | Publication date |
|---|---|
| BR6787100D0 (en) | 1973-05-24 |
| DE1617540A1 (en) | 1971-04-08 |
| FR6191M (en) | 1968-07-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1135047A (en) | Improvements in or relating to combine harvesters | |
| IL38438A (en) | Phosphorothiolates,their preparation and their use as pesticides | |
| FI51476C (en) | A process for the preparation of biologically active prostaglandin F1 and its derivatives. | |
| IL36756A0 (en) | Carbamoyl-and thiocarbamoyl-guanidines,their preparation and use as plant growth regulants | |
| GB1403900A (en) | Pharmaceutical composition | |
| IL30585A0 (en) | 1,2,4-thiadiazolyl ureas,their preparation and use as herbicides | |
| GB1178341A (en) | Phenylnaphthoic Acid Lactones as Fish-Killing Substances | |
| GB1180574A (en) | Improvements in or relating to Injectable Thyroxine Preparations | |
| GB1180123A (en) | Improvements in or relating to Crop Stores. | |
| IL34878A (en) | Hydrochloride and hydrobromide acid addition salts of n-carboxy-arginine anhydride and n-carboxy histidine-anhydride,and their preparation | |
| IL37477A (en) | 1,1-diphenyl-2-nitropropanes,their preparation and use as insecticides | |
| GB1218648A (en) | Improvements in hay rolls | |
| GB1051686A (en) | ||
| IL32661A0 (en) | Benzofuran-2-carboxylic acid derivatives,their preparation and pharmaceutical preparations containing them | |
| GB1327560A (en) | Effervescent pharmaceutical preparations | |
| IL37121A (en) | 1-carbamoyl-n-carbamoyloxy formimidates and their derivatives,their preparation and their use as pesticides | |
| GB1220818A (en) | New medicinal composition | |
| GB1250598A (en) | ||
| GB1196986A (en) | Fumigating Composition | |
| IL36708A (en) | 1,2,4-thiadiazolyl derivatives,their preparation and their use as herbicides | |
| GB1159174A (en) | Pharmaceutical Compositions | |
| GB1247295A (en) | Improvements in or relating to chairs | |
| CA751914A (en) | 2,2'-oxodisuccinic acid and derivatives thereof | |
| GB1043133A (en) | Improvements in or relating to haymaking machines | |
| AU411023B2 (en) | 2,4,6-triodoisophthalic acid derivatives and preparation thereof |