GB1179546A - 01-Oxygenated-12alpha-Halo-16alpha-Methyl-Pregnenes - Google Patents
01-Oxygenated-12alpha-Halo-16alpha-Methyl-PregnenesInfo
- Publication number
- GB1179546A GB1179546A GB2956069A GB2956069A GB1179546A GB 1179546 A GB1179546 A GB 1179546A GB 2956069 A GB2956069 A GB 2956069A GB 2956069 A GB2956069 A GB 2956069A GB 1179546 A GB1179546 A GB 1179546A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- pregnenes
- oxygenated
- halo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,179,546. 11 - Oxygenated - 12α - halo - 16α - methyl-pregnenes. E. R. SQUIBB & SONS Inc. 13 Dec., 1966 [22 Dec., 1965], No. 29560/69. Divided out of 1,174,780. Heading C2U. The invention comprises compounds of formula wherein X is Cl, F or Br, R is H, R<SP>1</SP> is OH, or R and R<SP>1</SP> are together oxo, and Z is H, OH or acyloxy, and the corresponding #<SP>1</SP>'<SP>4</SP>,#<SP>4</SP>'<SP>6</SP> and #<SP>1,4,6</SP> compounds. The #<SP>4</SP>-compounds wherein X is Br, R is H and R<SP>1</SP> is OH (II) are prepared by dehydrohalogenation of the corresponding 4#,12α - dibromo - 5# - pregnanes, and are converted to the other 12-bromo compounds of Formula I by dehydrogenation and/or 11-oxidation. The #<SP>4</SP>-compounds, wherein X is Cl or F, are prepared from the compounds II via the corresponding 11#, 12#-oxido compounds, and are converted to other 12-chloro or fluoro compounds of Formula I by dehydrogenation and/or 11-oxidation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51574765A | 1965-12-22 | 1965-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1179546A true GB1179546A (en) | 1970-01-28 |
Family
ID=24052580
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55738/66A Expired GB1174780A (en) | 1965-12-22 | 1966-12-13 | 01beta-Hydroxy-12alpha-Bromo-16alpha-Methyl-5beta-Pregnanes |
| GB2987569A Expired GB1179547A (en) | 1965-12-22 | 1966-12-13 | 01beta,12beta-Oxido-16alpha-Methyl-Pregnenes |
| GB2956069A Expired GB1179546A (en) | 1965-12-22 | 1966-12-13 | 01-Oxygenated-12alpha-Halo-16alpha-Methyl-Pregnenes |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55738/66A Expired GB1174780A (en) | 1965-12-22 | 1966-12-13 | 01beta-Hydroxy-12alpha-Bromo-16alpha-Methyl-5beta-Pregnanes |
| GB2987569A Expired GB1179547A (en) | 1965-12-22 | 1966-12-13 | 01beta,12beta-Oxido-16alpha-Methyl-Pregnenes |
Country Status (6)
| Country | Link |
|---|---|
| BR (1) | BR6685572D0 (en) |
| CH (1) | CH481075A (en) |
| DE (1) | DE1593480A1 (en) |
| FR (2) | FR1506008A (en) |
| GB (3) | GB1174780A (en) |
| NL (1) | NL6617943A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2632678C2 (en) * | 1976-07-16 | 1986-02-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6α-Fluoro-12α-Halo-Corticoids and Process for Their Preparation |
-
1966
- 1966-12-13 GB GB55738/66A patent/GB1174780A/en not_active Expired
- 1966-12-13 GB GB2987569A patent/GB1179547A/en not_active Expired
- 1966-12-13 GB GB2956069A patent/GB1179546A/en not_active Expired
- 1966-12-21 BR BR18557266A patent/BR6685572D0/en unknown
- 1966-12-21 NL NL6617943A patent/NL6617943A/xx unknown
- 1966-12-22 CH CH1850866A patent/CH481075A/en not_active IP Right Cessation
- 1966-12-22 FR FR88569A patent/FR1506008A/en not_active Expired
- 1966-12-22 DE DE19661593480 patent/DE1593480A1/en active Pending
-
1967
- 1967-03-21 FR FR99664A patent/FR7021M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1174780A (en) | 1969-12-17 |
| NL6617943A (en) | 1967-06-23 |
| CH481075A (en) | 1969-11-15 |
| BR6685572D0 (en) | 1973-12-27 |
| DE1593480A1 (en) | 1970-10-22 |
| FR1506008A (en) | 1967-12-15 |
| FR7021M (en) | 1969-06-09 |
| GB1179547A (en) | 1970-01-28 |
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