GB1160212A - Process for the Manufacture of Steroid Keto-Aldehydes - Google Patents
Process for the Manufacture of Steroid Keto-AldehydesInfo
- Publication number
- GB1160212A GB1160212A GB244767A GB244767A GB1160212A GB 1160212 A GB1160212 A GB 1160212A GB 244767 A GB244767 A GB 244767A GB 244767 A GB244767 A GB 244767A GB 1160212 A GB1160212 A GB 1160212A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- manufacture
- jan
- formula
- carboxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1,160,212. Steroids. SCHERING A.G. 17 Jan., 1967 [27 Jan., 1966], No. 2447/67. Heading C2U. A process for the manufacture of a steroid containing a 20-aldehyde group and also at least one keto group comprises reacting a corresponding steroid containing a 20-carboxyl group in the presence of an inert solvent with carbonyl diimidazole and the 20-carboxyl imidazolide group in the resulting compound is selectively reduced to an aldehyde group by means of a compound of the formula in which X represents a C 1 -C 6 alkyl group; if desired in the novel resulting compound which may be of the formula in which R 1 and R 2 each represents H, C 1 -C 5 alkyl, acyl or together represent an alkylene group, any acyloxy group(s) is/are saponified and/or any ether group(s) or alkylene group is/ are eliminated, or any free hydroxy group(s) is/are acylated or etherified. The reduction may be effected with LiAZ (t-butyl-O) 3 H at room temperature in the absence of atmospheric oxygen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESC038384 | 1966-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1160212A true GB1160212A (en) | 1969-08-06 |
Family
ID=7434681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB244767A Expired GB1160212A (en) | 1966-01-27 | 1967-01-17 | Process for the Manufacture of Steroid Keto-Aldehydes |
Country Status (11)
| Country | Link |
|---|---|
| BE (1) | BE693274A (en) |
| CH (1) | CH484889A (en) |
| DE (1) | DE1593490A1 (en) |
| DK (1) | DK114407B (en) |
| ES (1) | ES336022A1 (en) |
| FI (1) | FI43074B (en) |
| FR (1) | FR1508947A (en) |
| GB (1) | GB1160212A (en) |
| IL (1) | IL27181A (en) |
| NL (1) | NL6701320A (en) |
| SE (1) | SE330886B (en) |
-
1966
- 1966-01-27 DE DE19661593490 patent/DE1593490A1/en active Pending
- 1966-12-29 IL IL2718166A patent/IL27181A/en unknown
-
1967
- 1967-01-16 CH CH58167A patent/CH484889A/en not_active IP Right Cessation
- 1967-01-17 DK DK27467A patent/DK114407B/en unknown
- 1967-01-17 GB GB244767A patent/GB1160212A/en not_active Expired
- 1967-01-24 ES ES0336022A patent/ES336022A1/en not_active Expired
- 1967-01-26 FR FR92557A patent/FR1508947A/en not_active Expired
- 1967-01-27 BE BE693274D patent/BE693274A/xx unknown
- 1967-01-27 FI FI24767A patent/FI43074B/fi active
- 1967-01-27 NL NL6701320A patent/NL6701320A/xx unknown
- 1967-01-27 SE SE124567A patent/SE330886B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE330886B (en) | 1970-12-07 |
| NL6701320A (en) | 1967-07-28 |
| CH484889A (en) | 1970-01-31 |
| DE1593490A1 (en) | 1970-10-22 |
| ES336022A1 (en) | 1967-12-16 |
| BE693274A (en) | 1967-07-27 |
| DK114407B (en) | 1969-06-30 |
| FR1508947A (en) | 1968-01-05 |
| IL27181A (en) | 1970-11-30 |
| FI43074B (en) | 1970-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |