GB1158399A - Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines - Google Patents

Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines

Info

Publication number
GB1158399A
GB1158399A GB2621167A GB2621167A GB1158399A GB 1158399 A GB1158399 A GB 1158399A GB 2621167 A GB2621167 A GB 2621167A GB 2621167 A GB2621167 A GB 2621167A GB 1158399 A GB1158399 A GB 1158399A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
pyrazinamido
pyrazinoyl
guanidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2621167A
Other languages
English (en)
Inventor
Peter Immanuel Pollak
Roger James Tull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1158399A publication Critical patent/GB1158399A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB2621167A 1966-08-25 1967-06-07 Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines Expired GB1158399A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57491066A 1966-08-25 1966-08-25

Publications (1)

Publication Number Publication Date
GB1158399A true GB1158399A (en) 1969-07-16

Family

ID=24298148

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2621167A Expired GB1158399A (en) 1966-08-25 1967-06-07 Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines

Country Status (6)

Country Link
BE (1) BE699436A (es)
CH (1) CH487167A (es)
DK (1) DK115846B (es)
ES (1) ES341322A1 (es)
GB (1) GB1158399A (es)
NL (1) NL6707564A (es)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017153A1 (en) * 1979-03-27 1980-10-15 Merck & Co. Inc. Novel pyrazinecarboxamides, processes for preparing and pharmaceutical compositions containing the same
EP0017152A1 (en) * 1979-03-27 1980-10-15 Merck & Co. Inc. Novel heterocyclic substituted pyrazinoylguanidines, processes for preparing and a pharmaceutical composition containing the same
WO2009074575A2 (en) * 2007-12-10 2009-06-18 Novartis Ag Organic compounds
US9586911B2 (en) 2013-12-13 2017-03-07 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds
US9593084B2 (en) 2012-12-17 2017-03-14 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9695134B2 (en) 2012-12-17 2017-07-04 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds
US10167266B2 (en) 2002-02-19 2019-01-01 Parion Sciences, Inc. Sodium channel blockers
US10752597B2 (en) 2011-06-27 2020-08-25 Parion Sciences, Inc. 3,5-diamino-6-chloro-N—(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017153A1 (en) * 1979-03-27 1980-10-15 Merck & Co. Inc. Novel pyrazinecarboxamides, processes for preparing and pharmaceutical compositions containing the same
EP0017152A1 (en) * 1979-03-27 1980-10-15 Merck & Co. Inc. Novel heterocyclic substituted pyrazinoylguanidines, processes for preparing and a pharmaceutical composition containing the same
US10167266B2 (en) 2002-02-19 2019-01-01 Parion Sciences, Inc. Sodium channel blockers
EP2520574A1 (en) * 2007-12-10 2012-11-07 Novartis AG Amiloride analogues substituted on the cyclic guanidine moiety as ENaC blockers for treating respiratory diseases
JP2011506386A (ja) * 2007-12-10 2011-03-03 ノバルティス アーゲー 有機化合物
US8039472B2 (en) 2007-12-10 2011-10-18 Novartis Ag Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel
WO2009074575A3 (en) * 2007-12-10 2009-08-13 Novartis Ag Organic compounds
EA017919B1 (ru) * 2007-12-10 2013-04-30 Новартис Аг Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
US8697687B2 (en) 2007-12-10 2014-04-15 Novartis Ag Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives
US9139586B2 (en) 2007-12-10 2015-09-22 Novartis Ag Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives
US9643983B2 (en) 2007-12-10 2017-05-09 Novartis Ag Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives
WO2009074575A2 (en) * 2007-12-10 2009-06-18 Novartis Ag Organic compounds
US11578042B2 (en) 2011-06-27 2023-02-14 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US10752597B2 (en) 2011-06-27 2020-08-25 Parion Sciences, Inc. 3,5-diamino-6-chloro-N—(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US10071970B2 (en) 2012-12-17 2018-09-11 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9695134B2 (en) 2012-12-17 2017-07-04 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds
US10246425B2 (en) 2012-12-17 2019-04-02 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
US9593084B2 (en) 2012-12-17 2017-03-14 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9957238B2 (en) 2013-12-13 2018-05-01 Parion Sciences, Inc. Arylalkyl-and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US10233158B2 (en) 2013-12-13 2019-03-19 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US9586911B2 (en) 2013-12-13 2017-03-07 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds

Also Published As

Publication number Publication date
CH487167A (de) 1970-03-15
NL6707564A (es) 1968-02-26
ES341322A1 (es) 1968-10-01
DK115846B (da) 1969-11-17
BE699436A (es) 1967-12-04

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees