GB1158030A - Preparation of Ascorbyl Phophate and its Salts - Google Patents

Preparation of Ascorbyl Phophate and its Salts

Info

Publication number
GB1158030A
GB1158030A GB4027967A GB4027967A GB1158030A GB 1158030 A GB1158030 A GB 1158030A GB 4027967 A GB4027967 A GB 4027967A GB 4027967 A GB4027967 A GB 4027967A GB 1158030 A GB1158030 A GB 1158030A
Authority
GB
United Kingdom
Prior art keywords
metal
acid
alkaline earth
ascorbyl phosphate
phosphoric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4027967A
Inventor
David Frederick Hinkley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1158030A publication Critical patent/GB1158030A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

Abstract

1,158,030. Ascorbic acid derivatives. MERCK & CO. Inc. 4 Sept., 1967 [13 Sept., 1966], No. 40279/67. Heading C2V. Ascorbic acid, or an alkali metal, alkaline earth metal or magnesium salt thereof, is reacted with a phosphorylating agent, and the reaction mixture quenched with water and then reacted with an alkali metal, alkaline earth metal or magnesium base to obtain ascorbyl phosphate or an alkali metal, alkaline earth metal or magnesium salt thereof. The amount of base used determines whether ascorbyl phosphate or the mono-, di- or -tri-metal salt is obtained. The mono- and di-metal salts also may be obtained by adding suitable amounts-of acid to the tri-metal salt or by adding suitable amounts of base to ascorbyl phosphate. The phosphorylating agent may be phosphoryl chloride or bromide, phosphoric acid, chloro- or bromo-phosphoric acid, dichloro-phosphoric acid, pyrophosphoryl chloride or bromide or polyphosphoric acid. Examples are given.
GB4027967A 1966-09-13 1967-09-04 Preparation of Ascorbyl Phophate and its Salts Expired GB1158030A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57898366A 1966-09-13 1966-09-13

Publications (1)

Publication Number Publication Date
GB1158030A true GB1158030A (en) 1969-07-09

Family

ID=24315123

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4027967A Expired GB1158030A (en) 1966-09-13 1967-09-04 Preparation of Ascorbyl Phophate and its Salts

Country Status (3)

Country Link
CH (1) CH490424A (en)
GB (1) GB1158030A (en)
NL (1) NL6711799A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210220A (en) * 1990-03-07 1993-05-11 Hoffmann-La Roche Inc. Method for preparing derivatives of ascorbic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210220A (en) * 1990-03-07 1993-05-11 Hoffmann-La Roche Inc. Method for preparing derivatives of ascorbic acid

Also Published As

Publication number Publication date
NL6711799A (en) 1968-03-14
DE1668404B2 (en) 1975-11-13
CH490424A (en) 1970-05-15
DE1668404A1 (en) 1971-07-15

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees