GB1142030A - Optically active substituted piperidine compounds - Google Patents
Optically active substituted piperidine compoundsInfo
- Publication number
- GB1142030A GB1142030A GB2366367A GB2366367A GB1142030A GB 1142030 A GB1142030 A GB 1142030A GB 2366367 A GB2366367 A GB 2366367A GB 2366367 A GB2366367 A GB 2366367A GB 1142030 A GB1142030 A GB 1142030A
- Authority
- GB
- United Kingdom
- Prior art keywords
- optically active
- phenyl
- treatment
- acid
- piperidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1,142,030. Optically active substituted piperidines. CIBA Ltd. 14 June, 1966, No. 23663/67. Divided out of 1,142,029. Heading C2C. Novel dextrorotatory and levorotatory substituted piperidines of the formula wherein R represents a hydrogen atom or a lower alkyl group and Ph 1 , Ph 2 and Ph 3 each represents a phenyl, lower alkyl-phenyl, lower alkoxy-phenyl or halo-phenyl group, and acid addition salts thereof are prepared by reaction of racemic N-unsubstituted piperidines and reactive esters of compounds of the corresponding formulµ separation of the resulting 1-substituted piperidines by treatment with an antipode of an optically active acid and isolation of one or both of the diastereoisomeric salts and liberation of the optically active base, e.g. by treatment with an alkaline agent, followed by optional conversion to a corresponding acid addition salt by treatment with an acid or with an ion exchange preparation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2366367A GB1142030A (en) | 1966-06-14 | 1966-06-14 | Optically active substituted piperidine compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2366367A GB1142030A (en) | 1966-06-14 | 1966-06-14 | Optically active substituted piperidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1142030A true GB1142030A (en) | 1969-02-05 |
Family
ID=10199288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2366367A Expired GB1142030A (en) | 1966-06-14 | 1966-06-14 | Optically active substituted piperidine compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1142030A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052383A (en) | 1974-10-30 | 1977-10-04 | Schering Corporation | N-diphenylalkyl-2-benzyl azacyclic compounds |
US4140780A (en) | 1975-10-24 | 1979-02-20 | Schering Corporation | Pharmaceutical compositions comprising N-diphenylalkyl-2-benzyl azacyclic compounds and methods for their use |
US4173566A (en) | 1974-10-30 | 1979-11-06 | Schering Corporation | 1-Benzhydryl-2-cyanoazetidine |
FR2546166A1 (en) * | 1983-05-19 | 1984-11-23 | Synthelabo | Enantiomers of erythro-2-(4-benzylpiperidino)-1-(4-hydroxy- or 4-benzyloxyphenyl)propanol, their preparation and their therapeutic application |
WO1991010651A1 (en) * | 1990-01-06 | 1991-07-25 | Pfizer Limited | Anticholinergic agents |
-
1966
- 1966-06-14 GB GB2366367A patent/GB1142030A/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052383A (en) | 1974-10-30 | 1977-10-04 | Schering Corporation | N-diphenylalkyl-2-benzyl azacyclic compounds |
US4173566A (en) | 1974-10-30 | 1979-11-06 | Schering Corporation | 1-Benzhydryl-2-cyanoazetidine |
US4140780A (en) | 1975-10-24 | 1979-02-20 | Schering Corporation | Pharmaceutical compositions comprising N-diphenylalkyl-2-benzyl azacyclic compounds and methods for their use |
FR2546166A1 (en) * | 1983-05-19 | 1984-11-23 | Synthelabo | Enantiomers of erythro-2-(4-benzylpiperidino)-1-(4-hydroxy- or 4-benzyloxyphenyl)propanol, their preparation and their therapeutic application |
WO1991010651A1 (en) * | 1990-01-06 | 1991-07-25 | Pfizer Limited | Anticholinergic agents |
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