GB1142030A - Optically active substituted piperidine compounds - Google Patents

Optically active substituted piperidine compounds

Info

Publication number
GB1142030A
GB1142030A GB2366367A GB2366367A GB1142030A GB 1142030 A GB1142030 A GB 1142030A GB 2366367 A GB2366367 A GB 2366367A GB 2366367 A GB2366367 A GB 2366367A GB 1142030 A GB1142030 A GB 1142030A
Authority
GB
United Kingdom
Prior art keywords
optically active
phenyl
treatment
acid
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2366367A
Inventor
Robert Paul Mull
Renat Herbert Mizzoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Priority to GB2366367A priority Critical patent/GB1142030A/en
Publication of GB1142030A publication Critical patent/GB1142030A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1,142,030. Optically active substituted piperidines. CIBA Ltd. 14 June, 1966, No. 23663/67. Divided out of 1,142,029. Heading C2C. Novel dextrorotatory and levorotatory substituted piperidines of the formula wherein R represents a hydrogen atom or a lower alkyl group and Ph 1 , Ph 2 and Ph 3 each represents a phenyl, lower alkyl-phenyl, lower alkoxy-phenyl or halo-phenyl group, and acid addition salts thereof are prepared by reaction of racemic N-unsubstituted piperidines and reactive esters of compounds of the corresponding formulµ separation of the resulting 1-substituted piperidines by treatment with an antipode of an optically active acid and isolation of one or both of the diastereoisomeric salts and liberation of the optically active base, e.g. by treatment with an alkaline agent, followed by optional conversion to a corresponding acid addition salt by treatment with an acid or with an ion exchange preparation.
GB2366367A 1966-06-14 1966-06-14 Optically active substituted piperidine compounds Expired GB1142030A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2366367A GB1142030A (en) 1966-06-14 1966-06-14 Optically active substituted piperidine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2366367A GB1142030A (en) 1966-06-14 1966-06-14 Optically active substituted piperidine compounds

Publications (1)

Publication Number Publication Date
GB1142030A true GB1142030A (en) 1969-02-05

Family

ID=10199288

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2366367A Expired GB1142030A (en) 1966-06-14 1966-06-14 Optically active substituted piperidine compounds

Country Status (1)

Country Link
GB (1) GB1142030A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052383A (en) 1974-10-30 1977-10-04 Schering Corporation N-diphenylalkyl-2-benzyl azacyclic compounds
US4140780A (en) 1975-10-24 1979-02-20 Schering Corporation Pharmaceutical compositions comprising N-diphenylalkyl-2-benzyl azacyclic compounds and methods for their use
US4173566A (en) 1974-10-30 1979-11-06 Schering Corporation 1-Benzhydryl-2-cyanoazetidine
FR2546166A1 (en) * 1983-05-19 1984-11-23 Synthelabo Enantiomers of erythro-2-(4-benzylpiperidino)-1-(4-hydroxy- or 4-benzyloxyphenyl)propanol, their preparation and their therapeutic application
WO1991010651A1 (en) * 1990-01-06 1991-07-25 Pfizer Limited Anticholinergic agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052383A (en) 1974-10-30 1977-10-04 Schering Corporation N-diphenylalkyl-2-benzyl azacyclic compounds
US4173566A (en) 1974-10-30 1979-11-06 Schering Corporation 1-Benzhydryl-2-cyanoazetidine
US4140780A (en) 1975-10-24 1979-02-20 Schering Corporation Pharmaceutical compositions comprising N-diphenylalkyl-2-benzyl azacyclic compounds and methods for their use
FR2546166A1 (en) * 1983-05-19 1984-11-23 Synthelabo Enantiomers of erythro-2-(4-benzylpiperidino)-1-(4-hydroxy- or 4-benzyloxyphenyl)propanol, their preparation and their therapeutic application
WO1991010651A1 (en) * 1990-01-06 1991-07-25 Pfizer Limited Anticholinergic agents

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