GB1141422A - Diuretics - Google Patents

Diuretics

Info

Publication number
GB1141422A
GB1141422A GB423167A GB423167A GB1141422A GB 1141422 A GB1141422 A GB 1141422A GB 423167 A GB423167 A GB 423167A GB 423167 A GB423167 A GB 423167A GB 1141422 A GB1141422 A GB 1141422A
Authority
GB
United Kingdom
Prior art keywords
acetic acid
phenoxy
guanidine
chloro
diuretic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB423167A
Inventor
Edward Jethro Cragoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to GB423167A priority Critical patent/GB1141422A/en
Publication of GB1141422A publication Critical patent/GB1141422A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine

Abstract

1,141,422. Diuretics. MERCK & CO. Inc. 27 Jan., 1967, No. 4231/67. Heading A5B. Excessive potassium excretion in non-human animals due to the administration of a therapeutic amount of a diuretic selected from:- (B1) [2,3 - dichloro - 4 - (2 - methylene butyryl) phenoxy] acetic acid, [3 - chloro - 4 - (2 - methylenebutyryl) phenoxy] acetic acid, [2,3 - dimethyl - 4 - (2 - methylenebutyryl) phenoxy] acetic acid, [2,3 - dichloro - 4 - (2 - ethylidenebutyryl) phenoxy] acetic acid, [4 - (2 - methylene butyryl) - 1 - naphthyloxy] acetic acid; (B2) hydrochlorothiazide, chlorothiazide, flumethiazide, benzthiazide, cyclopenthiazide, cyclothiazide, trichloromethiazide, 3- benzyl - 6 - trifluoromethyl - 7 - sulphamoyl - 2,3 - dihydro - 1,2,4, - benzothiazine - 1,1 - dioxide, hydroflumethiazide, methyclothiazide, quinethazone, polythiazide, 3 - isobutyl - 6 - chloro - 7 - sulphamoyl - 2, 3 - dihydro - 1,2,4 - benzothiadiazine - 1,1 - dioxide; (B3) 5 - chloro - 2,4 - disulphamoyl - aniline, furosemide, dichlorphenamide, chlorthialidone, acetazolamide, chlorazanil; is overcome by coadministering therewith a potassium-sparing amount of a diuretic selected from (A) (3,5 - diamino - 6 - chloropyrazinoyl) guanidine, (3 - amino - 5 - dimethylamino - 6 - chloropyrazinoyl) guanidine, (3,5 - diamino - 6 - chloropyrazinamido) guanidine. Diuretic and/or saluretic pharmaceutical preparations in unit dosage forms comprise one diuretic selected from B1, B2 or B3 and one from A. The preparations may be administered orally in the form of a capsule, tablet, aqueous or alcoholic suspension or solution.
GB423167A 1967-01-27 1967-01-27 Diuretics Expired GB1141422A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB423167A GB1141422A (en) 1967-01-27 1967-01-27 Diuretics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB423167A GB1141422A (en) 1967-01-27 1967-01-27 Diuretics

Publications (1)

Publication Number Publication Date
GB1141422A true GB1141422A (en) 1969-01-29

Family

ID=9773209

Family Applications (1)

Application Number Title Priority Date Filing Date
GB423167A Expired GB1141422A (en) 1967-01-27 1967-01-27 Diuretics

Country Status (1)

Country Link
GB (1) GB1141422A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007259A1 (en) * 1985-06-14 1986-12-18 Massachusetts Eye & Ear Infirmary Increasing aqueous humor outflow
US4757089A (en) * 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
US5306731A (en) * 1985-06-14 1994-04-26 Massachusetts Eye And Ear Infirmary Method and products for treating the eye
US5458883A (en) * 1994-01-12 1995-10-17 Duke University Method of treating disorders of the eye
US5863948A (en) * 1985-06-14 1999-01-26 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007259A1 (en) * 1985-06-14 1986-12-18 Massachusetts Eye & Ear Infirmary Increasing aqueous humor outflow
US4757089A (en) * 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
US5306731A (en) * 1985-06-14 1994-04-26 Massachusetts Eye And Ear Infirmary Method and products for treating the eye
US5863948A (en) * 1985-06-14 1999-01-26 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
US5458883A (en) * 1994-01-12 1995-10-17 Duke University Method of treating disorders of the eye
US6126957A (en) * 1994-01-12 2000-10-03 Duke University Method of treating disorders of the eye
US6534082B1 (en) 1994-01-12 2003-03-18 Duke University Method of treating disorders of the eye

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