GB1139994A - Novel acrylic acid derivatives and process for the preparation thereof - Google Patents
Novel acrylic acid derivatives and process for the preparation thereofInfo
- Publication number
- GB1139994A GB1139994A GB1075667A GB1075667A GB1139994A GB 1139994 A GB1139994 A GB 1139994A GB 1075667 A GB1075667 A GB 1075667A GB 1075667 A GB1075667 A GB 1075667A GB 1139994 A GB1139994 A GB 1139994A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acrylic acid
- formula
- acid addition
- acid derivatives
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,139,994. Acrylic acid derivatives. GEBRUDER GIULINI G.m.b.H. 7 March, 1967 [8 March, 1966], No. 10756/67. Heading C2C. Novel acrylic acid derivatives having the formula wherein R is an alkyl group containing at least 2 carbon atoms; R 1 and R 2 , which may be the same or different, are each a phenyl group or a phenyl group substituted by at least one alkyl or alkoxy group; R 3 and R 4 , which may be the same or different, are each an alkyl group or, together with the adjacent nitrogen atom form a 6-membered heterocyclic group; and n is 2 or 3; and non-toxic acid addition salts thereof are prepared by reaction of an acrylic acid derivative having the formula R 1 R 2 C= CRCOOH or a salt thereof with an amine of the formula Hal.(CH 2 ) n -NR 3 R 4 , wherein Hal is a halogen atom, or an acid addition salt thereof, followed by optional conversion to a non-toxic acid addition salt of the product. Pharmaceutical compositions having antiphlogistic activity comprise at least one acrylic acid derivative of the first formula above or non-toxic acid addition salt thereof together with a pharmaceutical carrier or excipient.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEG46252A DE1292652B (en) | 1966-03-08 | 1966-03-08 | Basically substituted esters of trisubstituted acrylic acids, their hydrochlorides and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1139994A true GB1139994A (en) | 1969-01-15 |
Family
ID=7127975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1075667A Expired GB1139994A (en) | 1966-03-08 | 1967-03-07 | Novel acrylic acid derivatives and process for the preparation thereof |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT271454B (en) |
| BE (1) | BE695052A (en) |
| CH (1) | CH478090A (en) |
| DE (1) | DE1292652B (en) |
| DK (1) | DK114548B (en) |
| ES (1) | ES337592A1 (en) |
| FR (1) | FR1536213A (en) |
| GB (1) | GB1139994A (en) |
| NL (1) | NL6703540A (en) |
| SE (1) | SE315881B (en) |
-
1966
- 1966-03-08 DE DEG46252A patent/DE1292652B/en active Pending
-
1967
- 1967-02-23 AT AT177867A patent/AT271454B/en active
- 1967-03-04 ES ES337592A patent/ES337592A1/en not_active Expired
- 1967-03-06 NL NL6703540A patent/NL6703540A/xx unknown
- 1967-03-06 BE BE695052D patent/BE695052A/xx unknown
- 1967-03-07 DK DK116867A patent/DK114548B/en unknown
- 1967-03-07 CH CH329167A patent/CH478090A/en not_active IP Right Cessation
- 1967-03-07 FR FR69048367A patent/FR1536213A/en not_active Expired
- 1967-03-07 GB GB1075667A patent/GB1139994A/en not_active Expired
- 1967-03-08 SE SE317367A patent/SE315881B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6703540A (en) | 1967-09-11 |
| DK114548B (en) | 1969-07-14 |
| FR1536213A (en) | 1968-08-16 |
| SE315881B (en) | 1969-10-13 |
| AT271454B (en) | 1969-06-10 |
| DE1292652B (en) | 1969-04-17 |
| CH478090A (en) | 1969-09-15 |
| ES337592A1 (en) | 1968-03-01 |
| BE695052A (en) | 1967-08-14 |
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