GB1137508A - Improvements in or relating to the production of substituted 2,8-diazaspiro[4,5]-decan-1,3-diones - Google Patents

Improvements in or relating to the production of substituted 2,8-diazaspiro[4,5]-decan-1,3-diones

Info

Publication number
GB1137508A
GB1137508A GB2427666A GB2427666A GB1137508A GB 1137508 A GB1137508 A GB 1137508A GB 2427666 A GB2427666 A GB 2427666A GB 2427666 A GB2427666 A GB 2427666A GB 1137508 A GB1137508 A GB 1137508A
Authority
GB
United Kingdom
Prior art keywords
general formula
diazaspiro
diones
decan
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2427666A
Inventor
Ernst Jucker
Adolf Lindenmann
Rudolf Sueess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1137508A publication Critical patent/GB1137508A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,137,508. Substituted 2,8 - diazaspiro[4,5]- decan 1,3-diones. SANDOZ Ltd. 31 May, 1966 [9 June, 1965], No. 24276/66. Heading C2C. Substituted 2,8 - diazaspiro[4,5]decan - 1,3- diones of the general formula wherein R is a C 1-6 alkyl, cycloalkyl, aryl or aralkyl radical, and acid addition salts thereof, are prepared by hydrolysing a succinimide of the formula wherein R has the above significance and R<SP>1</SP> is a hydrocarbon radical, with a strong mineral acid at the boil, the resulting acid addition salt is reacted with an alkali to produce the free base when this is required, and when an acid addition salt is desired, salification is effected. Succinimides of the second general formula above are prepared by reacting the corresponding N-methyl compound with a chloroformic ester. Butyrophenones of the general formula wherein R has the above significance, are prepared by reacting compounds of the first general formula above and 4-chloro-1-(4-fluorophenyl)-butan-1-one.
GB2427666A 1965-06-09 1966-05-31 Improvements in or relating to the production of substituted 2,8-diazaspiro[4,5]-decan-1,3-diones Expired GB1137508A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH806665A CH460003A (en) 1965-06-09 1965-06-09 Process for the preparation of heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB1137508A true GB1137508A (en) 1968-12-27

Family

ID=4334600

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2427666A Expired GB1137508A (en) 1965-06-09 1966-05-31 Improvements in or relating to the production of substituted 2,8-diazaspiro[4,5]-decan-1,3-diones

Country Status (5)

Country Link
CH (1) CH460003A (en)
DE (1) DE1620372A1 (en)
DK (1) DK115475B (en)
GB (1) GB1137508A (en)
NL (1) NL6607775A (en)

Also Published As

Publication number Publication date
DK115475B (en) 1969-10-13
DE1620372A1 (en) 1970-03-26
NL6607775A (en) 1966-12-12
CH460003A (en) 1968-07-31

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