GB1125409A - Pharmaceutical compositions containing sulphoxides - Google Patents

Pharmaceutical compositions containing sulphoxides

Info

Publication number
GB1125409A
GB1125409A GB3380266A GB3380266A GB1125409A GB 1125409 A GB1125409 A GB 1125409A GB 3380266 A GB3380266 A GB 3380266A GB 3380266 A GB3380266 A GB 3380266A GB 1125409 A GB1125409 A GB 1125409A
Authority
GB
United Kingdom
Prior art keywords
sulphoxides
compositions
penetrant
aliphatic
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3380266A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1125409A publication Critical patent/GB1125409A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
    • C07D333/48—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom by oxygen atoms

Abstract

1,125,409. Compositions containing sulphoxides. MERCK & CO. Inc. 27 July, 1966 [2 Aug., 1965], No. 33802/66. Headings A5B and A5E. [Also in Division D2] Pharmaceutical and biocidal compositions comprise hydroxy-aliphatic sulphoxides or their acyl esters, of formula: or their cyclic acetals, of formula: wherein each of R and R<SP>1</SP> is an aliphatic or cyclo-aliphatic group, or R and R<SP>1</SP> together are an alkylene group of at least 3 carbons forming a heterocycle with the sulphur atom, R<SP>1</SP> in the cyclic acetals having at least 2 adjacent carbons to which are attached the oxygen atoms; X<SP>1</SP> is hydrogen or an acyl radical, R<SP>2</SP> and R<SP>3</SP> are each alkyl, and n and n' are each 0-2, with n + n' being 1 or 2; together with an inert carrier diluent or coating, which, if other than a solid or an oil, includes one or more sweetening, flavouring, colouring, preserving, suspending or wetting agents; optionally together with other active ingredients. The pharmaceutical compositions may be in forms suitable for oral, parenteral or topical application, and may be tablets, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, syrups or elixirs, skin penetrant ointments, lotions, sprays or creams, and mucosally absorbed forms such as suppositories and nasal compositions. The sulphoxides have tissue penetrant properties and may be included in compositions containing other, non-penetrant active agents, to promote absorption of the latter. Preferred such compositions are anti-perspirant creams, lotions, powders, emulsions or self-propelled aerosols, wherein the further active agent is a metal salt astringent such as zirconium lactate, zinc phenol sulphonate, or an aluminium salt such as the chloride-hydrate, hydroxidedichloride-hydrate, phosphate, sulphonate, or phenolsulphonate. The sulphoxides have anti-inflammatory activity including analgesic and anti-pyretic properties, and they also relieve respiratory congestion; additionally they have muscle relaxant, microbicidal, (including fungi and viruses), and diuretic properties, and have application in the treatment of burns and circulatory deficiencies and to promote the healing of skin grafts. The invention includes a method for treating animals to relieve pain, fever and inflammation, comprising administering the sulphoxide. Biocidal compositions of the active sulphoxides are useful for freeing a non-human locus from micro-organisms, including fungi, bacteria and viruses, and they may be employed as industrial slimicides in re-cycled water, used in air-conditioning units, or the textile or chemical industries.
GB3380266A 1965-08-02 1966-07-27 Pharmaceutical compositions containing sulphoxides Expired GB1125409A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47667665A 1965-08-02 1965-08-02

Publications (1)

Publication Number Publication Date
GB1125409A true GB1125409A (en) 1968-08-28

Family

ID=23892803

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3380266A Expired GB1125409A (en) 1965-08-02 1966-07-27 Pharmaceutical compositions containing sulphoxides

Country Status (5)

Country Link
BE (1) BE684960A (en)
FR (2) FR5698M (en)
GB (1) GB1125409A (en)
IL (1) IL26210A (en)
NL (1) NL6610878A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888164A (en) * 1985-12-27 1989-12-19 L'oreal Cosmetic composition for the treatment of oily skin and hair based on di(beta-hydroxyethyl) sulfoxide and the use thereof
EP1693052A1 (en) * 2001-10-03 2006-08-23 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
US9271931B2 (en) 2001-10-03 2016-03-01 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
US10058507B2 (en) 2001-10-03 2018-08-28 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984480A (en) * 1970-05-12 1976-10-05 L'oreal Polyhydroxyl monosulfoxide surfactant

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888164A (en) * 1985-12-27 1989-12-19 L'oreal Cosmetic composition for the treatment of oily skin and hair based on di(beta-hydroxyethyl) sulfoxide and the use thereof
EP1693052A1 (en) * 2001-10-03 2006-08-23 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
US9271931B2 (en) 2001-10-03 2016-03-01 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
US10058507B2 (en) 2001-10-03 2018-08-28 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
US10722464B2 (en) 2001-10-03 2020-07-28 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations

Also Published As

Publication number Publication date
FR1505490A (en) 1967-12-15
IL26210A (en) 1970-12-24
FR5698M (en) 1968-02-19
BE684960A (en) 1967-02-02
NL6610878A (en) 1967-02-03

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