GB1122863A - Steroid 21-phosphates - Google Patents

Steroid 21-phosphates

Info

Publication number
GB1122863A
GB1122863A GB1846366A GB1846366A GB1122863A GB 1122863 A GB1122863 A GB 1122863A GB 1846366 A GB1846366 A GB 1846366A GB 1846366 A GB1846366 A GB 1846366A GB 1122863 A GB1122863 A GB 1122863A
Authority
GB
United Kingdom
Prior art keywords
phosphates
ols
steroid
hydrolyl
dichlorophosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1846366A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1122863A publication Critical patent/GB1122863A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Abstract

Phosphates of pregnan-21-ols are prepared from the free ols and pyrophosphoryl chloride, with aqueous hydrolysis of the first-formed 21-dichlorophosphate. The starting steroid may not have any ring-unattached unprotected hydroxyl groups except that an 11-hydroxy group may be present when there is a 9-halo or 9-alkyl substituent. The products may be converted to their alkali metal salts, and protected hydrolyl groups may be released.
GB1846366A 1965-05-04 1966-04-27 Steroid 21-phosphates Expired GB1122863A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45317365A 1965-05-04 1965-05-04

Publications (1)

Publication Number Publication Date
GB1122863A true GB1122863A (en) 1968-08-07

Family

ID=23799466

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1846366A Expired GB1122863A (en) 1965-05-04 1966-04-27 Steroid 21-phosphates

Country Status (4)

Country Link
BR (1) BR6678983D0 (en)
CH (1) CH469742A (en)
DE (1) DE1593011A1 (en)
GB (1) GB1122863A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008224A (en) 1973-11-19 1977-02-15 Ciba-Geigy Corporation Process for the manufacture of cyano-substituted stilbene compounds
WO1991001991A1 (en) * 1987-12-04 1991-02-21 Sri International New topically active steroidal anti-inflammatory agents
WO2011029547A3 (en) * 2009-09-11 2011-08-18 Chiesi Farmaceutici S.P.A. Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008224A (en) 1973-11-19 1977-02-15 Ciba-Geigy Corporation Process for the manufacture of cyano-substituted stilbene compounds
WO1991001991A1 (en) * 1987-12-04 1991-02-21 Sri International New topically active steroidal anti-inflammatory agents
WO2011029547A3 (en) * 2009-09-11 2011-08-18 Chiesi Farmaceutici S.P.A. Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents
US8637662B2 (en) 2009-09-11 2014-01-28 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
AU2010294598B2 (en) * 2009-09-11 2016-09-01 Chiesi Farmaceutici S.P.A. Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents
EA025191B1 (en) * 2009-09-11 2016-11-30 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Pregnane derivatives condensed by 16,17 position with n-substituted izoxalidine ring as anti-inflammatory agents

Also Published As

Publication number Publication date
CH469742A (en) 1969-03-15
BR6678983D0 (en) 1973-09-18
DE1593011A1 (en) 1970-07-30

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